PDB entry 4un0

View 4un0 on RCSB PDB site
Description: Crystal structure of the human CDK12-cyclinK complex
Class: transferase
Keywords: transferase
Deposited on 2014-05-22, released 2014-06-04
The last revision prior to the SCOPe 2.06 freeze date was dated 2015-12-09, with a file datestamp of 2015-12-04.
Experiment type: XRAY
Resolution: 3.15 Å
R-factor: N/A
AEROSPACI score: 0.13 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cyclin-k
    Species: Homo sapiens [TaxId:9606]
    Gene:
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4un0a1, d4un0a2
  • Chain 'B':
    Compound: cyclin-k
    Species: Homo sapiens [TaxId:9606]
    Gene:
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4un0b1, d4un0b2
  • Chain 'C':
    Compound: cyclin-dependent kinase 12
    Species: Homo sapiens [TaxId:9606]
    Gene:
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4un0c_
  • Chain 'D':
    Compound: cyclin-dependent kinase 12
    Species: Homo sapiens [TaxId:9606]
    Gene:
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4un0d_

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4un0A (A:)
smsvtsanldhtkpcwywdkkdlahtpsqlegldpatearyrregarfifdvgtrlglhy
dtlatgiiyfhrfymfhsfkqfpryvtgacclflagkveetpkkckdiiktarsllndvq
fgqfgddpkeevmvlerillqtikfdlqvehpyqfllkyakqlkgdknkiqklvqmawtf
vndslcttlslqwepeiiavavmylagrlckfeiqewtskpmyrrwweqfvqdvpvdvle
dichqildlysqgkqqmph

    Sequence, based on observed residues (ATOM records): (download) 
    >4un0A (A:)
pcwywdkkdlahtpsqlegldpatearyrregarfifdvgtrlglhydtlatgiiyfhrf
ymfhsfkqfpryvtgacclflagkveetpkkckdiiktarsllndvqfgqfgddpkeevm
vlerillqtikfdlqvehpyqfllkyakqlkgdknkiqklvqmawtfvndslcttlslqw
epeiiavavmylagrlckfeiqewtskpmyrrwweqfvqdvpvdvledichqildlysq

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4un0B (B:)
smsvtsanldhtkpcwywdkkdlahtpsqlegldpatearyrregarfifdvgtrlglhy
dtlatgiiyfhrfymfhsfkqfpryvtgacclflagkveetpkkckdiiktarsllndvq
fgqfgddpkeevmvlerillqtikfdlqvehpyqfllkyakqlkgdknkiqklvqmawtf
vndslcttlslqwepeiiavavmylagrlckfeiqewtskpmyrrwweqfvqdvpvdvle
dichqildlysqgkqqmph

    Sequence, based on observed residues (ATOM records): (download) 
    >4un0B (B:)
pcwywdkkdlahtpsqlegldpatearyrregarfifdvgtrlglhydtlatgiiyfhrf
ymfhsfkqfpryvtgacclflagkveetpkkckdiiktarsllndvqfgqfgddpkeevm
vlerillqtikfdlqvehpyqfllkyakqlkgdknkiqklvqmawtfvndslcttlslqw
epeiiavavmylagrlckfeiqewtskprrwweqfvqdvpvdvledichqildlysq

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4un0C (C:)
smtesdwgkrcvdkfdiigiigegtygqvykakdkdtgelvalkkvrldnekegfpitai
reikilrqlihrsvvnmkeivtdkqdaldfkkdkgafylvfeymdhdlmgllesglvhfs
edhiksfmkqlmegleychkknflhrdikcsnillnnsgqikladfglarlynseesrpy
tnkvitlwyrppelllgeerytpaidvwscgcilgelftkkpifqanlelaqlelisrlc
gspcpavwpdviklpyfntmkpkkqyrrrlreefsfipsaaldlldhmltldpskrctae
qtlqsdflkdvelskmappdlphwqd

    Sequence, based on observed residues (ATOM records): (download) 
    >4un0C (C:)
wgkrcvdkfdiigiigegtygqvykakdkdtgelvalkkvrldnekegfpitaireikil
rqlihrsvvnmkeivtdkkdkgafylvfeymdhdlmgllesglvhfsedhiksfmkqlme
gleychkknflhrdikcsnillnnsgqikladfglarlynseesrpytnkvitlwyrppe
lllgeerytpaidvwscgcilgelftkkpifqanlelaqlelisrlcgspcpavwpdvik
lpyfntmkpqyrrrlreefsfipsaaldlldhmltldpskrctaeqtlqsdflkdvelsk
mappdlphw

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4un0D (D:)
smtesdwgkrcvdkfdiigiigegtygqvykakdkdtgelvalkkvrldnekegfpitai
reikilrqlihrsvvnmkeivtdkqdaldfkkdkgafylvfeymdhdlmgllesglvhfs
edhiksfmkqlmegleychkknflhrdikcsnillnnsgqikladfglarlynseesrpy
tnkvitlwyrppelllgeerytpaidvwscgcilgelftkkpifqanlelaqlelisrlc
gspcpavwpdviklpyfntmkpkkqyrrrlreefsfipsaaldlldhmltldpskrctae
qtlqsdflkdvelskmappdlphwqd

    Sequence, based on observed residues (ATOM records): (download) 
    >4un0D (D:)
cvdkfdiigiigegtygqvykakdkdtgelvalkkvrlkegfpitaireikilrqlihrs
vvnmkeivtdafylvfeymdhdlmgllhfsedhiksfmkqlmegleychkknflhrdikc
snillnnsgqikladfglarlynpytnkvitlwyrppelllgeerytpaidvwscgcilg
elftkkpifqanlelaqlelisrlcgspcpavwpdviklpyfntmkpkkqyrrrlreefs
fipsaaldlldhmltldpskrctaeqtlqsdflkdve