PDB entry 6pgo

View 6pgo on RCSB PDB site
Description: Crystal structure of human KRAS G12C covalently bound to a phthalazine inhibitor
Class: SIGNALING PROTEIN/Inhibitor
Keywords: Inhibitor, GTPase, SIGNALING PROTEIN, SIGNALING PROTEIN-Inhibitor complex
Deposited on 2019-06-24, released 2019-12-25
The last revision prior to the SCOPe 2.07 freeze date was dated 2019-12-25, with a file datestamp of 2019-12-20.
Experiment type: XRAY
Resolution: 1.6 Å
R-factor: N/A
AEROSPACI score: 0.45 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: GTPase KRas
    Species: Homo sapiens [TaxId:9606]
    Gene: KRAS, KRAS2, RASK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01116 (14-End)
      • variant (25)
      • engineered mutation (64)
      • engineered mutation (93)
      • engineered mutation (131)
    Domains in SCOPe 2.07: d6pgoa_
  • Chain 'B':
    Compound: GTPase KRas
    Species: Homo sapiens [TaxId:9606]
    Gene: KRAS, KRAS2, RASK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01116 (14-182)
      • variant (25)
      • engineered mutation (64)
      • engineered mutation (93)
      • engineered mutation (131)
    Domains in SCOPe 2.07: d6pgob_
  • Heterogens: OJ1, MG, GDP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6pgoA (A:)
mkhhhhhhhdevdgmteyklvvvgacgvgksaltiqliqnhfvdeydptiedsyrkqvvi
dgetslldildtagqeeysamrdqymrtgegfllvfainntksfedihhyreqikrvkds
edvpmvlvgnksdlpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkh
kek

    Sequence, based on observed residues (ATOM records): (download) 
    >6pgoA (A:)
mteyklvvvgacgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetslldildtag
rdqymrtgegfllvfainntksfedihhyreqikrvkdsedvpmvlvgnksdlpsrtvdt
kqaqdlarsygipfietsaktrqgvddafytlvreirkhk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6pgoB (B:)
mkhhhhhhhdevdgmteyklvvvgacgvgksaltiqliqnhfvdeydptiedsyrkqvvi
dgetslldildtagqeeysamrdqymrtgegfllvfainntksfedihhyreqikrvkds
edvpmvlvgnksdlpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkh
kek

    Sequence, based on observed residues (ATOM records): (download) 
    >6pgoB (B:)
mteyklvvvgacgvgksaltiqliqnhfvdesyrkqvvidgetslldildtdqymrtgeg
fllvfainntksfedihhyreqikrvkdsedvpmvlvgnksdlpsrtvdtkqaqdlarsy
gipfietsaktrqgvddafytlvreirkhkek