PDB entry 5tx6

View 5tx6 on RCSB PDB site
Description: Structure of TGF-beta2 derivative with deletion of residues 52-71 and 10 single amino acid mutations (mmTGF-beta2-7M)
Class: cytokine
Keywords: Growth Factor, CYTOKINE
Deposited on 2016-11-15, released 2017-03-01
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-09-27, with a file datestamp of 2017-09-22.
Experiment type: XRAY
Resolution: 2.75 Å
R-factor: N/A
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Transforming growth factor beta-2
    Species: Mus musculus [TaxId:10090]
    Gene: TGFB2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P27090 (1-92)
      • engineered mutation (25-26)
      • engineered mutation (54)
      • engineered mutation (57)
      • engineered mutation (69)
      • engineered mutation (72)
      • engineered mutation (74-75)
      • engineered mutation (78)
    Domains in SCOPe 2.07: d5tx6a_
  • Chain 'B':
    Compound: Transforming growth factor beta-2
    Species: Mus musculus [TaxId:10090]
    Gene: TGFB2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P27090 (1-92)
      • engineered mutation (25-26)
      • engineered mutation (51)
      • engineered mutation (54)
      • engineered mutation (57)
      • engineered mutation (69)
      • engineered mutation (72)
      • engineered mutation (74-75)
      • engineered mutation (78)
    Domains in SCOPe 2.07: d5tx6b_
  • Chain 'C':
    Compound: Transforming growth factor beta-2
    Species: Mus musculus [TaxId:10090]
    Gene: TGFB2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P27090 (1-92)
      • engineered mutation (25-26)
      • engineered mutation (57)
      • engineered mutation (69)
      • engineered mutation (72)
      • engineered mutation (74-75)
      • engineered mutation (78)
    Domains in SCOPe 2.07: d5tx6c_
  • Heterogens: CA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5tx6A (A:)
maldaaycfrnvqdncclrplyidfrkdlgwkwihepkgynanfcagacpyraskspscv
sqdlepltivyyvgrkpkveqlsnmivksckcs

    Sequence, based on observed residues (ATOM records): (download) 
    >5tx6A (A:)
aldaaycfrnvqdncclrplyidfrkdlgwkwihepkgynanfcagacpkspscvsqdle
pltivyyvgrkpkveqlsnmivksckcs

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5tx6B (B:)
maldaaycfrnvqdncclrplyidfrkdlgwkwihepkgynanfcagacpyraskspscv
sqdlepltivyyvgrkpkveqlsnmivksckcs

    Sequence, based on observed residues (ATOM records): (download) 
    >5tx6B (B:)
aldaaycfrnvqdncclrplyidfrkdlgwkwihepkgynanfcagacpyraskspscvs
qdlepltivyyvgrkpkveqlsnmivksckcs

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5tx6C (C:)
maldaaycfrnvqdncclrplyidfrkdlgwkwihepkgynanfcagacpyraskspscv
sqdlepltivyyvgrkpkveqlsnmivksckcs

    Sequence, based on observed residues (ATOM records): (download) 
    >5tx6C (C:)
aldaaycfrnvqdncclrplyidfrkdlgwkwihepkgynanfcascvsqdlepltivyy
vgrkpkveqlsnmivksckcs