PDB entry 5ksh

View 5ksh on RCSB PDB site
Description: Crystal structure of penicillin-binding protein 2 from Neisseria gonorrhoeae containing an A501T mutation associated with cephalosporin resistance
Class: biosynthetic protein
Keywords: biosynthetic protein, class b transpeptidase, peptidoglycan synthesis
Deposited on 2016-07-08, released 2017-03-01
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-25, with a file datestamp of 2019-12-20.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Penicillin-binding protein 2
    Species: NEISSERIA GONORRHOEAE [TaxId:485]
    Gene: penA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08149
      • engineered mutation (459)
      • engineered mutation (462)
      • engineered mutation (468)
      • engineered mutation (474)
      • engineered mutation (509)
    Domains in SCOPe 2.08: d5ksha1, d5ksha2
  • Chain 'B':
    Compound: Penicillin-binding protein 2
    Species: NEISSERIA GONORRHOEAE [TaxId:485]
    Gene: penA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08149
      • engineered mutation (459)
      • engineered mutation (462)
      • engineered mutation (468)
      • engineered mutation (474)
      • engineered mutation (509)
    Domains in SCOPe 2.08: d5kshb1, d5kshb2
  • Heterogens: GOL, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5kshA (A:)
gsarglylqtvtynflkeqgdnrivrtqalpatrgtvsdrngavlalsapteslfavpkd
mkempsaaqlerlselvdvpvdvlrnkleqkgksfiwikrqldpkvaeevkalglenfvf
ekelkrhypmgnlfahvigftdidgkgqeglelsledslygedgaevvlrdrqgnivdsl
dsprnkapqngkdiilsldqriqtlayeelnkaveyhqakagtvvvldartgeilalant
paydpnrpgradseqrrnravtdmiepgsaikpfviakaldagktdlnerlntqpykigp
spvrdthvypsldvrgimqkssnvgtsklsarfgaeemydfyhelgigvrmhsgfpgeta
gllrnwrrwrpieqatmsfgyglqlsllqlaraytalthdgvllplsfekqavapqgkri
fkestarevrnlmvsvtepggtgtagavdgfdvgaktgttrklvngryvdnkhvgtfigf
apaknprvivavtideptahgyyggvvagspfkkimggslnilgisptkpltaaavktps

    Sequence, based on observed residues (ATOM records): (download) 
    >5kshA (A:)
tynflkeqgdnrivrtqalpatrgtvsdrngavlalsaptelkrhypmgnlfahvigftd
idgkgqeglelsledslygedgaevvlrdrqgnivdsldsprnkapqngkdiilsldqri
qtlayeelnkaveyhqakagtvvvldartgeilalantpaydpnrpgradseqrrnravt
dmiepgsaikpfviakaldagktdlnerlntqpykigpspvrdthvypsldvrgimqkss
nvgtsklsarfgaeemydfyhelgigvrmhsgfpgetagllrnwrrwrpieqatmsfgyg
lqlsllqlaraytalthdgvllplsfekqavapqgkrifkestarevrnlmvsvtepggt
gtagavdgfdvgaktgttrklvngryvdnkhvgtfigfapaknprvivavtideptahgy
yggvvagspfkkimggslnilgisptkplt

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5kshB (B:)
gsarglylqtvtynflkeqgdnrivrtqalpatrgtvsdrngavlalsapteslfavpkd
mkempsaaqlerlselvdvpvdvlrnkleqkgksfiwikrqldpkvaeevkalglenfvf
ekelkrhypmgnlfahvigftdidgkgqeglelsledslygedgaevvlrdrqgnivdsl
dsprnkapqngkdiilsldqriqtlayeelnkaveyhqakagtvvvldartgeilalant
paydpnrpgradseqrrnravtdmiepgsaikpfviakaldagktdlnerlntqpykigp
spvrdthvypsldvrgimqkssnvgtsklsarfgaeemydfyhelgigvrmhsgfpgeta
gllrnwrrwrpieqatmsfgyglqlsllqlaraytalthdgvllplsfekqavapqgkri
fkestarevrnlmvsvtepggtgtagavdgfdvgaktgttrklvngryvdnkhvgtfigf
apaknprvivavtideptahgyyggvvagspfkkimggslnilgisptkpltaaavktps

    Sequence, based on observed residues (ATOM records): (download) 
    >5kshB (B:)
ivrtqalpatrgtvsdrngavlalsapteelkrhypmgnlfahvigftdidgkgqeglel
sledslygedgaevvlrdnivdsldsprnkapqngkdiilsldqriqtlayeelnkavey
hqakagtvvvldartgeilalantpaydpnrpgradseqrrnravtdmiepgsaikpfvi
akaldagktdlnerlntqpykigpspvrdthvypsldvrgimqkssnvgtsklsarfgae
emydfyhelgigvrmhsgfpgetagllrnwrrwrpieqatmsfgyglqlsllqlarayta
lthdgvllplsfekqavapqgkrifkestarevrnlmvsvtepggtgtagavdgfdvgak
tgttrklvngryvdnkhvgtfigfapaknprvivavtideptahgyyggvvagspfkkim
ggslnilgisptkplt