PDB entry 6w5l

View 6w5l on RCSB PDB site
Description: 2.1 A resolution structure of Norovirus 3CL protease in complex with inhibitor 7g
Class: HYDROLASE/HYDROLASE Inhibitor
Keywords: PROTEASE, Norovirus 3CL protease, Inhhibitors, HYDROLASE, HYDROLASE-HYDROLASE Inhibitor complex
Deposited on 2020-03-13, released 2020-09-30
The last revision prior to the SCOPe 2.07 freeze date was dated 2020-09-30, with a file datestamp of 2020-09-25.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 3C-like protease
    Species: Norwalk virus (strain GI/Human/United States/Norwalk/1968) [TaxId:524364]
    Gene: ORF1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q83883 (7-End)
      • expression tag (6)
    Domains in SCOPe 2.07: d6w5la1, d6w5la2
  • Chain 'B':
    Compound: 3C-like protease
    Species: Norwalk virus (strain GI/Human/United States/Norwalk/1968) [TaxId:524364]
    Gene: ORF1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q83883 (7-End)
      • expression tag (5-6)
    Domains in SCOPe 2.07: d6w5lb1, d6w5lb2
  • Chain 'C':
    Compound: 3C-like protease
    Species: Norwalk virus (strain GI/Human/United States/Norwalk/1968) [TaxId:524364]
    Gene: ORF1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q83883 (7-End)
      • expression tag (6)
    Domains in SCOPe 2.07: d6w5lc1, d6w5lc2
  • Chain 'D':
    Compound: 3C-like protease
    Species: Norwalk virus (strain GI/Human/United States/Norwalk/1968) [TaxId:524364]
    Gene: ORF1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q83883 (7-End)
      • expression tag (5-6)
    Domains in SCOPe 2.07: d6w5ld1, d6w5ld2
  • Heterogens: T0D, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6w5lA (A:)
hhhhhhhapptlwsrvtkfgsgwgfwvsptvfittthvvptgvkeffgeplssiaihqag
eftqfrfskkmrpdltgmvleegcpegtvcsvlikrdsgellplavrmgaiasmriqgrl
vhgqsgmlltganakgmdlgtipgdcgapyvhkrgndwvvcgvhaaatksgntvvcavqa
gegetale

    Sequence, based on observed residues (ATOM records): (download) 
    >6w5lA (A:)
happtlwsrvtkfgsgwgfwvsptvfittthvvptgvkeffgeplssiaihqageftqfr
fskkmrpdltgmvleegcpegtvcsvlikrdsgellplavrmgaiasmriqgrlvhgqsg
mlllgtipgdcgapyvhkrgndwvvcgvhaaatksgntvvcavqa

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6w5lB (B:)
hhhhhhhapptlwsrvtkfgsgwgfwvsptvfittthvvptgvkeffgeplssiaihqag
eftqfrfskkmrpdltgmvleegcpegtvcsvlikrdsgellplavrmgaiasmriqgrl
vhgqsgmlltganakgmdlgtipgdcgapyvhkrgndwvvcgvhaaatksgntvvcavqa
gegetale

    Sequence, based on observed residues (ATOM records): (download) 
    >6w5lB (B:)
hhapptlwsrvtkfgsgwgfwvsptvfittthvvptgvkeffgeplssiaihqageftqf
rfskkmrpdltgmvleegcpegtvcsvlikrdsgellplavrmgaiasmriqgrlvhgqs
gmlllgtipgdcgapyvhkrgndwvvcgvhaaatksgntvvcavqa

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6w5lC (C:)
hhhhhhhapptlwsrvtkfgsgwgfwvsptvfittthvvptgvkeffgeplssiaihqag
eftqfrfskkmrpdltgmvleegcpegtvcsvlikrdsgellplavrmgaiasmriqgrl
vhgqsgmlltganakgmdlgtipgdcgapyvhkrgndwvvcgvhaaatksgntvvcavqa
gegetale

    Sequence, based on observed residues (ATOM records): (download) 
    >6w5lC (C:)
happtlwsrvtkfgsgwgfwvsptvfittthvvptgvkeffgeplssiaihqageftqfr
fskkmrpdltgmvleegcpegtvcsvlikrdsgellplavrmgaiasmriqgrlvhgqsg
mlllgtipgdcgapyvhkrgndwvvcgvhaaatntvvcavqa

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6w5lD (D:)
hhhhhhhapptlwsrvtkfgsgwgfwvsptvfittthvvptgvkeffgeplssiaihqag
eftqfrfskkmrpdltgmvleegcpegtvcsvlikrdsgellplavrmgaiasmriqgrl
vhgqsgmlltganakgmdlgtipgdcgapyvhkrgndwvvcgvhaaatksgntvvcavqa
gegetale

    Sequence, based on observed residues (ATOM records): (download) 
    >6w5lD (D:)
hhapptlwsrvtkfgsgwgfwvsptvfittthvvptgvkeffgeplssiaihqageftqf
rfskkmrpdltgmvleegcpegtvcsvlikrdsgellplavrmgaiasmriqgrlvhgqs
gmlldlgtipgdcgapyvhkrgndwvvcgvhaaatksgntvvcavqa