PDB entry 5eym

View 5eym on RCSB PDB site
Description: mek1 in complex with bi 847325
Class: transferase
Keywords: KINASE, Inhibitor, transferase
Deposited on 2015-11-25, released 2016-08-17
The last revision prior to the SCOPe 2.07 freeze date was dated 2016-10-19, with a file datestamp of 2016-10-14.
Experiment type: XRAY
Resolution: 2.7 Å
R-factor: N/A
AEROSPACI score: 0.18 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dual specificity mitogen-activated protein kinase kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: MAP2K1, MEK1, PRKMK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5eyma_
  • Chain 'B':
    Compound: Dual specificity mitogen-activated protein kinase kinase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: MAP2K1, MEK1, PRKMK1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d5eymb_
  • Heterogens: 5U5, CA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5eymA (A:)
kkleeleldeqqrkrleafltqkqkvgelkdddfekiselgagnggvvfkvshkpsglvm
arklihleikpairnqiirelqvlhecnspyivgfygafysdgeisicmehmdggsldqv
lkkagripeqilgkvsiavikgltylrekhkimhrdvkpsnilvnsrgeiklcdfgvsgq
lidsmansfvgtrsymsperlqgthysvqsdiwsmglslvemavgrypipppdakelelm
fgcqvegdaaetpprprtpgrplnkfgmdsrppmaifelldyivnepppklpsgvfslef
qdfvnkcliknpaeradlkqlmvhafikrsdaeevdfagwlcstiglnqpstpthaagv

    Sequence, based on observed residues (ATOM records): (download) 
    >5eymA (A:)
eldeqqrkrleafltqkqkvgelkdddfekiselgagvvfkvshkpsglvmarklihlei
kpairnqiirelqvlhecnspyivgfygafysdgeisicmehmdggsldqvlkkagripe
qilgkvsiavikgltylreimhrdvkpsnilvnsrgeiklcdfgvsgqlidsmtrsymsp
erlvqsdiwsmglslvemavgrypipppdakelelmfpmaifelldyivnepppklpsgv
fslefqdfvnkcliknpaeradlkqlmvhafikrsdaeevdfagwlcstigl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >5eymB (B:)
kkleeleldeqqrkrleafltqkqkvgelkdddfekiselgagnggvvfkvshkpsglvm
arklihleikpairnqiirelqvlhecnspyivgfygafysdgeisicmehmdggsldqv
lkkagripeqilgkvsiavikgltylrekhkimhrdvkpsnilvnsrgeiklcdfgvsgq
lidsmansfvgtrsymsperlqgthysvqsdiwsmglslvemavgrypipppdakelelm
fgcqvegdaaetpprprtpgrplnkfgmdsrppmaifelldyivnepppklpsgvfslef
qdfvnkcliknpaeradlkqlmvhafikrsdaeevdfagwlcstiglnqpstpthaagv

    Sequence, based on observed residues (ATOM records): (download) 
    >5eymB (B:)
eldeqqrkrleafltqkqkvgelkdddfekiselgagvvfkvshkpsglvmarklihlei
kpairnqiirelqvlhecnspyivgfygafysdgeisicmehmdggsldqvlkkagripe
qilgkvsiavikgltylreimhrdvkpsnilvnsrgeiklcdfgvsgqlidsmtrsymsp
erlvqsdiwsmglslvemavgrypipppdakelelmfpmaifelldyivnepppklpsgv
fslefqdfvnkcliknpaeradlkqlmvhafikrsdaeevdfagwlcstigl