PDB entry 6gwf

View 6gwf on RCSB PDB site
Description: Alpha-galactosidase mutant D387A from Thermotoga maritima in complex with intact cyclohexene-based carbasugar mimic of galactose with 2,4-dinitro leaving group
Class: hydrolase
Keywords: glycoside hydrolase, galactosidase, carbohydrate processing enzyme, inhibitor, HYDROLASE
Deposited on 2018-06-24, released 2018-08-22
The last revision prior to the SCOPe 2.07 freeze date was dated 2018-08-22, with a file datestamp of 2018-08-17.
Experiment type: XRAY
Resolution: 1.72 Å
R-factor: N/A
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: alpha-galactosidase
    Species: Thermotoga maritima MSB8 [TaxId:243274]
    Gene: galA, TM_1192, Tmari_1199
    Database cross-references and differences (RAF-indexed):
    • Uniprot G4FEF4 (23-End)
      • expression tag (13-22)
      • engineered mutation (409)
    Domains in SCOPe 2.07: d6gwfa1, d6gwfa2, d6gwfa3
  • Heterogens: FEQ, SO4, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6gwfA (A:)
mgsshhhhhhssglvprgshmasmeifgktfregrfvlkeknftvefavekihlgwkisg
rvkgspgrlevlrtkapekvlvnnwqswgpcrvvdafsfkppeidpnwrytasvvpdvle
rnlqsdyfvaeegkvygflsskiahpffavedgelvayleyfdvefddfvpleplvvled
pntplllekyaelvgmennarvpkhtptgwcswyhyfldltweetlknlklaknfpfevf
qiddayekdigdwlvtrgdfpsveemakviaengfipgiwtapfsvsetsdvfnehpdwv
vkengepkmayrnwnkkiyaldlskdevlnwlfdlfsslrkmgyryfkidflfagavpge
rkknitpiqafrkgietirkavgedsfilgcgspllpavgcvdgmrigpatapfwgehie
dngapaarwalrnaitryfmhdrfwlndpdclilreektdltqkekelysytcgvldnmi
iesddlslvrdhgkkvlketlellggrprvqnimsedlryeivssgtlsgnvkivvdlns
reyhlekegksslkkrvvkredgrnfyfyeegere

    Sequence, based on observed residues (ATOM records): (download) 
    >6gwfA (A:)
lvprgshmasmeifgktfregrfvlkeknftvefavekihlgwkisgrvkgspgrlevlr
tkapekvlvnnwqswgpcrvvdafsfkppeidpnwrytasvvpdvlernlqsdyfvaeeg
kvygflsskiahpffavedgelvayleyfdvefddfvpleplvvledpntplllekyael
vgmennarvpkhtptgwcswyhyfldltweetlknlklaknfpfevfqiddayekdigdw
lvtrgdfpsveemakviaengfipgiwtapfsvsetsdvfnehpdwvvkengepkmayrn
wnkkiyaldlskdevlnwlfdlfsslrkmgyryfkidflfagavpgerkknitpiqafrk
gietirkavgedsfilgcgspllpavgcvdgmrigpatapfwgehiedngapaarwalrn
aitryfmhdrfwlndpdclilreektdltqkekelysytcgvldnmiiesddlslvrdhg
kkvlketlellggrprvqnimsedlryeivssgtlsgnvkivvdlnsreyhleke