PDB entry 6lem
View 6lem on RCSB PDB site
Description: Structure of E. coli beta-glucuronidase complex with C6-nonyl uronic isofagomine
Class: hydrolase
Keywords: inhibitor, isofagomine, glycosidase, HYDROLASE
Deposited on
2019-11-25, released
2021-01-27
The last revision prior to the SCOPe 2.07 freeze date was dated
2021-01-27, with a file datestamp of
2021-01-22.
Experiment type: XRAY
Resolution: 3.19 Å
R-factor: N/A
AEROSPACI score: 0.17
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Beta-D-glucuronidase
Species: Escherichia coli [TaxId:562]
Gene: uidA, A9R57_02750, ACN68_26240, ACN81_11215, ACU57_22480, AM270_03870, AM464_25945, AUQ13_03930, BANRA_00079, BANRA_00563, BANRA_02251, BB545_08625, BET08_08370, BHS87_09195, BJJ90_13245, BK292_18725, BOH76_23450, BON63_17270, BON69_09035, BON71_25965, BUE81_02440, BvCms2454_03287, BvCmsHHP019_03955, BvCmsKKP061_00687, BvCmsKSP011_01150, BvCmsKSP024_03693, BvCmsKSP026_03508, BvCmsKSP045_00685, BvCmsKSP067_00118, BvCmsNSP047_02620, BvCmsSINP012_02859, BvCmsSIP019_00145, BVL39_19890, BW690_15740, BZL31_05290, C4J69_24575, C5N07_00485, C7235_11830, C9200_15785, C9E25_02740, C9Z12_02165, CA593_19915, CI694_12700, COD46_02605, CV83915_04776, D2185_18760, D3821_14300, D3Y67_19800, D9D20_10680, D9I11_03210, D9K48_06425, DBQ99_12860, DNQ41_12380, DXT69_06115, DXT71_07500, E2119_03270, E5P28_03750, E5S47_08220, EAI46_18055, EAI52_05705, EC3234A_33c01180, EC3426_02616, EEP23_13620, EL75_2040, EL79_2080, EL80_2107, ELT20_01525, EPS71_15340, ERS085365_00730, ERS085416_00883, ERS139211_01060, ERS150873_00637, EXX24_04480, EXX78_14190, EYD11_10940, EYY78_00120, FAX15_15905, FV293_04650, NCTC11181_05093, NCTC13462_05935, NCTC8500_02703, NCTC9045_02849, NCTC9062_00385, NCTC9706_03872, PU06_11555, RG28_14030, RK56_009440, SAMEA3472044_02684, SAMEA3472047_01270, SAMEA3472080_01417, SAMEA3484427_00776, SAMEA3484429_00887, SAMEA3752553_00640, SAMEA3752559_02259, SAMEA3753097_02320, SK85_01835, WR15_14365
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d6lema1, d6lema2, d6lema3, d6lema4 - Chain 'B':
Compound: Beta-D-glucuronidase
Species: Escherichia coli [TaxId:562]
Gene: uidA, A9R57_02750, ACN68_26240, ACN81_11215, ACU57_22480, AM270_03870, AM464_25945, AUQ13_03930, BANRA_00079, BANRA_00563, BANRA_02251, BB545_08625, BET08_08370, BHS87_09195, BJJ90_13245, BK292_18725, BOH76_23450, BON63_17270, BON69_09035, BON71_25965, BUE81_02440, BvCms2454_03287, BvCmsHHP019_03955, BvCmsKKP061_00687, BvCmsKSP011_01150, BvCmsKSP024_03693, BvCmsKSP026_03508, BvCmsKSP045_00685, BvCmsKSP067_00118, BvCmsNSP047_02620, BvCmsSINP012_02859, BvCmsSIP019_00145, BVL39_19890, BW690_15740, BZL31_05290, C4J69_24575, C5N07_00485, C7235_11830, C9200_15785, C9E25_02740, C9Z12_02165, CA593_19915, CI694_12700, COD46_02605, CV83915_04776, D2185_18760, D3821_14300, D3Y67_19800, D9D20_10680, D9I11_03210, D9K48_06425, DBQ99_12860, DNQ41_12380, DXT69_06115, DXT71_07500, E2119_03270, E5P28_03750, E5S47_08220, EAI46_18055, EAI52_05705, EC3234A_33c01180, EC3426_02616, EEP23_13620, EL75_2040, EL79_2080, EL80_2107, ELT20_01525, EPS71_15340, ERS085365_00730, ERS085416_00883, ERS139211_01060, ERS150873_00637, EXX24_04480, EXX78_14190, EYD11_10940, EYY78_00120, FAX15_15905, FV293_04650, NCTC11181_05093, NCTC13462_05935, NCTC8500_02703, NCTC9045_02849, NCTC9062_00385, NCTC9706_03872, PU06_11555, RG28_14030, RK56_009440, SAMEA3472044_02684, SAMEA3472047_01270, SAMEA3472080_01417, SAMEA3484427_00776, SAMEA3484429_00887, SAMEA3752553_00640, SAMEA3752559_02259, SAMEA3753097_02320, SK85_01835, WR15_14365
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d6lemb1, d6lemb2, d6lemb3 - Heterogens: E9O
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>6lemA (A:)
shmlrpvetptreikkldglwafsldrencgidqrwwesalqesraiavpgsfndqfada
dirnyagnvwyqrevfipkgwagqrivlrfdavthygkvwvnnqevmehqggytpfeadv
tpyviagksvritvcvnnelnwqtippgmvitdengkkkqsyfhdffnyagihrsvmlyt
tpntwvdditvvthvaqdcnhasvdwqvvangdvsvelrdadqqvvatgqgtsgtlqvvn
phlwqpgegylyelcvtaksqtecdiyplrvgirsvavkgeqflinhkpfyftgfgrhed
adlrgkgfdnvlmvhdhalmdwigansyrtshypyaeemldwadehgivvidetaavgfn
lslgigfeagnkpkelyseeavngetqqahlqaikeliardknhpsvvmwsianepdtrp
qgareyfaplaeatrkldptrpitcvnvmfcdahtdtisdlfdvlclnryygwyvqsgdl
etaekvlekellawqeklhqpiiiteygvdtlaglhsmytdmwseeyqcawldmyhrvfd
rvsavvgeqvwnfadfatsqgilrvggnkkgiftrdrkpksaafllqkrwtgmnfgekpq
qggkq
Sequence, based on observed residues (ATOM records): (download)
>6lemA (A:)
shmlrpvetptreikkldglwafsldrencgidqrwwesalqesraiavpgsfndqfada
dirnyagnvwyqrevfipkagqrivlrfdavthygkvwvnnqevmehqggytpfeadvtp
yviagksvritvcvnnelnwqtippgmvitdengkkkqsyfhdffnyagihrsvmlyttp
ntwvdditvvthvaqdcnhasvdwqvvangdvsvelrdadqqvvatgqgtsgtlqvvnph
lwqpgegylyelcvtaksqtecdiyplrvgirsvavkgeqflinhkpfyftgfgrhedad
lrgkgfdnvlmvhdhalmdwigansyrtshypyaeemldwadehgivvidetaavgfnls
lgnkpkelyseeavngetqqahlqaikeliardknhpsvvmwsianepdtrpqgareyfa
plaeatrkldptrpitcvnvmfcdahtdtisdlfdvlclnryygwyvqsgdletaekvle
kellawqeklhqpiiiteygvdtlaglhsmytdmwseeyqcawldmyhrvfdrvsavvge
qvwnfadfatsqgilrvggnkkgiftrdrkpksaafllqkrwtgmnfgekpqqgg
- Chain 'B':
Sequence, based on SEQRES records: (download)
>6lemB (B:)
rpvetptreikkldglwafsldrencgidqrwwesalqesraiavpgsfndqfadadirn
yagnvwyqrevfipkgwagqrivlrfdavthygkvwvnnqevmehqggytpfeadvtpyv
iagksvritvcvnnelnwqtippgmvitdengkkkqsyfhdffnyagihrsvmlyttpnt
wvdditvvthvaqdcnhasvdwqvvangdvsvelrdadqqvvatgqgtsgtlqvvnphlw
qpgegylyelcvtaksqtecdiyplrvgirsvavkgeqflinhkpfyftgfgrhedadlr
gkgfdnvlmvhdhalmdwigansyrtshypyaeemldwadehgivvidetaavgfnlslg
igfeagnkpkelyseeavngetqqahlqaikeliardknhpsvvmwsianepdtrpqgar
eyfaplaeatrkldptrpitcvnvmfcdahtdtisdlfdvlclnryygwyvqsgdletae
kvlekellawqeklhqpiiiteygvdtlaglhsmytdmwseeyqcawldmyhrvfdrvsa
vvgeqvwnfadfatsqgilrvggnkkgiftrdrkpksaafllqkrwtgmnfgekpqqggk
q
Sequence, based on observed residues (ATOM records): (download)
>6lemB (B:)
rpveteikkldglwafsldrencgidqrwwesalqesraiavpgsfndqfadadirnyag
nvwyqrevfipkgwagqrivlrfdavthygkvwvnnqevmehqggytpfeadvtpyviag
ksvritvcvnnelnwqtippgmvitdengkkkqsyfhdffnyagihrsvmlyttpntwvd
ditvvthvaqhasvdwqvvangdvsvelrdadqqvvatgqgtsgtlqvvwqpgegylyel
cvtaksqtecdiyplrvgirsvavkgeqflinhkpfyftgfgrhedadlrgkgfdnvlmv
hdhalmdwigansyrtshypyaeemldwadehgivvidetaavgfnlslgigkpkelyse
eavngetqqahlqaikeliardknhpsvvmwsianepdtrpqgareyfaplaeatrkldp
trpitcvnvmfcdahtdtisdlfdvlclnryygwyvqsgdletaekvlekellawqeklh
qpiiiteygvdtlaglhsmytdmwseeyqcawldmyhrvfdrvsavvgeqvwnfadfats
qgilrvggnkkgiftrdrkpksaafllqkrwtgmnfgekpqqg