PDB entry 6w7s

View 6w7s on RCSB PDB site
Description: Ketoreductase from module 1 of the 6-deoxyerythronolide B synthase (KR1) in complex with antibody fragment (Fab) 2G10
Class: oxidoreductase/immune system
Keywords: ketoreductase, antibody fragment, OXIDOREDUCTASE-IMMUNE SYSTEM complex
Deposited on 2020-03-19, released 2020-09-09
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-09-16, with a file datestamp of 2020-09-11.
Experiment type: XRAY
Resolution: 2.25 Å
R-factor: N/A
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: EryAI
    Species: Saccharopolyspora erythraea [TaxId:1836]
    Gene: eryAI
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6w7sa1, d6w7sa2
  • Chain 'H':
    Compound: 2G10 (Fab heavy chain)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6W7S
  • Chain 'L':
    Compound: 2G10 (Fab light chain)
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6W7S
    Domains in SCOPe 2.08: d6w7sl1, d6w7sl2
  • Heterogens: MES, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6w7sA (A:)
gshmdevsalryriewrptgageparldgtwlvakyagtadetstaarealesagarvre
lvvdarcgrdelaerlrsvgevagvlsllavdeaepeeaplalasladtlslvqamvsae
lgcplwtvtesavatgpfervrnaahgalwgvgrvialenpavwgglvdvpagsvaelar
hlaavvsggagedqlalradgvygrrwvraaapatddewkptgtvlvtggtggvggqiar
wlarrgaphlllvsrsgpdadgagelvaelealgarttvaacdvtdresvrellggigdd
vplsavfhaaatlddgtvdtltgerierasrakvlgarnlheltreldltafvlfssfas
afgapglggyapgnayldglaqqrrsdglpatavawgtwagsgmaegpvadrfrrhgvie
mppetacralqnaldraevcpividvrwdrfllaytaqrptrlfdeiddarraapqaaae
prvga

    Sequence, based on observed residues (ATOM records): (download) 
    >6w7sA (A:)
devsalryriewrptgageparldgtwlvakyagtadetstaarealesagarvrelvvd
arcgrdelaerlrsvgevagvlsllavdeaepeeaplalasladtlslvqamvsaelgcp
lwtvtesavatgpfervrnaahgalwgvgrvialenpavwgglvdvpagsvaelarhlaa
vvsggagedqlalradgvygrrwvraaddewkptgtvlvtggtggvggqiarwlarrgap
hlllvsrsgpdadgagelvaelealgarttvaacdvtdresvrellggigddvplsavfh
aaatlddgtvdtltgerierasrakvlgarnlheltreldltafvlfssfasafgapglg
gyapgnayldglaqqrrsdglpatavawgtwagsgmaegpvadrfrrhgviemppetacr
alqnaldraevcpividvrwdrfllaytaqrptrlfdeiddar

  • Chain 'H':
    No sequence available.

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >6w7sL (L:)
lfaiplvvpfyshsaqavltqpsslsaspgasasltctlrsginvgtyriywyqqkpgsp
pqyllryksdsdkqqgsgvpsrfsgskdasanagillisglqsedeadyycmtwhssayv
fgtgtkvtvlgqpkanptvtlfppsseelqankatlvclisdfypgavtvawkadgspvk
agvettkpskqsnnkyaassylsltpeqwkshrsyscqvthegstvektvaptecs

    Sequence, based on observed residues (ATOM records): (download) 
    >6w7sL (L:)
vltqpsslsaspgasasltctlrsginvgtyriywyqqkpgsppqyllryksdsdkqqgs
gvpsrfsgskdasanagillisglqsedeadyycmtwhssayvfgtgtkvtvlgqpkanp
tvtlfppsseelqankatlvclisdfypgavtvawkadgspvkagvettkpskqsnnkya
assylsltpeqwkshrsyscqvthegstvektvapt