PDB entry 6dyz

View 6dyz on RCSB PDB site
Description: Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with (3R,4S)-1-((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4-((prop-2-yn-1-ylthio)methyl)pyrrolidin-3-ol
Class: transferase
Keywords: MTAP enzyme, cancer, phosphorylase, TRANSFERASE
Deposited on 2018-07-02, released 2019-03-20
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-04, with a file datestamp of 2019-11-29.
Experiment type: XRAY
Resolution: 1.62 Å
R-factor: N/A
AEROSPACI score: 0.43 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: S-methyl-5'-thioadenosine phosphorylase
    Species: Homo sapiens [TaxId:9606]
    Gene: MTAP, MSAP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d6dyza_
  • Heterogens: CL, PO4, EDO, OS2, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6dyzA (A:)
mhhhhhhenlyfqsmasgttttavkigiiggtglddpeilegrtekyvdtpfgkpsdali
lgkiknvdcvllarhgrqhtimpskvnyqaniwalkeegcthvivttacgslreeiqpgd
iviidqfidrttmrpqsfydgshscargvchipmaepfcpktrevlietakklglrchsk
gtmvtiegprfssraesfmfrtwgadvinmttvpevvlakeagicyasiamatdydcwke
heeavsvdrvlktlkenankakslllttipqigstewsetlhnlknmaqfsvllprh

    Sequence, based on observed residues (ATOM records): (download) 
    >6dyzA (A:)
avkigiiggtglddpeilegrtekyvdtpfgkpsdalilgkiknvdcvllarhgrqhtim
pskvnyqaniwalkeegcthvivttacgslreeiqpgdiviidqfidrttmrpqsfydgs
hscargvchipmaepfcpktrevlietakklglrchskgtmvtiegprfssraesfmfrt
wgadvinmttvpevvlakeagicyasiamatdydcwkeheeavsvdrvlktlkenankak
slllttipqigstewsetlhnlknmaqfsvllp