PDB entry 5ubt

View 5ubt on RCSB PDB site
Description: crystal structure of pi3k delta in complex with a 7-(3-(piperazin-1-yl)phenyl)pyrrolo[2,1-f][1,2,4] triazin-4-amine deriviatine
Class: transferase/transferase regulator
Keywords: LIPID KINASE, INHIBITOR, PI3K DELTA, TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX, TRANSFERASE-TRANSFERASE REGULATOR complex
Deposited on 2016-12-21, released 2017-02-08
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-02-22, with a file datestamp of 2017-02-17.
Experiment type: XRAY
Resolution: 2.83 Å
R-factor: N/A
AEROSPACI score: 0.15 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
    Species: Homo sapiens [TaxId:9606]
    Gene: Pik3cd
    Database cross-references and differences (RAF-indexed):
  • Chain 'B':
    Compound: Phosphatidylinositol 3-kinase regulatory subunit alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: PIK3R1, GRB1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P27986 (Start-167)
      • engineered mutation (37)
      • engineered mutation (87)
      • engineered mutation (97)
      • engineered mutation (107)
    Domains in SCOPe 2.07: d5ubtb_
  • Heterogens: 85S, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5ubtB (B:)
qqdqvvkednieavgkklheyntqfqeksreydrlyedytrtsqeiqmkrtaieafneti
kifeeqcqtqeryskeyiekfkregneteiqrimhnyeklksriseivdsrrrleedlkk
qaaeyreidkrmnsikpdliqlrktrdqylmwltqkgvrqkklnewlg

    Sequence, based on observed residues (ATOM records): (download) 
    >5ubtB (B:)
vkednieavgkklheyntqfqeksreydrlyedytrtsqeiqmkrtaieafnetikifee
qcqtqeryskeyiekfkregneteiqrimhnyeklksriseivdsrrrleedlkkqaaey
reidkrmnsikpdliqlrktrdqylmwltqkgvrqkklnewlg