PDB entry 4y46

View 4y46 on RCSB PDB site
Description: Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) inhibitors
Class: transferase/transferase inhibitor
Keywords: JNK, MAP kinase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2015-02-10, released 2015-05-06
The last revision prior to the SCOPe 2.08 freeze date was dated 2015-05-06, with a file datestamp of 2015-05-01.
Experiment type: XRAY
Resolution: 2.04 Å
R-factor: N/A
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Mitogen-activated protein kinase 10
    Species: Homo sapiens [TaxId:9606]
    Gene: MAPK10, JNK3, JNK3A, PRKM10, SAPK1B
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4y46a_
  • Heterogens: 4F2, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4y46A (A:)
mamskskvdnqfysvevgdstftvlkryqnlkpigsgaqgivcaaydavldrnvaikkls
rpfqnqthakrayrelvlmkcvnhkniisllnvftpqktleefqdvylvmelmdanlcqv
iqmeldhermsyllyqmlcgikhlhsagiihrdlkpsnivvksdctlkildfglartagt
sfmmtpyvvtryyrapevilgmgykenvdiwsvgcimgemvrhkilfpgrdyidqwnkvi
eqlgtpcpefmkklqptvrnyvenrpkyagltfpklfpdslfpadsehnklkasqardll
skmlvidpakrisvddalqhpyinvwydpaeveapppqiydkqlderehtieewkeliyk
evmnse

    Sequence, based on observed residues (ATOM records): (download) 
    >4y46A (A:)
dnqfysvevgdstftvlkryqnlkpigsgaqgivcaaydavldrnvaikklsrpfqnqth
akrayrelvlmkcvnhkniisllnvftpqktleefqdvylvmelmdanlcqviqmeldhe
rmsyllyqmlcgikhlhsagiihrdlkpsnivvksdctlkildfglartasfmmtpyvvt
ryyrapevilgmgykenvdiwsvgcimgemvrhkilfpgrdyidqwnkvieqlgtpcpef
mkklqptvrnyvenrpkyagltfpklfpdslfpadsehnklkasqardllskmlvidpak
risvddalqhpyinvwydqlderehtieewkeliykevmn