PDB entry 5uip

View 5uip on RCSB PDB site
Description: structure of DHFR with bound DAP, p-ABG and NADP
Class: oxidoreductase
Keywords: DHFR, NADP, 2, 4 diaminopyridine, N-(4aminobenzoyl)-L-glutamate, OXIDOREDUCTASE
Deposited on 2017-01-14, released 2017-11-22
The last revision prior to the SCOPe 2.06 freeze date was dated 2017-11-22, with a file datestamp of 2017-11-17.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: N/A
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dihydrofolate reductase
    Species: Escherichia coli [TaxId:562]
    Gene: folA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0ABQ4 (1-158)
      • expression tag (0)
      • engineered mutation (151)
    Domains in SCOPe 2.06: d5uipa1, d5uipa2
  • Chain 'B':
    Compound: dihydrofolate reductase
    Species: Escherichia coli [TaxId:562]
    Gene: folA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0ABQ4 (1-158)
      • expression tag (0)
      • engineered mutation (151)
    Domains in SCOPe 2.06: d5uipb1, d5uipb2
  • Heterogens: 8DM, LG3, NAP, NA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5uipA (A:)
gisliaalavdrvigmenampwnlpadlawfkrntlnkpvimgrhtwesigrplpgrkni
ilssqpgtddrvtwvksvdeaiaacgdvpeimvigggrvyeqflpkaqklylthidaeve
gdthfpdyepddwesvfsefhdadaqnshsysfeilerrgggg

    Sequence, based on observed residues (ATOM records): (download) 
    >5uipA (A:)
gisliaalavdrvigmenampwnlpadlawfkrntlnkpvimgrhtwesigrplpgrkni
ilssqpgtddrvtwvksvdeaiaacgdvpeimvigggrvyeqflpkaqklylthidaeve
gdthfpdyepddwesvfsefhdadaqnshsysfeilerr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5uipB (B:)
gisliaalavdrvigmenampwnlpadlawfkrntlnkpvimgrhtwesigrplpgrkni
ilssqpgtddrvtwvksvdeaiaacgdvpeimvigggrvyeqflpkaqklylthidaeve
gdthfpdyepddwesvfsefhdadaqnshsysfeilerrgggg

    Sequence, based on observed residues (ATOM records): (download) 
    >5uipB (B:)
gisliaalavdrvigmenampwnlpadlawfkrntlnkpvimgrhtwesigrplpgrkni
ilssqpgtddrvtwvksvdeaiaacgdvpeimvigggrvyeqflpkaqklylthidaeve
gdthfpdyepddwesvfsefhdadaqnshsysfeilerr