PDB entry 5nrn

View 5nrn on RCSB PDB site
Description: Mtb TMK crystal structure in complex with compound 3
Class: transferase
Keywords: Thymidylate kinase, Nucleotide Binding, inhibitor, Transferase
Deposited on 2017-04-25, released 2018-08-08
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-08-08, with a file datestamp of 2018-08-03.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: thymidylate kinase
    Species: MYCOBACTERIUM TUBERCULOSIS H37RV [TaxId:83332]
    Gene: tmk, Rv3247c
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5nrna_
  • Chain 'B':
    Compound: thymidylate kinase
    Species: MYCOBACTERIUM TUBERCULOSIS H37RV [TaxId:83332]
    Gene: tmk, Rv3247c
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d5nrnb_
  • Heterogens: 95W, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5nrnA (A:)
mliaiegvdgagkrtlveklsgafraagrsvatlafprygqsvaadiaaealhgehgdla
ssvyamatlfaldragavhtiqglcrgydvvildryvasnaaysaarlhenaagkaaawv
qriefarlglpkpdwqvllavsaelagersrgraqrdpgrardnyerdaelqqrtgavya
elaaqgwggrwlvvgadvdpgrlaatlappdvps

    Sequence, based on observed residues (ATOM records): (download) 
    >5nrnA (A:)
mliaiegvdgagkrtlveklsgafraagrsvatlafprygqsvaadiaaealhgehgdla
ssvyamatlfaldragavhtiqglcrgydvvildryvasnaaysaarlhenaagkaaawv
qriefarlglpkpdwqvllavsadaelqqrtgavyaelaaqgwggrwlvvgadvdpgrla
atlappd

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5nrnB (B:)
mliaiegvdgagkrtlveklsgafraagrsvatlafprygqsvaadiaaealhgehgdla
ssvyamatlfaldragavhtiqglcrgydvvildryvasnaaysaarlhenaagkaaawv
qriefarlglpkpdwqvllavsaelagersrgraqrdpgrardnyerdaelqqrtgavya
elaaqgwggrwlvvgadvdpgrlaatlappdvps

    Sequence, based on observed residues (ATOM records): (download) 
    >5nrnB (B:)
mliaiegvdgagkrtlveklsgafraagrsvatlafprygqsvaadiaaealhgehgdla
ssvyamatlfaldragavhtiqglcrgydvvildryvasnaaysaarlhenaagkaaawv
qriefarlglpkpdwqvllavsaelagersrgraqrdpgrardnyerdaelqqrtgavya
elaaqgwggrwlvvgadvdpgrlaatlappd