PDB entry 6npf

View 6npf on RCSB PDB site
Description: Structure of E.coli enolase in complex with an analog of the natural product SF-2312 metabolite.
Class: lyase
Keywords: Natural inhibitor, complex, enolase, SF2312, LYASE
Deposited on 2019-01-17, released 2019-11-27
The last revision prior to the SCOPe 2.07 freeze date was dated 2019-11-27, with a file datestamp of 2019-11-22.
Experiment type: XRAY
Resolution: 2.57 Å
R-factor: N/A
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: enolase
    Species: Escherichia coli [TaxId:562]
    Gene: eno, ECS88_3047
    Database cross-references and differences (RAF-indexed):
    • Uniprot B7MLA0 (17-End)
      • expression tag (10-16)
    Domains in SCOPe 2.07: d6npfa1, d6npfa2, d6npfa3
  • Chain 'B':
    Compound: enolase
    Species: Escherichia coli [TaxId:562]
    Gene: eno, ECS88_3047
    Database cross-references and differences (RAF-indexed):
    • Uniprot B7MLA0 (17-End)
      • expression tag (10-16)
    Domains in SCOPe 2.07: d6npfb1, d6npfb2, d6npfb3
  • Chain 'C':
    Compound: enolase
    Species: Escherichia coli [TaxId:562]
    Gene: eno, ECS88_3047
    Database cross-references and differences (RAF-indexed):
    • Uniprot B7MLA0 (17-End)
      • expression tag (10-16)
    Domains in SCOPe 2.07: d6npfc1, d6npfc2, d6npfc3
  • Chain 'D':
    Compound: enolase
    Species: Escherichia coli [TaxId:562]
    Gene: eno, ECS88_3047
    Database cross-references and differences (RAF-indexed):
    • Uniprot B7MLA0 (17-End)
      • expression tag (10-16)
    Domains in SCOPe 2.07: d6npfd1, d6npfd2, d6npfd3
  • Chain 'E':
    Compound: enolase
    Species: Escherichia coli [TaxId:562]
    Gene: eno, ECS88_3047
    Database cross-references and differences (RAF-indexed):
    • Uniprot B7MLA0 (17-End)
      • expression tag (10-16)
    Domains in SCOPe 2.07: d6npfe1, d6npfe2, d6npfe3
  • Chain 'F':
    Compound: enolase
    Species: Escherichia coli [TaxId:562]
    Gene: eno, ECS88_3047
    Database cross-references and differences (RAF-indexed):
    • Uniprot B7MLA0 (17-End)
      • expression tag (10-16)
    Domains in SCOPe 2.07: d6npff1, d6npff2, d6npff3
  • Heterogens: KVM, TLA, SO4, MG, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6npfA (A:)
gshmasmtggqqmgrgsmskivkiigreiidsrgnptveaevhleggfvgmaaapsgast
gsrealelrdgdksrflgkgvtkavaavngpiaqaligkdakdqagidkimidldgtenk
skfganailavslanakaaaaakgmplyehiaelngtpgkysmpvpmmniinggehadnn
vdiqefmiqpvgaktvkeairmgsevfhhlakvlkakgmntavgdeggyapnlgsnaeal
aviaeavkaagyelgkditlamdcaasefykdgkyvlagegnkaftseefthfleeltkq
ypivsiedgldesdwdgfayqtkvlgdkiqlvgddlfvtntkilkegiekgiansilikf
nqigsltetlaaikmakdagytavishrsgetedatiadlavgtaagqiktgsmsrsdrv
akynqlirieealgekapyngrkeikgqa

    Sequence, based on observed residues (ATOM records): (download) 
    >6npfA (A:)
qqmgrgsmskivkiigreiidsrgnptveaevhleggfvgmaaapsgastgsrealelrd
gdksrflgkgvtkavaavngpiaqaligkdakdqagidkimidldgtenkskfganaila
vslanakaaaaakgmplyehiaelngtpgkysmpvpmmniinggehadnnvdiqefmiqp
vgaktvkeairmgsevfhhlakvlkakgmntavgdeggyapnlgsnaealaviaeavkaa
gyelgkditlamdcaasefykdgkyvlagegnkaftseefthfleeltkqypivsiedgl
desdwdgfayqtkvlgdkiqlvgddlfvtntkilkegiekgiansilikfnqigsltetl
aaikmakdagytavishrsgetedatiadlavgtaagqiktgsmsrsdrvakynqlirie
ealgekapyngrkeikgq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6npfB (B:)
gshmasmtggqqmgrgsmskivkiigreiidsrgnptveaevhleggfvgmaaapsgast
gsrealelrdgdksrflgkgvtkavaavngpiaqaligkdakdqagidkimidldgtenk
skfganailavslanakaaaaakgmplyehiaelngtpgkysmpvpmmniinggehadnn
vdiqefmiqpvgaktvkeairmgsevfhhlakvlkakgmntavgdeggyapnlgsnaeal
aviaeavkaagyelgkditlamdcaasefykdgkyvlagegnkaftseefthfleeltkq
ypivsiedgldesdwdgfayqtkvlgdkiqlvgddlfvtntkilkegiekgiansilikf
nqigsltetlaaikmakdagytavishrsgetedatiadlavgtaagqiktgsmsrsdrv
akynqlirieealgekapyngrkeikgqa

    Sequence, based on observed residues (ATOM records): (download) 
    >6npfB (B:)
qqmgrgsmskivkiigreiidsrgnptveaevhleggfvgmaaapsgastgsrealelrd
gdksrflgkgvtkavaavngpiaqaligkdakdqagidkimidldgtenkskfganaila
vslanakaaaaakgmplyehiaelngtpgkysmpvpmmniinggednnvdiqefmiqpvg
aktvkeairmgsevfhhlakvlkakgmntavgdeggyapnlgsnaealaviaeavkaagy
elgkditlamdcaasefykdgkyvlagegnkaftseefthfleeltkqypivsiedglde
sdwdgfayqtkvlgdkiqlvgddlfvtntkilkegiekgiansilikfnqigsltetlaa
ikmakdagytavishrsgetedatiadlavgtaagqiktgsmsrsdrvakynqlirieea
lgekapyngrkeikgq

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6npfC (C:)
gshmasmtggqqmgrgsmskivkiigreiidsrgnptveaevhleggfvgmaaapsgast
gsrealelrdgdksrflgkgvtkavaavngpiaqaligkdakdqagidkimidldgtenk
skfganailavslanakaaaaakgmplyehiaelngtpgkysmpvpmmniinggehadnn
vdiqefmiqpvgaktvkeairmgsevfhhlakvlkakgmntavgdeggyapnlgsnaeal
aviaeavkaagyelgkditlamdcaasefykdgkyvlagegnkaftseefthfleeltkq
ypivsiedgldesdwdgfayqtkvlgdkiqlvgddlfvtntkilkegiekgiansilikf
nqigsltetlaaikmakdagytavishrsgetedatiadlavgtaagqiktgsmsrsdrv
akynqlirieealgekapyngrkeikgqa

    Sequence, based on observed residues (ATOM records): (download) 
    >6npfC (C:)
qqmgrgsmskivkiigreiidsrgnptveaevhleggfvgmaaapsgastgsrealelrd
gdksrflgkgvtkavaavngpiaqaligkdakdqagidkimidldgtenkskfganaila
vslanakaaaaakgmplyehiaelngtpgkysmpvpmmniinggehadnnvdiqefmiqp
vgaktvkeairmgsevfhhlakvlkakgmntavgdeggyapnlgsnaealaviaeavkaa
gyelgkditlamdcaasefykdgkyvlagegnkaftseefthfleeltkqypivsiedgl
desdwdgfayqtkvlgdkiqlvgddlfvtntkilkegiekgiansilikfnqigsltetl
aaikmakdagytavishrsgetedatiadlavgtaagqiktgsmsrsdrvakynqlirie
ealgekapyngrkeikgq

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6npfD (D:)
gshmasmtggqqmgrgsmskivkiigreiidsrgnptveaevhleggfvgmaaapsgast
gsrealelrdgdksrflgkgvtkavaavngpiaqaligkdakdqagidkimidldgtenk
skfganailavslanakaaaaakgmplyehiaelngtpgkysmpvpmmniinggehadnn
vdiqefmiqpvgaktvkeairmgsevfhhlakvlkakgmntavgdeggyapnlgsnaeal
aviaeavkaagyelgkditlamdcaasefykdgkyvlagegnkaftseefthfleeltkq
ypivsiedgldesdwdgfayqtkvlgdkiqlvgddlfvtntkilkegiekgiansilikf
nqigsltetlaaikmakdagytavishrsgetedatiadlavgtaagqiktgsmsrsdrv
akynqlirieealgekapyngrkeikgqa

    Sequence, based on observed residues (ATOM records): (download) 
    >6npfD (D:)
qqmgrgsmskivkiigreiidsrgnptveaevhleggfvgmaaapsgastgsrealelrd
gdksrflgkgvtkavaavngpiaqaligkdakdqagidkimidldgtenkskfganaila
vslanakaaaaakgmplyehiaelngtpgkysmpvpmmniinggdndiqefmiqpvgakt
vkeairmgsevfhhlakvlkakgmntavgdeggyapnlgsnaealaviaeavkaagyelg
kditlamdcaasefykdgkyvlagenkaftseefthfleeltkqypivsiedgldesdwd
gfayqtkvlgdkiqlvgddlfvtntkilkegiekgiansilikfnqigsltetlaaikma
kdagytavishrsgetedatiadlavgtaagqiktgsmsrsdrvakynqlirieealgek
apyngrkeikgq

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6npfE (E:)
gshmasmtggqqmgrgsmskivkiigreiidsrgnptveaevhleggfvgmaaapsgast
gsrealelrdgdksrflgkgvtkavaavngpiaqaligkdakdqagidkimidldgtenk
skfganailavslanakaaaaakgmplyehiaelngtpgkysmpvpmmniinggehadnn
vdiqefmiqpvgaktvkeairmgsevfhhlakvlkakgmntavgdeggyapnlgsnaeal
aviaeavkaagyelgkditlamdcaasefykdgkyvlagegnkaftseefthfleeltkq
ypivsiedgldesdwdgfayqtkvlgdkiqlvgddlfvtntkilkegiekgiansilikf
nqigsltetlaaikmakdagytavishrsgetedatiadlavgtaagqiktgsmsrsdrv
akynqlirieealgekapyngrkeikgqa

    Sequence, based on observed residues (ATOM records): (download) 
    >6npfE (E:)
qqmgrgsmskivkiigreiidsrgnptveaevhleggfvgmaaapsgastgsrealelrd
gdksrflgkgvtkavaavngpiaqaligkdakdqagidkimidldgtenkskfganaila
vslanakaaaaakgmplyehiaelngtpgkysmpvpmmniingdiqefmiqpvgaktvke
airmgsevfhhlakvlkakgmntavgdeggyapnlgsnaealaviaeavkaagyelgkdi
tlamdcaasefykdgkyvlankftseefthfleeltkqypivsiedgldesdwdgfayqt
kvlgdkiqlvgddlfvtntkilkegiekgiansilikfnqigsltetlaaikmakdagyt
avishrsgetedatiadlavgtaagqiktgsmsrsdrvakynqlirieealgekapyngr
keikgq

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6npfF (F:)
gshmasmtggqqmgrgsmskivkiigreiidsrgnptveaevhleggfvgmaaapsgast
gsrealelrdgdksrflgkgvtkavaavngpiaqaligkdakdqagidkimidldgtenk
skfganailavslanakaaaaakgmplyehiaelngtpgkysmpvpmmniinggehadnn
vdiqefmiqpvgaktvkeairmgsevfhhlakvlkakgmntavgdeggyapnlgsnaeal
aviaeavkaagyelgkditlamdcaasefykdgkyvlagegnkaftseefthfleeltkq
ypivsiedgldesdwdgfayqtkvlgdkiqlvgddlfvtntkilkegiekgiansilikf
nqigsltetlaaikmakdagytavishrsgetedatiadlavgtaagqiktgsmsrsdrv
akynqlirieealgekapyngrkeikgqa

    Sequence, based on observed residues (ATOM records): (download) 
    >6npfF (F:)
qqmgrgsmskivkiigreiidsrgnptveaevhleggfvgmaaapsgastgsrealelrd
gdksrflgkgvtkavaavngpiaqaligkdakdqagidkimidldgtenkskfganaila
vslanakaaaaakgmplyehiaelngtpgkysmpvpmmniinggedndiqefmiqpvgak
tvkeairmgsevfhhlakvlkakgmntavgdeggyapnlgsnaealaviaeavkaagyel
gkditlamdcaasefykdgkyvlagegnkaftseefthfleeltkqypivsiedgldesd
wdgfayqtkvlgdkiqlvgddlfvtntkilkegiekgiansilikfnqigsltetlaaik
makdagytavishrsgetedatiadlavgtaagqiktgsmsrsdrvakynqlirieealg
ekapyngrkeikgq