PDB entry 5j8r

View 5j8r on RCSB PDB site
Description: Crystal Structure of the Catalytic Domain of Human Protein Tyrosine Phosphatase non-receptor Type 12 - K61R mutant
Class: hydrolase
Keywords: cancer, tyrosine phosphorylation, HYDROLASE
Deposited on 2016-04-08, released 2016-04-27
The last revision prior to the SCOPe 2.07 freeze date was dated 2016-05-18, with a file datestamp of 2016-05-13.
Experiment type: XRAY
Resolution: 2.04 Å
R-factor: N/A
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein phosphatase non-receptor type 12
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN12
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q05209
      • engineered mutation (66)
    Domains in SCOPe 2.07: d5j8ra_
  • Chain 'B':
    Compound: Tyrosine-protein phosphatase non-receptor type 12
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN12
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q05209
      • engineered mutation (66)
    Domains in SCOPe 2.07: d5j8rb_
  • Chain 'C':
    Compound: Tyrosine-protein phosphatase non-receptor type 12
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN12
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q05209 (6-End)
      • engineered mutation (66)
    Domains in SCOPe 2.07: d5j8rc_
  • Chain 'D':
    Compound: Tyrosine-protein phosphatase non-receptor type 12
    Species: Homo sapiens [TaxId:9606]
    Gene: PTPN12
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q05209 (6-End)
      • engineered mutation (66)
    Domains in SCOPe 2.07: d5j8rd_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5j8rA (A:)
hhhhhhmeqveilrkfiqrvqamkspdhngednfardfmrlrrlstkyrtekiyptatge
keenvkrnrykdilpfdhsrvkltlktpsqdsdyinanfikgvygpkayvatqgplantv
idfwrmiweynvviivmacrefemgrkkcerywplygedpitfapfkiscedeqartdyf
irtlllefqnesrrlyqfhyvnwpdhdvpssfdsildmislmrkyqehedvpicihcsag
cgrtgaicaidytwnllkagkipeefnvfnliqemrtqrhsavqtkeqyelvhraiaqlf
ekqlqlyeihg

    Sequence, based on observed residues (ATOM records): (download) 
    >5j8rA (A:)
eqveilrkfiqrvqamkspdhngednfardfmrlrrlstkyrtekiyptatgekeenvkr
nrykdilpfdhsrvkltlktpsqdsdyinanfikgvygpkayvatqgplantvidfwrmi
weynvviivmacrefemgrkkcerywplygedpitfapfkiscedeqartdyfirtllle
fqnesrrlyqfhyvnwpdhdssfdsildmislmrkyqehedvpicihcsagcgrtgaica
idytwnllkagkipeefnvfnliqemrtqrhsavqtkeqyelvhraiaqlfekqlq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5j8rB (B:)
hhhhhhmeqveilrkfiqrvqamkspdhngednfardfmrlrrlstkyrtekiyptatge
keenvkrnrykdilpfdhsrvkltlktpsqdsdyinanfikgvygpkayvatqgplantv
idfwrmiweynvviivmacrefemgrkkcerywplygedpitfapfkiscedeqartdyf
irtlllefqnesrrlyqfhyvnwpdhdvpssfdsildmislmrkyqehedvpicihcsag
cgrtgaicaidytwnllkagkipeefnvfnliqemrtqrhsavqtkeqyelvhraiaqlf
ekqlqlyeihg

    Sequence, based on observed residues (ATOM records): (download) 
    >5j8rB (B:)
eqveilrkfiqrvqamkspdhngednfardfmrlrrlstkyrtekiyptatgekeenvkr
nrykdilpfdhsrvkltlktpsqdsdyinanfikgvygpkayvatqgplantvidfwrmi
weynvviivmacrefemgrkkcerywplygedpitfapfkiscedeqartdyfirtllle
fqnesrrlyqfhyvnwpdsfdsildmislmrkyqehedvpicihcsagcgrtgaicaidy
twnllkagkipeefnvfnliqemrtqrhsavqtkeqyelvhraiaqlfekqlq

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >5j8rC (C:)
hhhhhhmeqveilrkfiqrvqamkspdhngednfardfmrlrrlstkyrtekiyptatge
keenvkrnrykdilpfdhsrvkltlktpsqdsdyinanfikgvygpkayvatqgplantv
idfwrmiweynvviivmacrefemgrkkcerywplygedpitfapfkiscedeqartdyf
irtlllefqnesrrlyqfhyvnwpdhdvpssfdsildmislmrkyqehedvpicihcsag
cgrtgaicaidytwnllkagkipeefnvfnliqemrtqrhsavqtkeqyelvhraiaqlf
ekqlqlyeihg

    Sequence, based on observed residues (ATOM records): (download) 
    >5j8rC (C:)
meqveilrkfiqrvqamdnfardfmrlrrlstkyrtekiyptatgekeenvkrnrykdil
pfdhsrvkltlktpsqdsdyinanfikgvygpkayvatqgplantvidfwrmiweynvvi
ivmacrefemgrkkcerywplygedpitfapfkiscedeqartdyfirtlllefqnesrr
lyqfhyvnwpdhfdsildmislmrkyqehedvpicihcsagcgrtgaicaidytwnllka
gkipeefnvfnliqemrtqrhsavqtkeqyelvhraiaqlfekqlq

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5j8rD (D:)
hhhhhhmeqveilrkfiqrvqamkspdhngednfardfmrlrrlstkyrtekiyptatge
keenvkrnrykdilpfdhsrvkltlktpsqdsdyinanfikgvygpkayvatqgplantv
idfwrmiweynvviivmacrefemgrkkcerywplygedpitfapfkiscedeqartdyf
irtlllefqnesrrlyqfhyvnwpdhdvpssfdsildmislmrkyqehedvpicihcsag
cgrtgaicaidytwnllkagkipeefnvfnliqemrtqrhsavqtkeqyelvhraiaqlf
ekqlqlyeihg

    Sequence, based on observed residues (ATOM records): (download) 
    >5j8rD (D:)
meqveilrkfiqrvqamdnfardfmrlrrlstkyrtekiyptatgekeenvkrnrykdil
pfdhsrvkltltpsdsdyinanfikgvygpkayvatqgplantvidfwrmiweynvviiv
macrefemgrkkcerywplygedpitfapfkiscedeqartdyfirtlllefqnesrrly
qfhyvnwpdhfdsildmislmrkyqehedvpicihcsagcgrtgaicaidytwnllkagk
ipeefnvfnliqemrtqrhsavqtkeqyelvhraiaqlfekqlq