PDB entry 5nvm

View 5nvm on RCSB PDB site
Description: Crystal structure of the human 4EHP-GIGYF2 complex lacking the auxiliary sequences
Class: translation
Keywords: translational regulation, cap-binding protein, 4EHP-binding protein, GRB10-interacting GYF protein 2, translation
Deposited on 2017-05-04, released 2017-07-26
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-07-26, with a file datestamp of 2017-07-21.
Experiment type: XRAY
Resolution: 2 Å
R-factor: N/A
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: eukaryotic translation initiation factor 4e type 2
    Species: Homo sapiens [TaxId:9606]
    Gene: EIF4E2, EIF4EL3
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60573 (6-End)
      • expression tag (0-5)
    Domains in SCOPe 2.07: d5nvma1, d5nvma2
  • Chain 'B':
    Compound: GRB10-interacting GYF protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: GIGYF2, KIAA0642, PERQ2, TNRC15
    Database cross-references and differences (RAF-indexed):
  • Chain 'C':
    Compound: eukaryotic translation initiation factor 4e type 2
    Species: Homo sapiens [TaxId:9606]
    Gene: EIF4E2, EIF4EL3
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60573 (6-End)
      • expression tag (5)
    Domains in SCOPe 2.07: d5nvmc1, d5nvmc2
  • Chain 'D':
    Compound: GRB10-interacting GYF protein 2
    Species: Homo sapiens [TaxId:9606]
    Gene: GIGYF2, KIAA0642, PERQ2, TNRC15
    Database cross-references and differences (RAF-indexed):
  • Heterogens: PO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5nvmA (A:)
gphmleaehplqynytfwysrrtpgrptssqsyeqnikqigtfasveqfwrfyshmvrpg
dltghsdfhlfkegikpmweddanknggkwiirlrkglasrcwenlilamlgeqfmvgee
icgavvsvrfqediisiwnktasdqattarirdtlrrvlnlppntimeykthtdsikmpg
rlgpqrllf

    Sequence, based on observed residues (ATOM records): (download) 
    >5nvmA (A:)
gphmleaehplqynytfwysrrtpgrptssqsyeqnikqigtfasveqfwrfyshmvrpg
dltghsdfhlfkegikpmweddanknggkwiirlrkglasrcwenlilamlgeqfmvgee
icgavvsvrfqediisiwnktasdqattarirdtlrrvlnlppntimeykthtdsi

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5nvmC (C:)
gphmleaehplqynytfwysrrtpgrptssqsyeqnikqigtfasveqfwrfyshmvrpg
dltghsdfhlfkegikpmweddanknggkwiirlrkglasrcwenlilamlgeqfmvgee
icgavvsvrfqediisiwnktasdqattarirdtlrrvlnlppntimeykthtdsikmpg
rlgpqrllf

    Sequence, based on observed residues (ATOM records): (download) 
    >5nvmC (C:)
eaehplqynytfwysrrqnikqigtfasveqfwrfyshmvrpgdltghsdfhlfkegikp
mweddanknggkwiirlrkglasrcwenlilamlgeqfmvgeeicgavvsvrfqediisi
wnktasdqattarirdtlrrvlnlppntimeykthtd

  • Chain 'D':
    No sequence available.