PDB entry 6v2v

View 6v2v on RCSB PDB site
Description: Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP and PD0325901
Class: transferase
Keywords: braf, mek1, transferase
Deposited on 2019-11-25, released 2020-12-02
Made obsolete by 7m0x on 2021-04-21

The last revision prior to the SCOPe 2.07 freeze date was dated 2020-12-02, with a file datestamp of 2020-11-27.
Experiment type: XRAY
Resolution: 2.47 Å
R-factor: N/A
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine/threonine-protein kinase B-raf
    Species: Homo sapiens [TaxId:9606]
    Gene: BRAF, BRAF1, RAFB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6v2va_
  • Chain 'B':
    Compound: Dual specificity mitogen-activated protein kinase kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: MAP2K1, MEK1, PRKMK1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q02750
      • engineered mutation (221)
      • engineered mutation (225)
    Domains in SCOPe 2.07: d6v2vb_
  • Heterogens: 4BM, ANP, MG, CL, SO4, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6v2vA (A:)
gggrdssddweipdgqitvgqrigsgsfgtvykgkwhgdvavkmlnvtaptpqqlqafkn
evgvlrktrhvnillfmgystkpqlaivtqwcegsslyhhlhiietkfemiklidiarqt
aqgmdylhaksiihrdlksnniflhedltvkigdfglatvksrwsgshqfeqlsgsilwm
apevirmqdknpysfqsdvyafgivlyelmtgqlpysninnrdqiifmvgrgylspdlsk
vrsncpkamkrlmaeclkkkrderplfpqilasiellarslpk

    Sequence, based on observed residues (ATOM records): (download) 
    >6v2vA (A:)
sddweipdgqitvgqrigsgsfgtvykgkwhgdvavkmlnvtaptpqqlqafknevgvlr
ktrhvnillfmgystkpqlaivtqwcegsslyhhlhiietkfemiklidiarqtaqgmdy
lhaksiihrdlksnniflhedltvkigdfglatvksrwsgshqfeqlsgsilwmapevir
mqdknpysfqsdvyafgivlyelmtgqlpysninnrdqiifmvgrgylspdlskvrsncp
kamkrlmaeclkkkrderplfpqilasiellarslp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6v2vB (B:)
gggrmpkkkptpiqlnpapdgsavngtssaetnlealqkkleeleldeqqrkrleafltq
kqkvgelkdddfekiselgagnggvvfkvshkpsglvmarklihleikpairnqiirelq
vlhecnspyivgfygafysdgeisicmehmdggsldqvlkkagripeqilgkvsiavikg
ltylrekhkimhrdvkpsnilvnsrgeiklcdfgvsgqlidamanafvgtrsymsperlq
gthysvqsdiwsmglslvemavgrypipppdakelelmfgcqvegdaaetpprprtpgrp
lssygmdsrppmaifelldyivnepppklpsgvfslefqdfvnkcliknpaeradlkqlm
vhafikrsdaeevdfagwlcstiglnqpstpthaagv

    Sequence, based on observed residues (ATOM records): (download) 
    >6v2vB (B:)
eeleldeqqrkrleafltqkqkvgelkdddfekiselgagnggvvfkvshkpsglvmark
lihleikpairnqiirelqvlhecnspyivgfygafysdgeisicmehmdggsldqvlkk
agripeqilgkvsiavikgltylrekhkimhrdvkpsnilvnsrgeiklcdfgvsgqlid
amanafvgtrsymsperlqgthysvqsdiwsmglslvemavgrypipppdakelelmpma
ifelldyivnepppklpsgvfslefqdfvnkcliknpaeradlkqlmvhafikrsdaeev
dfagwlcstiglnq