PDB entry 5x8m

View 5x8m on RCSB PDB site
Description: PD-L1 in complex with durvalumab
Class: immune system
Keywords: complex, antibody, IMMUNE SYSTEM
Deposited on 2017-03-03, released 2017-08-16
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-08-16, with a file datestamp of 2017-08-11.
Experiment type: XRAY
Resolution: 2.66 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Programmed cell death 1 ligand 1
    Species: Homo sapiens [TaxId:9606]
    Gene: CD274, B7H1, PDCD1L1, PDCD1LG1, PDL1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9NZQ7 (0-End)
      • engineered mutation (29)
    Domains in SCOPe 2.07: d5x8ma_
  • Chain 'B':
    Compound: durvalumab heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5X8M (0-End)
  • Chain 'C':
    Compound: durvalumab light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 5X8M
    Domains in SCOPe 2.07: d5x8mc1, d5x8mc2
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5x8mA (A:)
aftvtvpkdlyvveygsnmtieckfpvekeldlaalivywemedkniiqfvhgeedlkvq
hssyrqrarllkdqlslgnaalqitdvklqdagvyrcmisyggadykritvkvnapyhhh
hhh

    Sequence, based on observed residues (ATOM records): (download) 
    >5x8mA (A:)
aftvtvpkdlyvveygsnmtieckfpvekeldlaalivywemedkniiqfvhgeedlkvq
hssyrqrarllkdqlslgnaalqitdvklqdagvyrcmisyggadykritvkvnap

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5x8mC (C:)
eivltqspgtlslspgeratlscrasqrvsssylawyqqkpgqaprlliydassratgip
drfsgsgsgtdftltisrlepedfavyycqqygslpwtfgqgtkveikrtvaapsvfifp
psdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstl
tlskadyekhkvyacevthqglsspvtksfnrgec

    Sequence, based on observed residues (ATOM records): (download) 
    >5x8mC (C:)
ivltqspgtlslspgeratlscrasqrvsssylawyqqkpgqaprlliydassratgipd
rfsgsgsgtdftltisrlepedfavyycqqygslpwtfgqgtkveikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrge