PDB entry 5icm

View 5icm on RCSB PDB site
Description: 17beta-hydroxysteroid dehydrogenase type 14 in complex with a non-steroidal inhibitor
Class: oxidoreductase
Keywords: hydroxysteroid dehydrogenase, inhibitor complex, oxidoreductase
Deposited on 2016-02-23, released 2016-07-13
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-06-29.
Experiment type: XRAY
Resolution: 1.68 Å
R-factor: N/A
AEROSPACI score: 0.49 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 17-beta-hydroxysteroid dehydrogenase 14
    Species: Homo sapiens [TaxId:9606]
    Gene: HSD17B14, DHRS10, SDR3, SDR47C1, UNQ502/PRO474
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9BPX1 (Start-271)
      • expression tag (272)
    Domains in SCOPe 2.08: d5icma1, d5icma2
  • Heterogens: NAD, NA, F45, GLC, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5icmA (A:)
ghmatgtryagkvvvvtgggrgigagivrafvnsgarvvicdkdesggraleqelpgavf
ilcdvtqeddvktlvsetirrfgrldcvvnnaghhpppqrpeetsaqgfrqllelnllgt
ytltklalpylrksqgnvinisslvgaigqaqavpyvatkgavtamtkalaldespygvr
vncispgniwtplweelaalmpdpratiregmlaqplgrmgqpaevgaaavflaseanfc
tgiellvtggaelgygckasrstpvdapdipsgs

    Sequence, based on observed residues (ATOM records): (download) 
    >5icmA (A:)
tryagkvvvvtgggrgigagivrafvnsgarvvicdkdesggraleqelpgavfilcdvt
qeddvktlvsetirrfgrldcvvnnaghhpppqrpeetsaqgfrqllelnllgtytltkl
alpylrksqgnvinisslvgaigqaqavpyvatkgavtamtkalaldespygvrvncisp
gniwtplweelaalmpdpratiregmlaqplgrmgqpaevgaaavflaseanfctgiell
vtggaelgygckpsg