PDB entry 6i07

View 6i07 on RCSB PDB site
Description: Crystal structure of EpCAM in complex with scFv
Class: immune system
Keywords: IMMUNE SYSTEM, single chain Fv, scFv, EpCAM
Deposited on 2018-10-25, released 2019-03-13
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-03-11, with a file datestamp of 2020-03-06.
Experiment type: XRAY
Resolution: 2.35 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: single chain fv
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6I07 (0-End)
    Domains in SCOPe 2.08: d6i07a1, d6i07a2
  • Chain 'B':
    Compound: single chain fv
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6I07 (0-End)
    Domains in SCOPe 2.08: d6i07b1, d6i07b2
  • Chain 'C':
    Compound: Epithelial cell adhesion molecule
    Species: Homo sapiens [TaxId:9606]
    Gene: EPCAM, GA733-2, M1S2, M4S1, MIC18, TACSTD1, TROP1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P16422 (1-End)
      • engineered mutation (50)
      • engineered mutation (87)
      • engineered mutation (174)
  • Chain 'D':
    Compound: Epithelial cell adhesion molecule
    Species: Homo sapiens [TaxId:9606]
    Gene: EPCAM, GA733-2, M1S2, M4S1, MIC18, TACSTD1, TROP1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P16422 (1-End)
      • engineered mutation (50)
      • engineered mutation (87)
      • engineered mutation (174)
  • Heterogens: GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6i07A (A:)
divmtqsplslpvtpgepasiscrstksllhsdgitylywylqkpgqspqlliyqlsnla
sgvpdrfsssgsgtdftlkisrveaedegvyycaqnleiprtfgcgtkleikrtggggsg
gggsggggsggggsqvqlvqsgaevkkpgesvkisckasgytftnygmnwvrqqpgqclk
wmgwintytgestyaddfkgrfafsldtsastaylqlsslrsedtavyfcarfaikgdyw
gqgtlvtvssgggggshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6i07A (A:)
divmtqsplslpvtpgepasiscrstksllhsdgitylywylqkpgqspqlliyqlsnla
sgvpdrfsssgsgtdftlkisrveaedegvyycaqnleiprtfgcgtkleiksqvqlvqs
gaevkkpgesvkisckasgytftnygmnwvrqqpgqclkwmgwintytgestyaddfkgr
fafsldtsastaylqlsslrsedtavyfcarfaikgdywgqgtlvtvs

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6i07B (B:)
divmtqsplslpvtpgepasiscrstksllhsdgitylywylqkpgqspqlliyqlsnla
sgvpdrfsssgsgtdftlkisrveaedegvyycaqnleiprtfgcgtkleikrtggggsg
gggsggggsggggsqvqlvqsgaevkkpgesvkisckasgytftnygmnwvrqqpgqclk
wmgwintytgestyaddfkgrfafsldtsastaylqlsslrsedtavyfcarfaikgdyw
gqgtlvtvssgggggshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >6i07B (B:)
divmtqsplslpvtpgepasiscrstksllhsdgitylywylqkpgqspqlliyqlsnla
sgvpdrfsssgsgtdftlkisrveaedegvyycaqnleiprtfgcgtkleiqvqlvqsga
evkkpgesvkisckasgytftnygmnwvrqqpgqclkwmgwintytgestyaddfkgrfa
fsldtsastaylqlsslrsedtavyfcarfaikgdywgqgtlvtvs

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.