PDB entry 6b2n

View 6b2n on RCSB PDB site
Description: Crystal structure of TEM-1 beta-lactamase mutant M182N
Class: hydrolase
Keywords: Antibiotic resistance, beta-lactamase, HYDROLASE
Deposited on 2017-09-20, released 2018-01-17
The last revision prior to the SCOPe 2.07 freeze date was dated 2018-01-17, with a file datestamp of 2018-01-12.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Beta-lactamase TEM
    Species: Escherichia coli [TaxId:562]
    Gene: bla, blaT-3, blaT-4, blaT-5, blaT-6
    Database cross-references and differences (RAF-indexed):
    • Uniprot P62593 (0-262)
      • engineered mutation (156)
    Domains in SCOPe 2.07: d6b2na_
  • Chain 'B':
    Compound: Beta-lactamase TEM
    Species: Escherichia coli [TaxId:562]
    Gene: bla, blaT-3, blaT-4, blaT-5, blaT-6
    Database cross-references and differences (RAF-indexed):
    • Uniprot P62593 (0-262)
      • engineered mutation (156)
    Domains in SCOPe 2.07: d6b2nb_
  • Chain 'C':
    Compound: Beta-lactamase TEM
    Species: Escherichia coli [TaxId:562]
    Gene: bla, blaT-3, blaT-4, blaT-5, blaT-6
    Database cross-references and differences (RAF-indexed):
    • Uniprot P62593 (0-262)
      • engineered mutation (156)
    Domains in SCOPe 2.07: d6b2nc_
  • Chain 'D':
    Compound: Beta-lactamase TEM
    Species: Escherichia coli [TaxId:562]
    Gene: bla, blaT-3, blaT-4, blaT-5, blaT-6
    Database cross-references and differences (RAF-indexed):
    • Uniprot P62593 (0-262)
      • engineered mutation (156)
    Domains in SCOPe 2.07: d6b2nd_
  • Heterogens: SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >6b2nA (A:)
hpetlvkvkdaedqlgarvgyieldlnsgkilesfrpeerfpmmstfkvllcgavlsrvd
agqeqlgrrihysqndlveyspvtekhltdgmtvrelcsaaitmsdntaanlllttiggp
keltaflhnmgdhvtrldrwepelneaipnderdttnpaamattlrklltgelltlasrq
qlidwmeadkvagpllrsalpagwfiadksgagergsrgiiaalgpdgkpsrivviyttg
sqatmdernrqiaeigaslikhw

    Sequence, based on observed residues (ATOM records): (download) 
    >6b2nA (A:)
hpetlvkvkdaedqlgarvgyieldlsgkilesfrpeerfpmmstfkvllcgavlsrvda
gqeqlgrrihysqndlveyspvtekhltdgmtvrelcsaaitmsdntaanlllttiggpk
eltaflhnmgdhvtrldrwepelneaipnderdttnpaamattlrklltgelltlasrqq
lidwmeadkvagpllrsalpagwfiadksagergsrgiiaalgpdgkpsrivviyttgsq
atmdernrqiaeigalikhw

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >6b2nB (B:)
hpetlvkvkdaedqlgarvgyieldlnsgkilesfrpeerfpmmstfkvllcgavlsrvd
agqeqlgrrihysqndlveyspvtekhltdgmtvrelcsaaitmsdntaanlllttiggp
keltaflhnmgdhvtrldrwepelneaipnderdttnpaamattlrklltgelltlasrq
qlidwmeadkvagpllrsalpagwfiadksgagergsrgiiaalgpdgkpsrivviyttg
sqatmdernrqiaeigaslikhw

    Sequence, based on observed residues (ATOM records): (download) 
    >6b2nB (B:)
hpetlvkvkdaedqlgarvgyiellnskilesfrpeerfpmmstfkvllcgavlsrvdag
qeqlgrrihysqndlveyspvtekhltdgmtvrelcsaaitmsdntaanlllttiggpke
ltaflhnmgdhvtrldrwepelneaipnderdttnpaamattlrklltgelltlasrqql
idwmeadkvallrsalpagwfiadksgagergsrgiiaalpdgkpsrivviyttgstmde
rrqiaeigaslikhw

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >6b2nC (C:)
hpetlvkvkdaedqlgarvgyieldlnsgkilesfrpeerfpmmstfkvllcgavlsrvd
agqeqlgrrihysqndlveyspvtekhltdgmtvrelcsaaitmsdntaanlllttiggp
keltaflhnmgdhvtrldrwepelneaipnderdttnpaamattlrklltgelltlasrq
qlidwmeadkvagpllrsalpagwfiadksgagergsrgiiaalgpdgkpsrivviyttg
sqatmdernrqiaeigaslikhw

    Sequence, based on observed residues (ATOM records): (download) 
    >6b2nC (C:)
hpetlvkvkdaedqlarvgyieldlnsgkilesfrpeerfpmmstfkvllcgavlsrvda
gqeqlgrrihysqndlveyspvtekhltdgmtvrelcsaaitmsdntaanlllttiggpk
eltaflhnmgdhvtrldrwepelneaipnderdttnpaamattlrklltgelltlasrqq
lidwmeadkvlralpagwfiadksgagergsrgiiaalgpdgkpsrivviyttgsqatmd
ernrqiaeigaslikhw

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >6b2nD (D:)
hpetlvkvkdaedqlgarvgyieldlnsgkilesfrpeerfpmmstfkvllcgavlsrvd
agqeqlgrrihysqndlveyspvtekhltdgmtvrelcsaaitmsdntaanlllttiggp
keltaflhnmgdhvtrldrwepelneaipnderdttnpaamattlrklltgelltlasrq
qlidwmeadkvagpllrsalpagwfiadksgagergsrgiiaalgpdgkpsrivviyttg
sqatmdernrqiaeigaslikhw

    Sequence, based on observed residues (ATOM records): (download) 
    >6b2nD (D:)
hpetlvkvkdaedqlgarvgyieldlnsgkilesfrpeerfpmmstfkvllcgavlsrvd
agqeqlgrrihysqndlveyspvtekhltdgmtvrelcsaaitmsdntaanlllttiggp
keltaflhnmgdhvtrldrwepelneaipnderdttnpaamattlrklltgelltlasrq
qlidwmeadkvagpllrsalpawfiadksgagergsrgiiaalgpdgkpsrivviyttgs
qatmdernrqieigaslikhw