PDB entry 6w5h

View 6w5h on RCSB PDB site
Description: 1.85 A resolution structure of Norovirus 3CL protease in complex with inhibitor 5d
Class: HYDROLASE/HYDROLASE Inhibitor
Keywords: PROTEASE, Norovirus 3CL protease, Inhhibitors, HYDROLASE, HYDROLASE-HYDROLASE Inhibitor complex
Deposited on 2020-03-13, released 2020-09-30
The last revision prior to the SCOPe 2.07 freeze date was dated 2020-10-14, with a file datestamp of 2020-10-09.
Experiment type: XRAY
Resolution: 1.85 Å
R-factor: N/A
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 3C-like protease
    Species: Norwalk virus (strain GI/Human/United States/Norwalk/1968) [TaxId:524364]
    Gene: ORF1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q83883 (6-End)
      • expression tag (2-5)
    Domains in SCOPe 2.07: d6w5ha1, d6w5ha2
  • Chain 'B':
    Compound: 3C-like protease
    Species: Norwalk virus (strain GI/Human/United States/Norwalk/1968) [TaxId:524364]
    Gene: ORF1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q83883 (6-End)
      • expression tag (3-5)
    Domains in SCOPe 2.07: d6w5hb1, d6w5hb2
  • Chain 'C':
    Compound: 3C-like protease
    Species: Norwalk virus (strain GI/Human/United States/Norwalk/1968) [TaxId:524364]
    Gene: ORF1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q83883 (6-End)
      • expression tag (5)
    Domains in SCOPe 2.07: d6w5hc1, d6w5hc2
  • Chain 'D':
    Compound: 3C-like protease
    Species: Norwalk virus (strain GI/Human/United States/Norwalk/1968) [TaxId:524364]
    Gene: ORF1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q83883 (6-End)
      • expression tag (5)
    Domains in SCOPe 2.07: d6w5hd1, d6w5hd2
  • Heterogens: TKP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6w5hA (A:)
hhhhhhapptlwsrvtkfgsgwgfwvsptvfittthvvptgvkeffgeplssiaihqage
ftqfrfskkmrpdltgmvleegcpegtvcsvlikrdsgellplavrmgaiasmriqgrlv
hgqsgmlltganakgmdlgtipgdcgapyvhkrgndwvvcgvhaaatksgntvvcavqag
egetale

    Sequence, based on observed residues (ATOM records): (download) 
    >6w5hA (A:)
hhhhapptlwsrvtkfgsgwgfwvsptvfittthvvptgvkeffgeplssiaihqageft
qfrfskkmrpdltgmvleegcpegtvcsvlikrdsgellplavrmgaiasmriqgrlvhg
qsgmlllgtipgdcgapyvhkrgndwvvcgvhaaatksgntvvcavqa

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6w5hB (B:)
hhhhhhapptlwsrvtkfgsgwgfwvsptvfittthvvptgvkeffgeplssiaihqage
ftqfrfskkmrpdltgmvleegcpegtvcsvlikrdsgellplavrmgaiasmriqgrlv
hgqsgmlltganakgmdlgtipgdcgapyvhkrgndwvvcgvhaaatksgntvvcavqag
egetale

    Sequence, based on observed residues (ATOM records): (download) 
    >6w5hB (B:)
hhhapptlwsrvtkfgsgwgfwvsptvfittthvvptgvkeffgeplssiaihqageftq
frfskkmrpdltgmvleegcpegtvcsvlikrdsgellplavrmgaiasmriqgrlvhgq
sgmlllgtipgdcgapyvhkrgndwvvcgvhaaatksgntvvcavqa

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6w5hC (C:)
hhhhhhapptlwsrvtkfgsgwgfwvsptvfittthvvptgvkeffgeplssiaihqage
ftqfrfskkmrpdltgmvleegcpegtvcsvlikrdsgellplavrmgaiasmriqgrlv
hgqsgmlltganakgmdlgtipgdcgapyvhkrgndwvvcgvhaaatksgntvvcavqag
egetale

    Sequence, based on observed residues (ATOM records): (download) 
    >6w5hC (C:)
happtlwsrvtkfgsgwgfwvsptvfittthvvpvkeffgeplssiaihqageftqfrfs
kkmrpdltgmvleegcpegtvcsvlikrdsgellplavrmgaiasmriqgrlvhgqsgml
llgtipgdcgapyvhkrgndwvvcgvhaaatksgntvvcavqa

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6w5hD (D:)
hhhhhhapptlwsrvtkfgsgwgfwvsptvfittthvvptgvkeffgeplssiaihqage
ftqfrfskkmrpdltgmvleegcpegtvcsvlikrdsgellplavrmgaiasmriqgrlv
hgqsgmlltganakgmdlgtipgdcgapyvhkrgndwvvcgvhaaatksgntvvcavqag
egetale

    Sequence, based on observed residues (ATOM records): (download) 
    >6w5hD (D:)
happtlwsrvtkfgsgwgfwvsptvfittthvvptgvkeffgeplssiaihqageftqfr
fskkmrpdltgmvleegcpegtvcsvlikrdsgellplavrmgaiasmriqgrlvhgqsg
mlllgtipgdcgapyvhkrgndwvvcgvhaaatksgntvvcavqa