PDB entry 5wct

View 5wct on RCSB PDB site
Description: Crystal structure of the influenza virus PA endonuclease in complex with inhibitor 6c (SRI-29775)
Class: hydrolase/hydrolase inhibitor
Keywords: nuclease, transcription, cap-snatching, virus, HYDROLASE, hydrolase-hydrolase inhibitor complex
Deposited on 2017-07-01, released 2018-01-03
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-11, with a file datestamp of 2019-12-06.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Polymerase acidic protein
    Species: Influenza A virus [TaxId:641501]
    Gene: PA
    Database cross-references and differences (RAF-indexed):
    • Uniprot C3W5S0 (0-49)
      • linker (50-52)
    • Uniprot C3W5S0 (53-176)
    Domains in SCOPe 2.08: d5wcta_
  • Heterogens: GY4, MN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5wctA (A:)
medfvrqcfnpmivelaekamkeygedpkietnkfaaicthlevcfmysdggskhrfeii
egrdrimawtvvnsicnttgvekpkflpdlydykenrfieigvtrrevhiyylekankik
sekthihifsftgeematkadytldeesrariktrlftirqemasrslwdsfrqseraaa
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    Sequence, based on observed residues (ATOM records): (download) 
    >5wctA (A:)
medfvrqcfnpmivelaekamkeygedpkietnkfaaicthlevcfmysdggskhrfeii
egrdrimawtvvnsicnttgvekpkflpdlydykenrfieigvtrrevhiyylekankik
sekthihifsftgeematkadytldeesrariktrlftirqemasrslwdsfrqser