PDB entry 6oc0

View 6oc0 on RCSB PDB site
Description: Crystal structure of human DHODH with OSU-03012
Class: oxidoreductase/oxidoreductase inhibitor
Keywords: DHODH, Inhibitor, OSU-03012, OXIDOREDUCTASE, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex
Deposited on 2019-03-21, released 2019-11-13
The last revision prior to the SCOPe 2.07 freeze date was dated 2019-11-13, with a file datestamp of 2019-11-08.
Experiment type: XRAY
Resolution: 1.4 Å
R-factor: N/A
AEROSPACI score: 0.53 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dihydroorotate dehydrogenase (quinone), mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: DHODH
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6oc0a_
  • Heterogens: ORO, FMN, SO4, M4J, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6oc0A (A:)
hmmatgderfyaehlmptlqglldpesahrlavrftslgllprarfqdsdmlevrvlghk
frnpvgiaagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinry
gfnshglsvvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgplad
ylvvnvsspntaglrslqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdked
iasvvkelgidglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgr
vpiigvggvssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvt
daigadhrr

    Sequence, based on observed residues (ATOM records): (download) 
    >6oc0A (A:)
atgderfyaehlmptlqglldpesahrlavrftslgllprarfqdsdmlevrvlghkfrn
pvgiaagfdkhgeavdglykmgfgfveigsvtpkpqegnprprvfrlpedqavinrygfn
shglsvvehrlrarqqkqakltedglplgvnlgknktsvdaaedyaegvrvlgpladylv
vnvsspntaglrslqgkaelrrlltkvlqerdglrrvhrpavlvkiapdltsqdkedias
vvkelgidglivtnttvsrpaglqgalrsetgglsgkplrdlstqtiremyaltqgrvpi
igvggvssgqdalekiragaslvqlytaltfwgppvvgkvkreleallkeqgfggvtdai
gadhr