PDB entry 6ox7

View 6ox7 on RCSB PDB site
Description: The complex of 1918 NS1-ED and the iSH2 domain of the human p85beta subunit of PI3K
Class: viral protein
Keywords: NS1, p85-beta, PI3K, 1918, VIRAL PROTEIN
Deposited on 2019-05-13, released 2020-04-22
The last revision prior to the SCOPe 2.07 freeze date was dated 2020-04-22, with a file datestamp of 2020-04-17.
Experiment type: XRAY
Resolution: 2.75 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Non-structural protein 1
    Species: Influenza A virus (strain A/Brevig Mission/1/1918 H1N1) [TaxId:88776]
    Gene: NS
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q99AU3 (0-End)
      • engineered mutation (101)
    Domains in SCOPe 2.07: d6ox7a_
  • Chain 'B':
    Compound: Non-structural protein 1
    Species: Influenza A virus (strain A/Brevig Mission/1/1918 H1N1) [TaxId:88776]
    Gene: NS
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q99AU3 (0-End)
      • engineered mutation (101)
    Domains in SCOPe 2.07: d6ox7b_
  • Chain 'C':
    Compound: Phosphatidylinositol 3-kinase regulatory subunit beta
    Species: Homo sapiens [TaxId:9606]
    Gene: PIK3R2
    Database cross-references and differences (RAF-indexed):
    • Uniprot O00459 (2-164)
      • expression tag (0-1)
  • Chain 'D':
    Compound: Phosphatidylinositol 3-kinase regulatory subunit beta
    Species: Homo sapiens [TaxId:9606]
    Gene: PIK3R2
    Database cross-references and differences (RAF-indexed):
    • Uniprot O00459 (2-164)
      • expression tag (0-1)
    Domains in SCOPe 2.07: d6ox7d1, d6ox7d2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6ox7A (A:)
asryltdmtleemsrdwfmlmpkqkvagslcirmdqaimdkniilkanfsvifdrletli
llrafteegaivgeisplpslpghtdedvknavgvligglerndntvrvsetlqrfawrs
snengrpplppkqkrkmartiksev

    Sequence, based on observed residues (ATOM records): (download) 
    >6ox7A (A:)
asryltdmtleemsrdwfmlmpkqkvagslcirmdqaimdkniilkanfsvifdrletli
llrafteegaivgeisplpslpghtdedvknavgvligglerndntvrvsetlqrfawrs
snengrp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6ox7B (B:)
asryltdmtleemsrdwfmlmpkqkvagslcirmdqaimdkniilkanfsvifdrletli
llrafteegaivgeisplpslpghtdedvknavgvligglerndntvrvsetlqrfawrs
snengrpplppkqkrkmartiksev

    Sequence, based on observed residues (ATOM records): (download) 
    >6ox7B (B:)
asryltdmtleemsrdwfmlmpkqkvagslcirmdqaimdkniilkanfsvifdrletli
llrafteegaivgeisplpslpghtdedvknavgvligglerndntvrvsetlqrfawr

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6ox7D (D:)
gskedsveavgaqlkvyhqqyqdksreydqlyeeytrtsqelqmkrtaieafnetikife
eqgqtqeksskeylerfrregnekemqrillnserlksriaeihesrtkleqqlraqasd
nreidkrmnslkpdlmqlrkirdqylvwltqkgarqkkinewlgi

    Sequence, based on observed residues (ATOM records): (download) 
    >6ox7D (D:)
gskedsveavgaqlkvyhqqyqdksreydqlyeeytrtsqelqmkrtaieafnetikife
eqgqtqeillnserlksriaeihesrtkleqqlraqasdnreidkrmnslkpdlmqlrki
rdqylvwltqkgarqkkinewlgi