PDB entry 6smr

View 6smr on RCSB PDB site
Description: A. thaliana serine hydroxymethyltransferase isoform 4 (AtSHMT4) in complex with methotrexate
Class: transferase
Keywords: SHMT, antifolate, TRANSFERASE
Deposited on 2019-08-22, released 2020-01-08
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-01-08, with a file datestamp of 2020-01-03.
Experiment type: XRAY
Resolution: 2.12 Å
R-factor: N/A
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Serine hydroxymethyltransferase 4
    Species: Arabidopsis thaliana [TaxId:3702]
    Gene: SHM4, SHMT4, At4g13930, dl3005c, FCAALL.160
    Database cross-references and differences (RAF-indexed):
    • Uniprot O23254 (3-End)
      • expression tag (0-2)
    Domains in SCOPe 2.08: d6smra1, d6smra2
  • Chain 'B':
    Compound: Serine hydroxymethyltransferase 4
    Species: Arabidopsis thaliana [TaxId:3702]
    Gene: SHM4, SHMT4, At4g13930, dl3005c, FCAALL.160
    Database cross-references and differences (RAF-indexed):
    • Uniprot O23254 (3-473)
      • expression tag (2)
    Domains in SCOPe 2.08: d6smrb1, d6smrb2
  • Chain 'C':
    Compound: Serine hydroxymethyltransferase 4
    Species: Arabidopsis thaliana [TaxId:3702]
    Gene: SHM4, SHMT4, At4g13930, dl3005c, FCAALL.160
    Database cross-references and differences (RAF-indexed):
    • Uniprot O23254 (3-End)
      • expression tag (2)
    Domains in SCOPe 2.08: d6smrc1, d6smrc2
  • Chain 'D':
    Compound: Serine hydroxymethyltransferase 4
    Species: Arabidopsis thaliana [TaxId:3702]
    Gene: SHM4, SHMT4, At4g13930, dl3005c, FCAALL.160
    Database cross-references and differences (RAF-indexed):
    • Uniprot O23254 (3-End)
      • expression tag (2)
    Domains in SCOPe 2.08: d6smrd1, d6smrd2
  • Heterogens: MTX, PLS, EDO, TRS, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6smrA (A:)
snamepvsswgntslvsvdpeihdliekekrrqcrgieliasenftsfaviealgsaltn
kysegipgnryyggnefideienlcrsraleafhcdpaawgvnvqpysgspanfaaytal
lqphdrimgldlpsgghlthgyytsggkkisatsiyfeslpykvnfttgyidydkleeka
ldfrpkllicggsayprdwdyarfraiadkvgalllcdmahisglvaaqeaanpfeycdv
vtttthkslrgpragmifyrkgpkppkkgqpegavydfedkinfavfpalqggphnhqig
alavalkqantpgfkvyakqvkanavalgnylmskgyqivtngtenhlvlwdlrplgltg
nkveklcdlcsitlnknavfgdssalapggvrigapamtsrglvekdfeqigeflsravt
ltldiqktygkllkdfnkglvnnkdldqlkadvekfsasyempgflmsemkykd

    Sequence, based on observed residues (ATOM records): (download) 
    >6smrA (A:)
snamepvsswgntslvsvdpeihdliekekrrqcrgieliasenftsfaviealgsaltn
kysegipgnryyggnefideienlcrsraleafhcdpaawgvnvqpysgspanfaaytal
lqphdrimgldlpsgghlthgyytsggkkisatsiyfeslpykvnfttgyidydkleeka
ldfrpkllicggsayprdwdyarfraiadkvgalllcdmahisglvaaqeaanpfeycdv
vtttthkslrgpragmifyrkgpkppkkgqpegavydfedkinfavfpalqggphnhqig
alavalkqantpgfkvyakqvkanavalgnylmskgyqivtngtenhlvlwdlrplgltg
nkveklcdlcsitlnknavfgdssalapggvrigapamtsrglvekdfeqigeflsravt
ltldiqktygkllkdfnkglvnnkdldqlkadvekfsasyempgflmsemkyk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6smrB (B:)
snamepvsswgntslvsvdpeihdliekekrrqcrgieliasenftsfaviealgsaltn
kysegipgnryyggnefideienlcrsraleafhcdpaawgvnvqpysgspanfaaytal
lqphdrimgldlpsgghlthgyytsggkkisatsiyfeslpykvnfttgyidydkleeka
ldfrpkllicggsayprdwdyarfraiadkvgalllcdmahisglvaaqeaanpfeycdv
vtttthkslrgpragmifyrkgpkppkkgqpegavydfedkinfavfpalqggphnhqig
alavalkqantpgfkvyakqvkanavalgnylmskgyqivtngtenhlvlwdlrplgltg
nkveklcdlcsitlnknavfgdssalapggvrigapamtsrglvekdfeqigeflsravt
ltldiqktygkllkdfnkglvnnkdldqlkadvekfsasyempgflmsemkykd

    Sequence, based on observed residues (ATOM records): (download) 
    >6smrB (B:)
amepvsswgntslvsvdpeihdliekekrrqcrgieliasenftsfaviealgsaltnky
segipgnryyggnefideienlcrsraleafhcdpaawgvnvqpysgspanfaaytallq
phdrimgldlpsgghlthgyytsggkkisatsiyfeslpykvnfttgyidydkleekald
frpkllicggsayprdwdyarfraiadkvgalllcdmahisglvaaqeaanpfeycdvvt
ttthkslrgpragmifyrkgpkppkkgqpegavydfedkinfavfpalqggphnhqigal
avalkqantpgfkvyakqvkanavalgnylmskgyqivtngtenhlvlwdlrplgltgnk
veklcdlcsitlnknavfgdssalapggvrigapamtsrglvekdfeqigeflsravtlt
ldiqktygkllkdfnkglvnnkdldqlkadvekfsasyempgflmsemkykd

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6smrC (C:)
snamepvsswgntslvsvdpeihdliekekrrqcrgieliasenftsfaviealgsaltn
kysegipgnryyggnefideienlcrsraleafhcdpaawgvnvqpysgspanfaaytal
lqphdrimgldlpsgghlthgyytsggkkisatsiyfeslpykvnfttgyidydkleeka
ldfrpkllicggsayprdwdyarfraiadkvgalllcdmahisglvaaqeaanpfeycdv
vtttthkslrgpragmifyrkgpkppkkgqpegavydfedkinfavfpalqggphnhqig
alavalkqantpgfkvyakqvkanavalgnylmskgyqivtngtenhlvlwdlrplgltg
nkveklcdlcsitlnknavfgdssalapggvrigapamtsrglvekdfeqigeflsravt
ltldiqktygkllkdfnkglvnnkdldqlkadvekfsasyempgflmsemkykd

    Sequence, based on observed residues (ATOM records): (download) 
    >6smrC (C:)
amepvsswgntslvsvdpeihdliekekrrqcrgieliasenftsfaviealgsaltnky
segipgnryyggnefideienlcrsraleafhcdpaawgvnvqpysgspanfaaytallq
phdrimgldlpsgghlthgyytsggkkisatsiyfeslpykvnfttgyidydkleekald
frpkllicggsayprdwdyarfraiadkvgalllcdmahisglvaaqeaanpfeycdvvt
ttthkslrgpragmifyrkgpkppkkgqpegavydfedkinfavfpalqggphnhqigal
avalkqantpgfkvyakqvkanavalgnylmskgyqivtngtenhlvlwdlrplgltgnk
veklcdlcsitlnknavfgdssalapggvrigapamtsrglvekdfeqigeflsravtlt
ldiqktygkllkdfnkglvnnkdldqlkadvekfsasyempgflmsemkyk

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6smrD (D:)
snamepvsswgntslvsvdpeihdliekekrrqcrgieliasenftsfaviealgsaltn
kysegipgnryyggnefideienlcrsraleafhcdpaawgvnvqpysgspanfaaytal
lqphdrimgldlpsgghlthgyytsggkkisatsiyfeslpykvnfttgyidydkleeka
ldfrpkllicggsayprdwdyarfraiadkvgalllcdmahisglvaaqeaanpfeycdv
vtttthkslrgpragmifyrkgpkppkkgqpegavydfedkinfavfpalqggphnhqig
alavalkqantpgfkvyakqvkanavalgnylmskgyqivtngtenhlvlwdlrplgltg
nkveklcdlcsitlnknavfgdssalapggvrigapamtsrglvekdfeqigeflsravt
ltldiqktygkllkdfnkglvnnkdldqlkadvekfsasyempgflmsemkykd

    Sequence, based on observed residues (ATOM records): (download) 
    >6smrD (D:)
amepvsswgntslvsvdpeihdliekekrrqcrgieliasenftsfaviealgsaltnky
segipgnryyggnefideienlcrsraleafhcdpaawgvnvqpysgspanfaaytallq
phdrimgldlpsgghlthgyytsggkkisatsiyfeslpykvnfttgyidydkleekald
frpkllicggsayprdwdyarfraiadkvgalllcdmahisglvaaqeaanpfeycdvvt
ttthkslrgpragmifyrkgpkppkkgqpegavydfedkinfavfpalqggphnhqigal
avalkqantpgfkvyakqvkanavalgnylmskgyqivtngtenhlvlwdlrplgltgnk
veklcdlcsitlnknavfgdssalapggvrigapamtsrglvekdfeqigeflsravtlt
ldiqktygkllkdfnkglvnnkdldqlkadvekfsasyempgflmsemkyk