PDB entry 5hvg

View 5hvg on RCSB PDB site
Description: Crystal Structure of Thrombin-activatable Fibrinolysis Inhibitor in Complex with an Inhibitory Nanobody (VHH-a204)
Class: hydrolase/hydrolase inhibitor
Keywords: procarboxypeptidase U, thrombin-activatable fibrinolysis inhibitor, TAFI, procarboxypeptidase R, plasma procarboxypeptidase B, nanobody, antibody fragment, protein complex, hydrolase/hydrolase inhibitor, hydrolase-hydrolase inhibitor complex
Deposited on 2016-01-28, released 2016-06-22
The last revision prior to the SCOPe 2.07 freeze date was dated 2016-08-31, with a file datestamp of 2016-08-24.
Experiment type: XRAY
Resolution: 3.05 Å
R-factor: N/A
AEROSPACI score: 0.13 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Carboxypeptidase B2
    Species: Homo sapiens [TaxId:9606]
    Gene: CPB2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q96IY4 (0-400)
      • engineered mutation (304)
      • engineered mutation (328)
      • engineered mutation (332)
      • engineered mutation (334)
  • Chain 'B':
    Compound: VHH-a204
    Species: VICUGNA PACOS [TaxId:30538]
    Database cross-references and differences (RAF-indexed):
    • PDB 5HVG (0-End)
    Domains in SCOPe 2.07: d5hvgb1, d5hvgb2
  • Chain 'C':
    Compound: Carboxypeptidase B2
    Species: Homo sapiens [TaxId:9606]
    Gene: CPB2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q96IY4 (Start-400)
      • engineered mutation (304)
      • engineered mutation (328)
      • engineered mutation (332)
      • engineered mutation (334)
  • Chain 'D':
    Compound: VHH-a204
    Species: VICUGNA PACOS [TaxId:30538]
    Database cross-references and differences (RAF-indexed):
    • PDB 5HVG
    Domains in SCOPe 2.07: d5hvgd1, d5hvgd2
  • Heterogens: NAG, BMA, MAN, ZN, ACT

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5hvgB (B:)
qvqlqesggglvqpggslrlscaasgsifsgnamgwyrqapgkqrelvaaitsggstdya
dsvkgrftisrdnakntvylqmnslkpedtavyychvdprpwgydvtdydywgqgtqvtv
sshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >5hvgB (B:)
qvqlqesggglvqpggslrlscaasgsifsgnamgwyrqapgkqrelvaaitsggstdya
dsvkgrftisrdnakntvylqmnslkpedtavyychvdprpwgydvtdydywgqgtqvtv
ss

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >5hvgD (D:)
qvqlqesggglvqpggslrlscaasgsifsgnamgwyrqapgkqrelvaaitsggstdya
dsvkgrftisrdnakntvylqmnslkpedtavyychvdprpwgydvtdydywgqgtqvtv
sshhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >5hvgD (D:)
vqlqesggglvqpggslrlscaasgsifsgnamgwyrqapgkqrelvaaitsggstdyad
svkgrftisrdnakntvylqmnslkpedtavyychvdprpwgydvtdydywgqgtqvtv