PDB entry 5vlr

View 5vlr on RCSB PDB site
Description: crystal structure of pi3k delta in complex with a trifluoro-ethyl-pyrazol-pyrolotriazine inhibitor
Class: transferase/transferase regulator
Keywords: LIPID KINASE, INHIBITOR, PI3K DELTA, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX, TRANSFERASE-TRANSFERASE REGULATOR complex
Deposited on 2017-04-26, released 2017-06-07
The last revision prior to the SCOPe 2.06 freeze date was dated 2017-06-07, with a file datestamp of 2017-06-02.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
    Species: Homo sapiens [TaxId:9606]
    Gene: Pik3cd
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Phosphatidylinositol 3-kinase regulatory subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: PIK3R1, GRB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P27986 (0-169)
      • engineered mutation (38)
      • engineered mutation (88)
      • engineered mutation (98)
      • engineered mutation (108)
    Domains in SCOPe 2.06: d5vlrb_
  • Heterogens: 9EM, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >5vlrB (B:)
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ikifeeqcqtqeryskeyiekfkregneteiqrimhnyeklksriseivdsrrrleedlk
kqaaeyreidkrmnsikpdliqlrktrdqylmwltqkgvrqkklnewlgn