SCOPe 2.08: Domain d4y46a_: 4y46 A:

Lineage for d4y46a_ (4y46 A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein c-jun N-terminal kinase (jnk3s) [56137] (1 species)
   CMGC group; ERK/MAPK subfamily; serine/threonine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56138] (50 PDB entries)

8. Domain d4y46a_: 4y46 A: [272472]
   automated match to d2xrwa_
   complexed with 4f2

Details for d4y46a_

PDB Entry: 4y46, 2.04 Å

PDB Description: pyridopyrimidinone derivatives as potent and selective c-jun n- terminal kinase (jnk) inhibitors

PDB Compounds: (A:) Mitogen-activated protein kinase 10

SCOPe Domain Sequences for d4y46a_:

Sequence, based on SEQRES records:

>d4y46a_ d.144.1.7 (A:) c-jun N-terminal kinase (jnk3s) {Human (Homo sapiens) [TaxId: 9606]}
dnqfysvevgdstftvlkryqnlkpigsgaqgivcaaydavldrnvaikklsrpfqnqth
akrayrelvlmkcvnhkniisllnvftpqktleefqdvylvmelmdanlcqviqmeldhe
rmsyllyqmlcgikhlhsagiihrdlkpsnivvksdctlkildfglartagtsfmmtpyv
vtryyrapevilgmgykenvdiwsvgcimgemvrhkilfpgrdyidqwnkvieqlgtpcp
efmkklqptvrnyvenrpkyagltfpklfpdslfpadsehnklkasqardllskmlvidp
akrisvddalqhpyinvwydpaeveapppqiydkqlderehtieewkeliykevmn

Sequence, based on observed residues (ATOM records):

>d4y46a_ d.144.1.7 (A:) c-jun N-terminal kinase (jnk3s) {Human (Homo sapiens) [TaxId: 9606]}
dnqfysvevgdstftvlkryqnlkpigsgaqgivcaaydavldrnvaikklsrpfqnqth
akrayrelvlmkcvnhkniisllnvftpqktleefqdvylvmelmdanlcqviqmeldhe
rmsyllyqmlcgikhlhsagiihrdlkpsnivvksdctlkildfglartasfmmtpyvvt
ryyrapevilgmgykenvdiwsvgcimgemvrhkilfpgrdyidqwnkvieqlgtpcpef
mkklqptvrnyvenrpkyagltfpklfpdslfpadsehnklkasqardllskmlvidpak
risvddalqhpyinvwydqlderehtieewkeliykevmn

Timeline for d4y46a_:

• d4y46a_ first appeared in SCOPe 2.05
  
• d4y46a_ appears in SCOPe 2.07