PDB entry 6j63

View 6j63 on RCSB PDB site
Description: Crystal structure of Arabidopsis thaliana HPPD complexed with NTBC
Class: oxidoreductase
Keywords: 4-hydroxyphenylpyruvate dioxygenase, nitisinone, type I tyrosinemia, drug discovery, OXIDOREDUCTASE
Deposited on 2019-01-13, released 2019-02-06
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-03-20, with a file datestamp of 2019-03-15.
Experiment type: XRAY
Resolution: 2.62 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 4-hydroxyphenylpyruvate dioxygenase
    Species: Arabidopsis thaliana [TaxId:3702]
    Gene: HPD
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6j63a1, d6j63a2
  • Chain 'B':
    Compound: 4-hydroxyphenylpyruvate dioxygenase
    Species: Arabidopsis thaliana [TaxId:3702]
    Gene: HPD
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6j63b1, d6j63b2
  • Chain 'C':
    Compound: 4-hydroxyphenylpyruvate dioxygenase
    Species: Arabidopsis thaliana [TaxId:3702]
    Gene: HPD
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6j63c1, d6j63c2
  • Chain 'D':
    Compound: 4-hydroxyphenylpyruvate dioxygenase
    Species: Arabidopsis thaliana [TaxId:3702]
    Gene: HPD
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6j63d1, d6j63d2
  • Heterogens: FE, NTD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6j63A (A:)
mghqnaavsenqnhddgaasspgfklvgfskfvrknpksdkfkvkrfhhiefwcgdatnv
arrfswglgmrfsaksdlstgnmvhasylltsgdlrflftapyspslsageikptttasi
psfdhgscrsffsshglgvravaievedaesafsisvangaipssppivlneavtiaevk
lygdvvlryvsykaedtekseflpgfervedassfpldygirrldhavgnvpelgpalty
vagftgfhqfaeftaddvgtaesglnsavlasndemvllpinepvhgtkrksqiqtyleh
negaglqhlalmsedifrtlremrkrssiggfdfmpsppptyyqnlkkrvgdvlsddqik
eceelgilvdrddqgtllqiftkplgdrptifieiiqrvgcmmkdeegkayqsggcggfg
kgnfselfksieeyektleakqlvg

    Sequence, based on observed residues (ATOM records): (download) 
    >6j63A (A:)
skfvrknpksdkfkvkrfhhiefwcgdatnvarrfswglgmrfsaksdlstgnmvhasyl
ltsgdlrflftapyspsltttasipsfdhgscrsffsshglgvravaievedaesafsis
vangaipssppivlneavtiaevklygdvvlryvsykeflpgfervedpldygirrldha
vgnvpelgpaltyvagftgfhqfaefsglnsavlasndemvllpinepvrksqiqtyleh
negaglqhlalmsedifrtlremrkrssiggfdfmpsppptyyqnlkkrvgdvlsddqik
eceelgilvdrddqgtllqiftkplgdrptifieiiqrvgcmmyqsggcggfgkgnfsel
fksieey

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6j63B (B:)
mghqnaavsenqnhddgaasspgfklvgfskfvrknpksdkfkvkrfhhiefwcgdatnv
arrfswglgmrfsaksdlstgnmvhasylltsgdlrflftapyspslsageikptttasi
psfdhgscrsffsshglgvravaievedaesafsisvangaipssppivlneavtiaevk
lygdvvlryvsykaedtekseflpgfervedassfpldygirrldhavgnvpelgpalty
vagftgfhqfaeftaddvgtaesglnsavlasndemvllpinepvhgtkrksqiqtyleh
negaglqhlalmsedifrtlremrkrssiggfdfmpsppptyyqnlkkrvgdvlsddqik
eceelgilvdrddqgtllqiftkplgdrptifieiiqrvgcmmkdeegkayqsggcggfg
kgnfselfksieeyektleakqlvg

    Sequence, based on observed residues (ATOM records): (download) 
    >6j63B (B:)
skfvrknpksdkfkvkrfhhiefwcgdatnvarrfswglgmrfsaksdlstgnmvhasyl
ltsgdlrflftapyspsltttasipsfdhgscrsffsshglgvravaievedaesafsis
vangaipssppivlneavtiaevklygdvvlryvsykeflpgfervedfpldygirrldh
avgnvpelgpaltyvagftgfhqfaefsglnsavlasndemvllpinepvhgrksqiqty
lehnegaglqhlalmsedifrtlremrkrssiggfdfmpsppptyyqnlkkrvgdvlsdd
qikeceelgilvdrddqgtllqiftkplgdrptifieiiqrvgcmmyqsggcggfgkgnf
selfksieey

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6j63C (C:)
mghqnaavsenqnhddgaasspgfklvgfskfvrknpksdkfkvkrfhhiefwcgdatnv
arrfswglgmrfsaksdlstgnmvhasylltsgdlrflftapyspslsageikptttasi
psfdhgscrsffsshglgvravaievedaesafsisvangaipssppivlneavtiaevk
lygdvvlryvsykaedtekseflpgfervedassfpldygirrldhavgnvpelgpalty
vagftgfhqfaeftaddvgtaesglnsavlasndemvllpinepvhgtkrksqiqtyleh
negaglqhlalmsedifrtlremrkrssiggfdfmpsppptyyqnlkkrvgdvlsddqik
eceelgilvdrddqgtllqiftkplgdrptifieiiqrvgcmmkdeegkayqsggcggfg
kgnfselfksieeyektleakqlvg

    Sequence, based on observed residues (ATOM records): (download) 
    >6j63C (C:)
skfvrknpksdkfkvkrfhhiefwcgdatnvarrfswglgmrfsaksdlstgnmvhasyl
ltsgdlrflftapyspslttasipsfdhgscrsffsshglgvravaievedaesafsisv
angaipssppivlneavtiaevklygdvvlryvsykeflpgfervedpldygirrldhav
gnvpelgpaltyvagftgfhqfaefglnsavlasndemvllpinepvhgrksqiqtyleh
negaglqhlalmsedifrtlremrkrssiggfdfmpsppptyyqnlkkrvgdvlsddqik
eceelgilvdrddqgtllqiftkplgdrptifieiiqrvgcmqsggcggfgkgnfselfk
sieey

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6j63D (D:)
mghqnaavsenqnhddgaasspgfklvgfskfvrknpksdkfkvkrfhhiefwcgdatnv
arrfswglgmrfsaksdlstgnmvhasylltsgdlrflftapyspslsageikptttasi
psfdhgscrsffsshglgvravaievedaesafsisvangaipssppivlneavtiaevk
lygdvvlryvsykaedtekseflpgfervedassfpldygirrldhavgnvpelgpalty
vagftgfhqfaeftaddvgtaesglnsavlasndemvllpinepvhgtkrksqiqtyleh
negaglqhlalmsedifrtlremrkrssiggfdfmpsppptyyqnlkkrvgdvlsddqik
eceelgilvdrddqgtllqiftkplgdrptifieiiqrvgcmmkdeegkayqsggcggfg
kgnfselfksieeyektleakqlvg

    Sequence, based on observed residues (ATOM records): (download) 
    >6j63D (D:)
skfvrknpksdkfkvkrfhhiefwcgdatnvarrfswglgmrfsaksdlstgnmvhasyl
ltsgdlrflftapyspsltttasipsfdhgscrsffsshglgvravaievedaesafsis
vangaipssppivlneavtiaevklygdvvlryvsykeflpgfervedfpldygirrldh
avgnvpelgpaltyvagftgfhqfaefsglnsavlasndemvllpinepvhgrksqiqty
lehnegaglqhlalmsedifrtlremrkrssiggfdfmpsppptyyqnlkkrvgdvlsdd
qikeceelgilvdrddqgtllqiftkplgdrptifieiiqrvgcmmyqsggcggfgkgnf
selfksieey