PDB entry 4xfu

View 4xfu on RCSB PDB site
Description: Structure of IL-18 SER Mutant V
Class: cytokine
Keywords: cytokine, Interleukin-18, IL-18, surface entropy reduction, immune defense
Deposited on 2014-12-29, released 2015-06-10
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-09-20, with a file datestamp of 2017-09-15.
Experiment type: XRAY
Resolution: 2.85 Å
R-factor: N/A
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Interleukin-18
    Species: Homo sapiens [TaxId:9606]
    Gene: IL18, IGIF, IL1F4
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q14116 (0-End)
      • engineered mutation (56)
      • engineered mutation (66)
      • engineered mutation (68-70)
      • engineered mutation (104)
    Domains in SCOPe 2.07: d4xfua_
  • Chain 'B':
    Compound: Interleukin-18
    Species: Homo sapiens [TaxId:9606]
    Gene: IL18, IGIF, IL1F4
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q14116 (0-End)
      • engineered mutation (56)
      • engineered mutation (66)
      • engineered mutation (68-70)
      • engineered mutation (104)
    Domains in SCOPe 2.07: d4xfub_

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4xfuA (A:)
yfgklesklsvirnlndqvlfidqgnrplfedmtdsdcrdnaprtifiismykdsqrrgm
avtisvacaaastlscenkiisfkemnppdnikdtksdiiffqrrvpghdnkmqfesssy
egyflacekerdlfklilkkedelgdrsimftvqned

    Sequence, based on observed residues (ATOM records): (download) 
    >4xfuA (A:)
yfgklesklsvirnlndqvlfidqgnrplfedmtnaprtifiismykdsqrrgmavtisv
acaaastlscenkiisfkemnppdnikdtksdiiffqrrvpghdnkmqfesssyegyfla
cekerdlfklilkkeelgdrsimftvqne

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4xfuB (B:)
yfgklesklsvirnlndqvlfidqgnrplfedmtdsdcrdnaprtifiismykdsqrrgm
avtisvacaaastlscenkiisfkemnppdnikdtksdiiffqrrvpghdnkmqfesssy
egyflacekerdlfklilkkedelgdrsimftvqned

    Sequence, based on observed residues (ATOM records): (download) 
    >4xfuB (B:)
yfgklesklsvirnlndqvlfidqgnrplfedmtdaprtifiismykdsqrrgmavtisv
acaaastlscenkiisfkemnppdnikdtksdiiffqrrvpghdnkmqfesssyegyfla
cekerdlfklilkkedelgdrsimftvqne