PDB entry 4uwd

View 4uwd on RCSB PDB site
Description: HIF prolyl hydroxylase 2 (PHD2/ EGLN1) D315E VARIANT in complex with Mn(II) and N-[(1-chloro-4-hydroxyisoquinolin-3-yl)carbonyl]glycine (IOX3/UN9)
Class: oxidoreductase
Keywords: oxidoreductase, non-heme, iron, 2-oxoglutarate, dioxygenase, hypoxia-inducible factor, hif, hif prolyl hydroxylase domain 2, phd2, egln, oxygenase, hypoxia, DNA-binding, metal-binding, transcription, helix-loop-helix-beta, dsbh, facial triad, asparaginyl/ aspartyl hydroxylase, transcription and epigenetic regulation, signaling, development, cell structure, ankyrin repeat domain, ard, beta-hydroxylation, transcription activator/inhibitor, phosphorylation, s-nitrosylation
Deposited on 2014-08-11, released 2014-08-27
The last revision prior to the SCOPe 2.06 freeze date was dated 2014-10-22, with a file datestamp of 2014-10-17.
Experiment type: XRAY
Resolution: 1.72 Å
R-factor: 0.1507
AEROSPACI score: 0.5 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: Egl nine homolog 1
  Species: Homo sapiens [TaxId:9606]
  Database cross-references and differences (RAF-indexed):
  • Uniprot Q9GZT9
    • engineered mutation (140)
  Domains in SCOPe 2.06: d4uwda_
• Heterogens: MN, UN9, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence, based on SEQRES records: (download)
  

  >4uwdA (A:)
  gshmaspngqtkplpalklaleyivpcmnkhgicvvddflgketgqqigdevralhdtgk
  ftdgqlvsqksdsskdirgdkitwiegkepgcetigllmssmddlirhcngklgsyking
  rtkamvacypgngtgyvrhvenpngdgrcvtciyylnkdwdakvsggilrifpegkaqfa
  diepkfdrllffwsdrrnphevqpayatryaitvwyfdaderarakvkyltgekgvrvel
  nkpsdsvgkdvf
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >4uwdA (A:)
  lpalklaleyivpcmnkhgicvvddflgketgqqigdevralhdtgkftdgqlvsqksds
  skdirgdkitwiegkepgcetigllmssmddlirhcngklgsykingrtkamvacypgng
  tgyvrhvenpngdgrcvtciyylnkdwdakvsggilrifpegkaqfadiepkfdrllffw
  sdrrnphevqpayatryaitvwyfdaderarakvkylgekg