PDB entry 6jd8

View 6jd8 on RCSB PDB site
Description: Structure of a proline specific mutant of human cathepsin L
Class: hydrolase
Keywords: protease, proline-specific, engineered, HYDROLASE
Deposited on 2019-01-31, released 2020-02-05
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-02-05, with a file datestamp of 2020-01-31.
Experiment type: XRAY
Resolution: 1.46 Å
R-factor: N/A
AEROSPACI score: 0.49 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cathepsin L1
    Species: Homo sapiens [TaxId:9606]
    Gene: CTSL, CTSL1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P07711 (44-359)
      • expression tag (43)
      • engineered mutation (164)
      • engineered mutation (208)
      • engineered mutation (300)
      • engineered mutation (303)
      • engineered mutation (353)
    Domains in SCOPe 2.08: d6jd8a1, d6jd8a2
  • Heterogens: GOL, EOH, PEG, EDO, PGE, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6jd8A (A:)
mhhhhhhssglvprgsgmketaaakferqhmdspdlgtddddkmtltfdhsleaqwtkwk
amhnrlygmneegwrravweknmkmielhnqeyregkhsftmamnafgdmtseefrqvmn
gfqnrkprkgkvfqeplfyeaprsvdwrekgyvtpvknqgqcgsswafsatgalegqmfr
ktgrlislseqnlvdcsgpqgnegcnggymdyafqyvqdnggldseesypyeateescky
npkysvandtgfvdipkqekalmkavatvgpisvaidaghesflfykegiyfepdcssed
ldhavlvvgygfestesdnnkywlvknswgeewgmggyvkmakdrrnhcgiaslasyptv

    Sequence, based on observed residues (ATOM records): (download) 
    >6jd8A (A:)
mtltfdhsleaqwtkwkamhnrlygmneegwrravweknmkmielhnqeyregkhsftma
mnafgdmtseefrqvmngfqkprkgkvfqeplfyeaprsvdwrekgyvtpvknqgqcgss
wafsatgalegqmfrktgrlislseqnlvdcsgpqgnegcnggymdyafqyvqdngglds
eesypyeateesckynpkysvandtgfvdipkqekalmkavatvgpisvaidaghesflf
ykegiyfepdcssedldhavlvvgygfestednnkywlvknswgeewgmggyvkmakdrr
nhcgiaslasyptv