PDB entry 6xxn

View 6xxn on RCSB PDB site
Description: Crystal structure of NB7, a nanobody targeting prostate specific membrane antigen
Class: antitumor protein
Keywords: Nanobody, prostate specific membrane, antigen, antibody drug conjugate, cancer imaging, anti-cancer drugs, ANTITUMOR PROTEIN
Deposited on 2020-01-28, released 2020-06-10
The last revision prior to the SCOPe 2.07 freeze date was dated 2020-06-10, with a file datestamp of 2020-06-05.
Experiment type: XRAY
Resolution: 2.65 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: NB_7_a,b,c,f
    Species: Camelus dromedarius [TaxId:9838]
    Database cross-references and differences (RAF-indexed):
    • PDB 6XXN
    Domains in SCOPe 2.07: d6xxna1, d6xxna2
  • Chain 'B':
    Compound: NB_7_a,b,c,f
    Species: Camelus dromedarius [TaxId:9838]
    Database cross-references and differences (RAF-indexed):
    • PDB 6XXN
    Domains in SCOPe 2.07: d6xxnb1, d6xxnb2
  • Chain 'C':
    Compound: NB_7_a,b,c,f
    Species: Camelus dromedarius [TaxId:9838]
    Database cross-references and differences (RAF-indexed):
    • PDB 6XXN
    Domains in SCOPe 2.07: d6xxnc1, d6xxnc2
  • Chain 'D':
    Compound: NB_7_a,b,c,f
    Species: Camelus dromedarius [TaxId:9838]
    Database cross-references and differences (RAF-indexed):
    • PDB 6XXN
    Domains in SCOPe 2.07: d6xxnd1, d6xxnd2
  • Chain 'E':
    Compound: NB_7_a,b,c,f
    Species: Camelus dromedarius [TaxId:9838]
    Database cross-references and differences (RAF-indexed):
    • PDB 6XXN
    Domains in SCOPe 2.07: d6xxne1, d6xxne2
  • Chain 'F':
    Compound: NB_7_a,b,c,f
    Species: Camelus dromedarius [TaxId:9838]
    Database cross-references and differences (RAF-indexed):
    • PDB 6XXN
    Domains in SCOPe 2.07: d6xxnf1, d6xxnf2
  • Chain 'G':
    Compound: NB_7_g
    Species: Camelus dromedarius [TaxId:9838]
    Database cross-references and differences (RAF-indexed):
    • PDB 6XXN
    Domains in SCOPe 2.07: d6xxng1, d6xxng2
  • Chain 'H':
    Compound: NB_7_h
    Species: Camelus dromedarius [TaxId:9838]
    Database cross-references and differences (RAF-indexed):
    • PDB 6XXN
    Domains in SCOPe 2.07: d6xxnh1, d6xxnh2
  • Heterogens: SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6xxnA (A:)
qvqlqesgggsvqaggslrlsctapgytdsnyymswfrqapgkerewvagvntgrgstsy
adsvkgrftisqdnakntmflqmnslkpedtaiyycavaachfcdslpktqdeyilwgqg
tqvtvssaaaypydvpdygshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6xxnA (A:)
qlqesgggsvqaggslrlsctapgytdsnyymswfrqapgkerewvagvntgrgstsyad
svkgrftisqdnakntmflqmnslkpedtaiyycavaachfcdslpktqdeyilwgqgtq
vtvss

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6xxnB (B:)
qvqlqesgggsvqaggslrlsctapgytdsnyymswfrqapgkerewvagvntgrgstsy
adsvkgrftisqdnakntmflqmnslkpedtaiyycavaachfcdslpktqdeyilwgqg
tqvtvssaaaypydvpdygshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6xxnB (B:)
qlqesgggsvqaggslrlsctapgytdsnyymswfrqapgkerewvagvntgrgstsyad
svkgrftisqdnakntmflqmnslkpedtaiyycavaachfcdslpktqdeyilwgqgtq
vtvss

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6xxnC (C:)
qvqlqesgggsvqaggslrlsctapgytdsnyymswfrqapgkerewvagvntgrgstsy
adsvkgrftisqdnakntmflqmnslkpedtaiyycavaachfcdslpktqdeyilwgqg
tqvtvssaaaypydvpdygshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6xxnC (C:)
qlqesgggsvqaggslrlsctapgytdsnyymswfrqapgkerewvagvntgrgstsyad
svkgrftisqdnakntmflqmnslkpedtaiyycavaachfcdslpktqdeyilwgqgtq
vtvss

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6xxnD (D:)
qvqlqesgggsvqaggslrlsctapgytdsnyymswfrqapgkerewvagvntgrgstsy
adsvkgrftisqdnakntmflqmnslkpedtaiyycavaachfcdslpktqdeyilwgqg
tqvtvssaaaypydvpdygshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6xxnD (D:)
qlqesgggsvqaggslrlsctapgytdsnyymswfrqapgkerewvagvntgrgstsyad
svkgrftisqdnakntmflqmnslkpedtaiyycavaachfcdslpktqdeyilwgqgtq
vtvs

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6xxnE (E:)
qvqlqesgggsvqaggslrlsctapgytdsnyymswfrqapgkerewvagvntgrgstsy
adsvkgrftisqdnakntmflqmnslkpedtaiyycavaachfcdslpktqdeyilwgqg
tqvtvssaaaypydvpdygshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6xxnE (E:)
qlqesgggsvqaggslrlsctapgytdsnyymswfrqapgkerewvagvntgrgstsyad
svkgrftisqdnakntmflqmnslkpedtaiyycavaachfcdslpktqdeyilwgqgtq
vtvs

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6xxnF (F:)
qvqlqesgggsvqaggslrlsctapgytdsnyymswfrqapgkerewvagvntgrgstsy
adsvkgrftisqdnakntmflqmnslkpedtaiyycavaachfcdslpktqdeyilwgqg
tqvtvssaaaypydvpdygshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6xxnF (F:)
qlqesgggsvqaggslrlsctapgytdsnyymswfrqapgkerewvagvntgrgstsyad
svkgrftisqdnakntmflqmnslkpedtaiyycavaachfcdslpktqdeyilwgqgtq
vtvss

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >6xxnG (G:)
qvqlqesgggsvtaggslrlsctapgytdsnyymswfrqapgkerewvagvntgrgstsy
adsvkgrftisqdnakntmflqmnslkpedtaiyycavaachfcdslpktqdeyilwgqg
tqvtvssaaaypydvpdygshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6xxnG (G:)
qlqesgggsvtaggslrlsctapgytdsnyymswfrqapgkerewvagvntgrgstsyad
svkgrftisqdnakntmflqmnslkpedtaiyycavaachfcdslpktqdeyilwgqgtq
vtvs

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >6xxnH (H:)
qvqlqesgggsvqaggslrlsctapgytdsnyymswfrqapgkerewvagvntgrgstsy
adsvkgrftisqdnakntmflqmnslkpedtaqyycavaachfcdslpktqdeyilwgqg
tqvtvssaaaypydvpdygshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6xxnH (H:)
qlqesgggsvqaggslrlsctapgytdsnyymswfrqapgkerewvagvntgrgstsyad
svkgrftisqdnakntmflqmnslkpedtaqyycavaachfcdslpktqdeyilwgqgtq
vtvs