PDB entry 5eap

View 5eap on RCSB PDB site
Description: Crystal structure of human WDR5 in complex with compound 9e
Class: Transcription/Transcription inhibitor
Keywords: WDR5, compound 9e, Structural Genomics, Structural Genomics Consortium, SGC, Transcription-Transcription inhibitor complex
Deposited on 2015-10-16, released 2015-11-04
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-05-23, with a file datestamp of 2018-05-18.
Experiment type: XRAY
Resolution: 1.73 Å
R-factor: N/A
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: WD repeat-containing protein 5
    Species: Homo sapiens [TaxId:9606]
    Gene: WDR5, BIG3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61964 (1-311)
      • expression tag (0)
    Domains in SCOPe 2.08: d5eapa1, d5eapa2
  • Heterogens: 5MO, GOL, CL, EDO, UNX, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5eapA (A:)
gtqskptpvkpnyalkftlaghtkavssvkfspngewlasssadklikiwgaydgkfekt
isghklgisdvawssdsnllvsasddktlkiwdvssgkclktlkghsnyvfccnfnpqsn
livsgsfdesvriwdvktgkclktlpahsdpvsavhfnrdgslivsssydglcriwdtas
gqclktlidddnppvsfvkfspngkyilaatldntlklwdyskgkclktytghknekyci
fanfsvtggkwivsgsednlvyiwnlqtkeivqklqghtdvvistachpteniiasaale
ndktiklwksdc

    Sequence, based on observed residues (ATOM records): (download) 
    >5eapA (A:)
gtqskptpvkpnyalkftlaghtkavssvkfspngewlasssadklikiwgaydgkfekt
isghklgisdvawssdsnllvsasddktlkiwdvssgkclktlkghsnyvfccnfnpqsn
livsgsfdesvriwdvktgkclktlpahsdpvsavhfnrdgslivsssydglcriwdtas
gqclktlidnppvsfvkfspngkyilaatldntlklwdyskgkclktytghknekycifa
nfsvtggkwivsgsednlvyiwnlqtkeivqklqghtdvvistachpteniiasaalend
ktiklwksdc