PDB entry 5nba

View 5nba on RCSB PDB site
Description: Complement factor D in complex with the inhibitor (2S,4R)-4-Fluoro-pyrrolidine-1,2-dicarboxylic acid 1-[(1-carbamoyl-1H-indol-3-yl)-amide] 2-[(3-trifluoromethoxy-phenyl)-amide]
Class: hydrolase
Keywords: hydrolase
Deposited on 2017-03-01, released 2017-06-28
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-07-26, with a file datestamp of 2017-07-21.
Experiment type: XRAY
Resolution: 1.87 Å
R-factor: N/A
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: complement factor d
    Species: Homo sapiens [TaxId:9606]
    Gene: CFD, DF, PFD
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00746 (0-227)
      • expression tag (228-229)
    Domains in SCOPe 2.07: d5nbaa1, d5nbaa2
  • Heterogens: 8S5, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5nbaA (A:)
ilggreaeaharpymasvqlngahlcggvlvaeqwvlsaahcledaadgkvqvllgahsl
sqpepskrlydvlravphpdsqpdtidhdllllqlsekatlgpavrplpwqrvdrdvapg
tlcdvagwgivnhagrrpdslqhvllpvldratcnrrthhdgaiterlmcaesnrrdsck
gdsggplvcggvlegvvtsgsrvcgnrkkpgiytrvasyaawidsvlasa

    Sequence, based on observed residues (ATOM records): (download) 
    >5nbaA (A:)
ilggreaeaharpymasvqlngahlcggvlvaeqwvlsaahclekvqvllgahslsqpep
skrlydvlravphpdsqpdtidhdllllqlsekatlgpavrplpwqrvdrdvapgtlcdv
agwgivnhagrrpdslqhvllpvldratcnrrthhdgaiterlmcaesnrrdsckgdsgg
plvcggvlegvvtsgsrvcgnrkkpgiytrvasyaawidsvlasa