PDB entry 5tp9

View 5tp9 on RCSB PDB site
Description: Structure of the human GluN1/GluN2A LBD in complex with compound 2 (GNE9178)
Class: transport protein
Keywords: NMDA receptor, glutamate, glycine, calcium channel, membrane, TRANSPORT PROTEIN
Deposited on 2016-10-20, released 2016-11-30
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-02-08, with a file datestamp of 2017-02-03.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Glutamate receptor ionotropic, NMDA 2A
    Species: Homo sapiens [TaxId:9606]
    Gene: GRIN2A, NMDAR2A
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q12879 (Start-140)
      • linker (141-142)
    • Uniprot Q12879 (143-End)
    Domains in SCOPe 2.08: d5tp9a_
  • Chain 'B':
    Compound: Glutamate receptor ionotropic, NMDA 1
    Species: Homo sapiens [TaxId:9606]
    Gene: Grin1, Nmdar1
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q05586 (2-152)
      • linker (153-154)
    • Uniprot Q05586 (155-End)
    Domains in SCOPe 2.08: d5tp9b_
  • Heterogens: ACT, GLU, 7H0, CA, GLY, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5tp9A (A:)
gspddnhlsivtleeapfvivedidpltetcvrntvpcrkfvkinnstnegmnvkkcckg
fcidilkklsrtvkftydlylvtngkhgkkvnnvwngmigevvyqravmavgsltineer
sevvdfsvpfvetgisvmvsrgtqvtglsdkkfqrphdysppfrfgtvpngsternirnn
ypymhqymtkfnqkgvedalvslktgkldafiydaavlnykagrdegcklvtigsgyifa
ttgygialqkgspwkrqidlallqfvgdgemeeletlwltgichn

    Sequence, based on observed residues (ATOM records): (download) 
    >5tp9A (A:)
nhlsivtleeapfvivedidetcvrntvpcrkfvkinnstnegmnvkkcckgfcidilkk
lsrtvkftydlylvtngkhgkkvnnvwngmigevvyqravmavgsltineersevvdfsv
pfvetgisvmvsrgtqvtglsdkkfqrphdysppfrfgtvpngsternirnnypymhqym
tkfnqkgvedalvslktgkldafiydaavlnykagrdegcklvtigsgyifattgygial
qkgspwkrqidlallqfvgdgemeeletlwltgic

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5tp9B (B:)
gsmstrlkivtihqepfvyvkptlsdgtckeeftvngdpvkkvictgpndtspgsprhtv
pqccygfcidlliklartmnftyevhlvadgkfgtqervnnsnkkewngmmgellsgqad
mivapltinneraqyiefskpfkyqgltilvkkgtritgindprlrnpsdkfiyatvkqs
svdiyfrrqvelstmyrhmekhnyesaaeaiqavrdnklhafiwdsavlefeasqkcdlv
ttgelffrsgfgigmrkdspwkqnvslsilkshengfmedldktwvryqecds

    Sequence, based on observed residues (ATOM records): (download) 
    >5tp9B (B:)
mstrlkivtihqepfvyvkptlsdgtckeeftvngdpvkkvictgpndtspgsprhtvpq
ccygfcidlliklartmnftyevhlvadgkfgtqervnkkewngmmgellsgqadmivap
ltinneraqyiefskpfkyqgltilvkkgtritgindprlrnpsdkfiyatvkqssvdiy
frrqvelstmyrhmekhnyesaaeaiqavrdnklhafiwdsavlefeasqkcdlvttgel
ffrsgfgigmrkdspwkqnvslsilkshengfmedldktwvryq