PDB entry 5svf

View 5svf on RCSB PDB site
Description: IDH1 R132H in complex with IDH125
Class: oxidoreductase
Keywords: Isocitrate dehydrogenase, Rossmann fold, NADPH, inhibitor, OXIDOREDUCTASE
Deposited on 2016-08-05, released 2017-02-08
The last revision prior to the SCOPe 2.06 freeze date was dated 2017-02-08, with a file datestamp of 2017-02-03.
Experiment type: XRAY
Resolution: 2.34 Å
R-factor: N/A
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: isocitrate dehydrogenase [nadp] cytoplasmic
    Species: Homo sapiens [TaxId:9606]
    Gene: IDH1, PICD
    Database cross-references and differences (RAF-indexed):
    • Uniprot O75874
      • engineered mutation (134)
    Domains in SCOPe 2.06: d5svfa_
  • Chain 'B':
    Compound: isocitrate dehydrogenase [nadp] cytoplasmic
    Species: Homo sapiens [TaxId:9606]
    Gene: IDH1, PICD
    Database cross-references and differences (RAF-indexed):
    • Uniprot O75874
      • engineered mutation (134)
    Domains in SCOPe 2.06: d5svfb_
  • Chain 'C':
    Compound: isocitrate dehydrogenase [nadp] cytoplasmic
    Species: Homo sapiens [TaxId:9606]
    Gene: IDH1, PICD
    Database cross-references and differences (RAF-indexed):
    • Uniprot O75874 (Start-416)
      • engineered mutation (134)
    Domains in SCOPe 2.06: d5svfc_
  • Chain 'D':
    Compound: isocitrate dehydrogenase [nadp] cytoplasmic
    Species: Homo sapiens [TaxId:9606]
    Gene: IDH1, PICD
    Database cross-references and differences (RAF-indexed):
    • Uniprot O75874
      • engineered mutation (134)
    Domains in SCOPe 2.06: d5svfd_
  • Heterogens: NDP, 70P, FLC, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5svfA (A:)
gpgmskkisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvt
kdaaeaikkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaiickni
prlvsgwvkpiiighhaygdqyratdfvvpgpgkveitytpsdgtqkvtylvhnfeeggg
vamgmynqdksiedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyks
qfeaqkiwyehrliddmvaqamkseggfiwacknydgdvqsdsvaqgygslgmmtsvlvc
pdgktveaeaahgtvtrhyrmyqkgqetstnpiasifawtrglahrakldnnkelaffan
aleevsietieagfmtkdlaacikglpnvqrsdylntfefmdklgenlkiklaqakl

    Sequence, based on observed residues (ATOM records): (download) 
    >5svfA (A:)
kisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvtkdaaea
ikkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaiickniprlvsg
wvkpiiighhaatdfvvpgpgkveitytpsdgtqkvtylvhnfeegggvamgmynqdksi
edfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyksqfeaqkiwyehr
liddmvaqamkseggfiwacknqsdsvaqgygslgmmtsvlvcpdgktveaeaahgtvtr
hyrmyqkgqetstnpiasifawtrglahrakldnnkelaffanaleevsietieagfmtk
dlaacikglpnvqrsdylntfefmdklgenlkiklaqa

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5svfB (B:)
gpgmskkisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvt
kdaaeaikkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaiickni
prlvsgwvkpiiighhaygdqyratdfvvpgpgkveitytpsdgtqkvtylvhnfeeggg
vamgmynqdksiedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyks
qfeaqkiwyehrliddmvaqamkseggfiwacknydgdvqsdsvaqgygslgmmtsvlvc
pdgktveaeaahgtvtrhyrmyqkgqetstnpiasifawtrglahrakldnnkelaffan
aleevsietieagfmtkdlaacikglpnvqrsdylntfefmdklgenlkiklaqakl

    Sequence, based on observed residues (ATOM records): (download) 
    >5svfB (B:)
kkisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvtkdaae
aikkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaiickniprlvs
gwvkpiiighhratdfvvpgpgkveitytpsdgtqkvtylvhnfeegggvamgmynqdks
iedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyksqfeaqkiwyeh
rliddmvaqamkseggfiwacksdsvaqgygslgmmtsvlvcpdgktveaeaahgtvtrh
yrmyqkgqetstnpiasifawtrglahrakldnnkelaffanaleevsietieagfmtkd
laacikglpnvqrsdylntfefmdklgenlkiklaqa

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5svfC (C:)
gpgmskkisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvt
kdaaeaikkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaiickni
prlvsgwvkpiiighhaygdqyratdfvvpgpgkveitytpsdgtqkvtylvhnfeeggg
vamgmynqdksiedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyks
qfeaqkiwyehrliddmvaqamkseggfiwacknydgdvqsdsvaqgygslgmmtsvlvc
pdgktveaeaahgtvtrhyrmyqkgqetstnpiasifawtrglahrakldnnkelaffan
aleevsietieagfmtkdlaacikglpnvqrsdylntfefmdklgenlkiklaqakl

    Sequence, based on observed residues (ATOM records): (download) 
    >5svfC (C:)
kisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvtkdaaea
ikkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaiickniprlvsg
wvkpiiighharatdfvvpgpgkveitytpsdgtqkvtylvhnfeegggvamgmynqdks
iedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyksqfeaqkiwyeh
rliddmvaqamkseggfiwacksdsvaqgygslgmmtsvlvcpdgktveaeaahgtvtrh
yrmyqkgqetstnpiasifawtrglahrakldnnkelaffanaleevsietieagfmtkd
laacikglpnvqrsdylntfefmdklgenlkiklaqakl

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5svfD (D:)
gpgmskkisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvt
kdaaeaikkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaiickni
prlvsgwvkpiiighhaygdqyratdfvvpgpgkveitytpsdgtqkvtylvhnfeeggg
vamgmynqdksiedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyks
qfeaqkiwyehrliddmvaqamkseggfiwacknydgdvqsdsvaqgygslgmmtsvlvc
pdgktveaeaahgtvtrhyrmyqkgqetstnpiasifawtrglahrakldnnkelaffan
aleevsietieagfmtkdlaacikglpnvqrsdylntfefmdklgenlkiklaqakl

    Sequence, based on observed residues (ATOM records): (download) 
    >5svfD (D:)
kisggsvvemqgdemtriiwelikeklifpyveldlhsydlgienrdatndqvtkdaaea
ikkhnvgvkcatitpdekrveefklkqmwkspngtirnilggtvfreaiickniprlvsg
wvkpiiighhaygdqyratdfvvpgpgkveitytpsdgtqkvtylvhnfeegggvamgmy
nqdksiedfahssfqmalskgwplylstkntilkkydgrfkdifqeiydkqyksqfeaqk
iwyehrliddmvaqamkseggfiwacknqsdsvaqgygslgmmtsvlvcpdgktveaeaa
hgtvtrhyrmyqkgqetstnpiasifawtrglahrakldnnkelaffanaleevsietie
agfmtkdlaacikglpnvqrsdylntfefmdklgenlkikla