PDB entry 6jl4

View 6jl4 on RCSB PDB site
Description: Crystal structure of aspartate transcarbamoylase from Trypanosoma cruzi in complex with carbamoyl aspartate (CA) and phosphate (Pi)
Class: transferase
Keywords: ATCase, Pyrimidine metabolism, TRANSFERASE
Deposited on 2019-03-04, released 2020-03-04
The last revision prior to the SCOPe 2.07 freeze date was dated 2020-03-04, with a file datestamp of 2020-02-28.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: aspartate carbamoyltransferase
    Species: Trypanosoma cruzi [TaxId:5693]
    Gene: C3747_31g124
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6jl4a1, d6jl4a2
  • Chain 'B':
    Compound: aspartate carbamoyltransferase
    Species: Trypanosoma cruzi [TaxId:5693]
    Gene: C3747_31g124
    Database cross-references and differences (RAF-indexed):
    • Uniprot O15636 (1-326)
      • expression tag (0)
    Domains in SCOPe 2.07: d6jl4b1, d6jl4b2, d6jl4b3
  • Chain 'C':
    Compound: aspartate carbamoyltransferase
    Species: Trypanosoma cruzi [TaxId:5693]
    Gene: C3747_31g124
    Database cross-references and differences (RAF-indexed):
    • Uniprot O15636 (1-326)
      • expression tag (0)
    Domains in SCOPe 2.07: d6jl4c1, d6jl4c2, d6jl4c3
  • Chain 'D':
    Compound: aspartate carbamoyltransferase
    Species: Trypanosoma cruzi [TaxId:5693]
    Gene: C3747_31g124
    Database cross-references and differences (RAF-indexed):
    • Uniprot O15636 (1-326)
      • expression tag (0)
    Domains in SCOPe 2.07: d6jl4d1, d6jl4d2, d6jl4d3
  • Chain 'E':
    Compound: aspartate carbamoyltransferase
    Species: Trypanosoma cruzi [TaxId:5693]
    Gene: C3747_31g124
    Database cross-references and differences (RAF-indexed):
    • Uniprot O15636 (1-326)
      • expression tag (0)
    Domains in SCOPe 2.07: d6jl4e1, d6jl4e2, d6jl4e3
  • Chain 'F':
    Compound: aspartate carbamoyltransferase
    Species: Trypanosoma cruzi [TaxId:5693]
    Gene: C3747_31g124
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d6jl4f1, d6jl4f2
  • Heterogens: NCD, PO4, ASP, CP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6jl4A (A:)
smlelppvaslkgksitsaeqfsradiyalihlasamqrkidagevlnllqgrimtplff
edssrtfssfcaamirlggsvvnfkveassinkgetladtirtldsysdvlvmrhprqda
ieealsvaqhpilnagngagehptqalldtltihselgsvdgitialigdlkmgrtvhsl
lkllvrnfsikcvflvapdalqmpqdvleplqheiatkgviihrthaltdevmqksdvly
ttrlqkerfmastsddaaalqsfaakaditidaarmrlakekmivmhplprndelsttvd
adpraayfrqmrygmfmrmailwsvla

    Sequence, based on observed residues (ATOM records): (download) 
    >6jl4A (A:)
mlelppvaslkgksitsaeqfsradiyalihlasamqrkidagevlnllqgrimtplffe
dssrtfssfcaamirlggsvvnfkveassinkgetladtirtldsysdvlvmrhprqdai
eealsvaqhpilnagngagehptqalldtltihselgsvdgitialigdlkmgrtvhsll
kllvrnfsikcvflvapdalqmpqdvleplqheiatkgviihrthaltdevmqksdvlyt
trlqakaditidaarmrlakekmivmhplprndelsttvdadpraayfrqmrygmfmrma
ilwsvla

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6jl4B (B:)
smlelppvaslkgksitsaeqfsradiyalihlasamqrkidagevlnllqgrimtplff
edssrtfssfcaamirlggsvvnfkveassinkgetladtirtldsysdvlvmrhprqda
ieealsvaqhpilnagngagehptqalldtltihselgsvdgitialigdlkmgrtvhsl
lkllvrnfsikcvflvapdalqmpqdvleplqheiatkgviihrthaltdevmqksdvly
ttrlqkerfmastsddaaalqsfaakaditidaarmrlakekmivmhplprndelsttvd
adpraayfrqmrygmfmrmailwsvla

    Sequence, based on observed residues (ATOM records): (download) 
    >6jl4B (B:)
smlelppvaslkgksitsaeqfsradiyalihlasamqrkidagevlnllqgrimtplff
edssrtfssfcaamirlggsvvnfkveassinkgetladtirtldsysdvlvmrhprqda
ieealsvaqhpilnagngagehptqalldtltihselgsvdgitialigdlkmgrtvhsl
lkllvrnfsikcvflvapdalqmpqdvleplqheiatkgviihrthaltdevmqksdvly
ttrlqkddaaalqsfaakaditidaarmrlakekmivmhplprndelsttvdadpraayf
rqmrygmfmrmailwsvla

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6jl4C (C:)
smlelppvaslkgksitsaeqfsradiyalihlasamqrkidagevlnllqgrimtplff
edssrtfssfcaamirlggsvvnfkveassinkgetladtirtldsysdvlvmrhprqda
ieealsvaqhpilnagngagehptqalldtltihselgsvdgitialigdlkmgrtvhsl
lkllvrnfsikcvflvapdalqmpqdvleplqheiatkgviihrthaltdevmqksdvly
ttrlqkerfmastsddaaalqsfaakaditidaarmrlakekmivmhplprndelsttvd
adpraayfrqmrygmfmrmailwsvla

    Sequence, based on observed residues (ATOM records): (download) 
    >6jl4C (C:)
smlelppvaslkgksitsaeqfsradiyalihlasamqrkidagevlnllqgrimtplff
edssrtfssfcaamirlggsvvnfkveassinkgetladtirtldsysdvlvmrhprqda
ieealsvaqhpilnagngagehptqalldtltihselgsvdgitialigdlkmgrtvhsl
lkllvrnfsikcvflvapdalqmpqdvleplqheiatkgviihrthaltdevmqksdvly
ttrlqkertsddaaalqsfaakaditidaarmrlakekmivmhplprndelsttvdadpr
aayfrqmrygmfmrmailwsvla

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6jl4D (D:)
smlelppvaslkgksitsaeqfsradiyalihlasamqrkidagevlnllqgrimtplff
edssrtfssfcaamirlggsvvnfkveassinkgetladtirtldsysdvlvmrhprqda
ieealsvaqhpilnagngagehptqalldtltihselgsvdgitialigdlkmgrtvhsl
lkllvrnfsikcvflvapdalqmpqdvleplqheiatkgviihrthaltdevmqksdvly
ttrlqkerfmastsddaaalqsfaakaditidaarmrlakekmivmhplprndelsttvd
adpraayfrqmrygmfmrmailwsvla

    Sequence, based on observed residues (ATOM records): (download) 
    >6jl4D (D:)
smlelppvaslkgksitsaeqfsradiyalihlasamqrkidagevlnllqgrimtplff
edssrtfssfcaamirlggsvvnfkveassinkgetladtirtldsysdvlvmrhprqda
ieealsvaqhpilnagngagehptqalldtltihselgsvdgitialigdlkmgrtvhsl
lkllvrnfsikcvflvapdalqmpqdvleplqheiatkgviihrthaltdevmqksdvly
ttrlqkeraaalqsfaakaditidaarmrlakekmivmhplprndelsttvdadpraayf
rqmrygmfmrmailwsvla

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >6jl4E (E:)
smlelppvaslkgksitsaeqfsradiyalihlasamqrkidagevlnllqgrimtplff
edssrtfssfcaamirlggsvvnfkveassinkgetladtirtldsysdvlvmrhprqda
ieealsvaqhpilnagngagehptqalldtltihselgsvdgitialigdlkmgrtvhsl
lkllvrnfsikcvflvapdalqmpqdvleplqheiatkgviihrthaltdevmqksdvly
ttrlqkerfmastsddaaalqsfaakaditidaarmrlakekmivmhplprndelsttvd
adpraayfrqmrygmfmrmailwsvla

    Sequence, based on observed residues (ATOM records): (download) 
    >6jl4E (E:)
smlelppvaslkgksitsaeqfsradiyalihlasamqrkidagevlnllqgrimtplff
edssrtfssfcaamirlggsvvnfkveassinkgetladtirtldsysdvlvmrhprqda
ieealsvaqhpilnagngagehptqalldtltihselgsvdgitialigdlkmgrtvhsl
lkllvrnfsikcvflvapdalqmpqdvleplqheiatkgviihrthaltdevmqksdvly
ttrlqkerfaditidaarmrlakekmivmhplprndelsttvdadpraayfrqmrygmfm
rmailwsvla

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >6jl4F (F:)
smlelppvaslkgksitsaeqfsradiyalihlasamqrkidagevlnllqgrimtplff
edssrtfssfcaamirlggsvvnfkveassinkgetladtirtldsysdvlvmrhprqda
ieealsvaqhpilnagngagehptqalldtltihselgsvdgitialigdlkmgrtvhsl
lkllvrnfsikcvflvapdalqmpqdvleplqheiatkgviihrthaltdevmqksdvly
ttrlqkerfmastsddaaalqsfaakaditidaarmrlakekmivmhplprndelsttvd
adpraayfrqmrygmfmrmailwsvla

    Sequence, based on observed residues (ATOM records): (download) 
    >6jl4F (F:)
mlelppvaslkgksitsaeqfsradiyalihlasamqrkidagevlnllqgrimtplffe
dssrtfssfcaamirlggsvvnfkveassinkgetladtirtldsysdvlvmrhprqdai
eealsvaqhpilnagngagehptqalldtltihselgsvdgitialigdlkmgrtvhsll
kllvrnfsikcvflvapdalqmpqdvleplqheiatkgviihrthaltdevmqksdvlyt
trlqkerfsddaaalqsfaakaditidaarmrlakekmivmhplprndelsttvdadpra
ayfrqmrygmfmrmailwsvla