PDB entry 6t9t

View 6t9t on RCSB PDB site
Description: Matriptase in complex with the synthetic inhibitor (S)-3-(3-(4-(3-(tert-butyl)ureido)piperidin-1-yl)-2-((3'-fluoro-4'-(hydroxymethyl)-[1,1'-biphenyl])-3-sulfonamido)-3-oxopropyl)benzimidamide (MI-1904)
Class: hydrolase
Keywords: Matriptase, Complex, Ligand-binding, HYDROLASE
Deposited on 2019-10-28, released 2020-11-18
The last revision prior to the SCOPe 2.07 freeze date was dated 2020-11-18, with a file datestamp of 2020-11-13.
Experiment type: XRAY
Resolution: 1.69 Å
R-factor: N/A
AEROSPACI score: 0.5 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Suppressor of tumorigenicity 14 protein
    Species: Homo sapiens [TaxId:9606]
    Gene: ST14, PRSS14, SNC19, TADG15
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9Y5Y6 (0-240)
      • engineered mutation (116)
    Domains in SCOPe 2.07: d6t9ta_
  • Heterogens: MXH, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6t9tA (A:)
vvggtdadegewpwqvslhalgqghicgaslispnwlvsaahcyiddrgfrysdptqwta
flglhdqsqrsapgvqerrlkriishpffndftfdydiallelekpaeyssmvrpislpd
ashvfpagkaiwvtgwghtqyggtgalilqkgeirvinqttcenllpqqitprmmcvgfl
sggvdscqgdsggplssveadgrifqagvvswgdgcaqrnkpgvytrlplfrdwikentg
v

    Sequence, based on observed residues (ATOM records): (download) 
    >6t9tA (A:)
vvggtdadegewpwqvslhalgqghicgaslispnwlvsaahcyiddrgfrysdptqwta
flglhdqsqrsapgvqerrlkriishpffndftfdydiallelekpaeyssmvrpislpd
ashvfpagkaiwvtgwghtqyggtgalilqkgeirvinqttcenllpqqitprmmcvgfl
sggvdscqgdsggplssvedgrifqagvvswgdgcaqrnkpgvytrlplfrdwikentgv