PDB entry 6eqs

View 6eqs on RCSB PDB site
Description: Human Sirt5 in complex with stalled peptidylimidate intermediate of inhibitory compound 29
Class: signaling protein
Keywords: Hydrolase, PTM, inhibitor, SIGNALING PROTEIN
Deposited on 2017-10-15, released 2017-11-01
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-22, with a file datestamp of 2017-11-17.
Experiment type: XRAY
Resolution: 1.32 Å
R-factor: N/A
AEROSPACI score: 0.57 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: NAD-dependent protein deacylase sirtuin-5, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: SIRT5, SIR2L5
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6eqsa_
  • Chain 'B':
    Compound: NAD-dependent protein deacylase sirtuin-5, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: SIRT5, SIR2L5
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6eqsb_
  • Chain 'C':
    Compound: NAD-dependent protein deacylase sirtuin-5, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: SIRT5, SIR2L5
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9NXA8 (6-274)
      • expression tag (1-5)
    Domains in SCOPe 2.08: d6eqsc1, d6eqsc2
  • Chain 'D':
    Compound: NAD-dependent protein deacylase sirtuin-5, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: SIRT5, SIR2L5
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9NXA8 (6-274)
      • expression tag (0-5)
    Domains in SCOPe 2.08: d6eqsd1, d6eqsd2
  • Heterogens: ZN, BV8, EDO, BU2, DMS, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6eqsA (A:)
gidpftarpsssmadfrkffakakhiviisgagvsaesgvptfrgaggywrkwqaqdlat
plafahnpsrvwefyhyrrevmgskepnaghraiaecetrlgkqgrrvvvitqnidelhr
kagtknlleihgslfktrctscgvvaenykspicpalsgkgapepgtqdasipveklprc
eeagcggllrphvvwfgenldpaileevdrelahcdlclvvgtssvvypaamfapqvaar
gvpvaefntettpatnrfrfhfqgpcgttlpeala

    Sequence, based on observed residues (ATOM records): (download) 
    >6eqsA (A:)
arpsssmadfrkffakakhiviisgagvsaesgvptfrgaggywrkwqaqdlatplafah
npsrvwefyhyrrevmgskepnaghraiaecetrlgkqgrrvvvitqnidelhrkagtkn
lleihgslfktrctscgvvaenykspicpalsgkgapepgtqdasipveklprceeagcg
gllrphvvwfgenldpaileevdrelahcdlclvvgtssvvypaamfapqvaargvpvae
fntettpatnrfrfhfqgpcgttlpeala

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6eqsB (B:)
gidpftarpsssmadfrkffakakhiviisgagvsaesgvptfrgaggywrkwqaqdlat
plafahnpsrvwefyhyrrevmgskepnaghraiaecetrlgkqgrrvvvitqnidelhr
kagtknlleihgslfktrctscgvvaenykspicpalsgkgapepgtqdasipveklprc
eeagcggllrphvvwfgenldpaileevdrelahcdlclvvgtssvvypaamfapqvaar
gvpvaefntettpatnrfrfhfqgpcgttlpeala

    Sequence, based on observed residues (ATOM records): (download) 
    >6eqsB (B:)
rpsssmadfrkffakakhiviisgagvsaesgvptfrgaggywrkwqaqdlatplafahn
psrvwefyhyrrevmgskepnaghraiaecetrlgkqgrrvvvitqnidelhrkagtknl
leihgslfktrctscgvvaenykspicpalsgkgapepgtqdasipveklprceeagcgg
llrphvvwfgenldpaileevdrelahcdlclvvgtssvvypaamfapqvaargvpvaef
ntettpatnrfrfhfqgpcgttlpeala

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6eqsC (C:)
gidpftarpsssmadfrkffakakhiviisgagvsaesgvptfrgaggywrkwqaqdlat
plafahnpsrvwefyhyrrevmgskepnaghraiaecetrlgkqgrrvvvitqnidelhr
kagtknlleihgslfktrctscgvvaenykspicpalsgkgapepgtqdasipveklprc
eeagcggllrphvvwfgenldpaileevdrelahcdlclvvgtssvvypaamfapqvaar
gvpvaefntettpatnrfrfhfqgpcgttlpeala

    Sequence, based on observed residues (ATOM records): (download) 
    >6eqsC (C:)
idpftarpsssmadfrkffakakhiviisgagvsaesgvptfrgaggywrkwqaqdlatp
lafahnpsrvwefyhyrrevmgskepnaghraiaecetrlgkqgrrvvvitqnidelhrk
agtknlleihgslfktrctscgvvaenykspicpalsgkgapepgtqdasipveklprce
eagcggllrphvvwfgenldpaileevdrelahcdlclvvgtssvvypaamfapqvaarg
vpvaefntettpatnrfrfhfqgpcgttlpeala

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >6eqsD (D:)
gidpftarpsssmadfrkffakakhiviisgagvsaesgvptfrgaggywrkwqaqdlat
plafahnpsrvwefyhyrrevmgskepnaghraiaecetrlgkqgrrvvvitqnidelhr
kagtknlleihgslfktrctscgvvaenykspicpalsgkgapepgtqdasipveklprc
eeagcggllrphvvwfgenldpaileevdrelahcdlclvvgtssvvypaamfapqvaar
gvpvaefntettpatnrfrfhfqgpcgttlpeala