PDB entry 6xfv

View 6xfv on RCSB PDB site
Description: crystal structure of rar-related orphan receptor c in complex with a novel inverse agonist
Class: TRANSCRIPTION/Agonist
Keywords: RORGT, NUCLEAR HORMONE RECEPTOR, LIGAND-BINDING DOMAIN, INVERSE AGONIST, TRANSCRIPTION-Agonist complex
Deposited on 2020-06-16, released 2020-08-12
The last revision prior to the SCOPe 2.07 freeze date was dated 2020-08-12, with a file datestamp of 2020-08-07.
Experiment type: XRAY
Resolution: 2.15 Å
R-factor: N/A
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Nuclear receptor ROR-gamma
    Species: Homo sapiens [TaxId:9606]
    Gene: RORC, NR1F3, RORG, RZRG
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6xfva_
  • Chain 'B':
    Compound: Nuclear receptor ROR-gamma
    Species: Homo sapiens [TaxId:9606]
    Gene: RORC, NR1F3, RORG, RZRG
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6xfvb_
  • Heterogens: V27, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6xfvA (A:)
mgsshhhhhhssglvprgshmaslteiehlvqsvcksyretcqlrledllrqrsnifsre
evtgyqrksmwemwercahhlteaiqyvvefakrlsgfmelcqndqivllkagamevvlv
rmcraynadnrtvffegkyggmelfralgcselissifdfshslsalhfsedeialytal
vlinahrpglqekrkveqlqynlelafhhhlckthrqsilaklppkgklrslcsqhverl
qifqhlhpivvqaafpplykelfst

    Sequence, based on observed residues (ATOM records): (download) 
    >6xfvA (A:)
aslteiehlvqsvcksyretcqlrledllrqrsnifsreevtgyqrksmwemwercahhl
teaiqyvvefakrlsgfmelcqndqivllkagamevvlvrmcraynadnrtvffegkygg
melfralgcselissifdfshslsalhfsedeialytalvlinahrpglqekrkveqlqy
nlelafhhhlckthrqsilaklppkgklrslcsqhverlqi

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6xfvB (B:)
mgsshhhhhhssglvprgshmaslteiehlvqsvcksyretcqlrledllrqrsnifsre
evtgyqrksmwemwercahhlteaiqyvvefakrlsgfmelcqndqivllkagamevvlv
rmcraynadnrtvffegkyggmelfralgcselissifdfshslsalhfsedeialytal
vlinahrpglqekrkveqlqynlelafhhhlckthrqsilaklppkgklrslcsqhverl
qifqhlhpivvqaafpplykelfst

    Sequence, based on observed residues (ATOM records): (download) 
    >6xfvB (B:)
aslteiehlvqsvcksyretcqlrledllrqrsnifsreevtgyqrksmwemwercahhl
teaiqyvvefakrlsgfmelcqndqivllkagamevvlvrmcraynadnrtvffegkygg
melfralgcselissifdfshslsalhfsedeialytalvlinahrpglqekrkveqlqy
nlelafhhhlckthrqsilaklppkgklrslcsqhverlqi