PDB entry 6czn

View 6czn on RCSB PDB site
Description: Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with Z2OHTPE and a glucocorticoid receptor-interacting protein 1 NR box II peptide
Class: nuclear protein
Keywords: Estrogen Agonist, Breast Cancer, Nuclear Hormone Receptor, NUCLEAR PROTEIN
Deposited on 2018-04-09, released 2019-03-20
The last revision prior to the SCOPe 2.07 freeze date was dated 2019-03-20, with a file datestamp of 2019-03-15.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372
      • engineered mutation (239)
    Domains in SCOPe 2.07: d6czna_
  • Chain 'B':
    Compound: Estrogen receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ESR1, ESR, NR3A1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03372
      • engineered mutation (239)
    Domains in SCOPe 2.07: d6cznb_
  • Chain 'C':
    Compound: GRIP peptide
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6CZN
  • Chain 'D':
    Compound: GRIP peptide
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 6CZN
  • Heterogens: FNJ, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6cznA (A:)
ikrskknslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhm
inwakrvpgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkc
vegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihr
vldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvpls
dlllemldahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >6cznA (A:)
lsltadqmvsalldaeppilysseasmmglltnladrelvhminwakrvpgfvdltdqvh
llecawleilmiglvwrsmehpgkllfapnllldrnkegmveifdmllatssrfrmmnlq
geefvclksiillnsgvytfsleekdhihrvldkitdtlihlmakagltlqqqhqrlaql
llilshirhmsnkgmehlylsdlllemldahr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6cznB (B:)
ikrskknslalsltadqmvsalldaeppilyseydptrpfseasmmglltnladrelvhm
inwakrvpgfvdltlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkc
vegmveifdmllatssrfrmmnlqgeefvclksiillnsgvytflsstlksleekdhihr
vldkitdtlihlmakagltlqqqhqrlaqlllilshirhmsnkgmehlysmkcknvvpls
dlllemldahrlhapts

    Sequence, based on observed residues (ATOM records): (download) 
    >6cznB (B:)
lalsltadqmvsalldaeppilyseyfseasmmglltnladrelvhminwakrvpgfvdl
tlhdqvhllecawleilmiglvwrsmehpgkllfapnllldrnqgkcvegmveifdmlla
tssrfrmmnlqgeefvclksiillnsgvytkdhihrvldkitdtlihlmakagltlqqqh
qrlaqlllilshirhmsnkgmehlysmkplsdlllemldahr

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    No sequence available.