PDB entry 5bro

View 5bro on RCSB PDB site
Description: Crystal structure of modified HexB (modB)
Class: hydrolase
Keywords: Therapeutic enzyme, HYDROLASE
Deposited on 2015-06-01, released 2016-05-04
The last revision prior to the SCOPe 2.07 freeze date was dated 2016-05-04, with a file datestamp of 2016-04-29.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Beta-hexosaminidase subunit beta
    Species: Homo sapiens [TaxId:9606]
    Gene: HEXB, HCC7
    Database cross-references and differences (RAF-indexed):
    • Uniprot P07686
      • engineered mutation (269-272)
      • engineered mutation (409-410)
    Domains in SCOPe 2.07: d5broa1, d5broa2
  • Heterogens: GOL, FMT, NAG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >5broA (A:)
arapsvsakpgpalwplplsvkmtpnllhlapenfyishspnstagpsctlleeafrryh
gyifgfykwhhepaefqaktqvqqllvsitlqsecdafpnissdesytllvkepvavlka
nrvwgalrgletfsqlvyqdsygtftinestiidsprfshrgilidtsrhylpvkiilkt
ldamafnkfnvlhwhivddqsfpyqsitfpelsnkgsyslshvytpndvrmvieyarlrg
irvlpefdtpghtlswgkgqkdlltpcysgsepldsfgpinptlnttysflttffkeise
vfpdqfihlggdevefkcwesnpkiqdfmrqkgfgtdfkklesfyiqkvldiiatinkgs
ivwqevfddkaklapgtivevwkdsaypeelsrvtasgfpvilsapwylnrisygqdwrk
yykvepldfggtqkqkqlfiggeaclwgeyvdatnltprlwprasavgerlwsskdvrdm
ddaydrltrhrcrmvergiaaqplyagycnhenm

    Sequence, based on observed residues (ATOM records): (download) 
    >5broA (A:)
gpalwplplsvkmtpnllhlapenfyishspnstagpsctlleeafrryhgyifgfqakt
qvqqllvsitlqsecdafpnissdesytllvkepvavlkanrvwgalrgletfsqlvyqd
sygtftinestiidsprfshrgilidtsrhylpvkiilktldamafnkfnvlhwhivddq
sfpyqsitfpelsnkgsyslshvytpndvrmvieyarlrgirvlpefdtpghtlswgkgq
kdlltpcysgsepldsfgpinptlnttysflttffkeisevfpdqfihlggdevefkcwe
snpkiqdfmrqkgfgtdfkklesfyiqkvldiiatinkgsivwqevfddkaklapgtive
vwkdsaypeelsrvtasgfpvilsapwylnrisygqdwrkyykvepldfggtqkqkqlfi
ggeaclwgeyvdatnltprlwprasavgerlwsskdvrdmddaydrltrhrcrmvergia
aqplyagycn