PDB entry 4u6v

View 4u6v on RCSB PDB site
Description: Mechanisms of Neutralization of a Human Anti-Alpha Toxin Antibody
Class: immune system
Keywords: alpha toxin, Fab, Staphylococcus aureus, mutagenesis, IMMUNE SYSTEM
Deposited on 2014-07-29, released 2014-09-17
The last revision prior to the SCOPe 2.04 freeze date was dated 2014-09-17, with a file datestamp of 2014-09-12.
Experiment type: XRAY
Resolution: 2.56 Å
R-factor: 0.2
AEROSPACI score: 0.24 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: alpha-hemolysin
    Species: Staphylococcus aureus subsp. aureus TCH60 [TaxId:548473]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d4u6va_
  • Chain 'B':
    Compound: alpha-hemolysin
    Species: Staphylococcus aureus subsp. aureus TCH60 [TaxId:548473]
    Database cross-references and differences (RAF-indexed):
  • Chain 'H':
    Compound: Fab, antigen binding fragment, heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4U6V (0-End)
  • Chain 'K':
    Compound: Fab, antigen binding fragment, heavy chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4U6V (0-End)
  • Chain 'L':
    Compound: Fab, antigen binding fragment, light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4U6V (0-212)
  • Chain 'M':
    Compound: Fab, antigen binding fragment, light chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4U6V (0-212)
    Domains in SCOPe 2.04: d4u6vm1, d4u6vm2
  • Heterogens: SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4u6vA (A:)
adsdiniktgttdigsnttvktgdlvtydkengmhkkvfysfiddknhnkkllvirtkgt
iagqyrvyseeganksglawpsafkvqlqlpdnevaqisdyyprnsidtkeymstltygf
ngnvtgddtgkiggliganvsightlkyvqpdfktilesptdkkvgwkvifnnmvnqnwg
pydrdswnpvygnqlfmktrngsmkaadnfldpnkassllssgfspdfatvitmdrkask
qqtnidviyervrddyqlhwtstnwkgtntkdkwidrsserykidwekeemtn

    Sequence, based on observed residues (ATOM records): (download) 
    >4u6vA (A:)
tdigsnttvktgdlvtydkengmhkkvfysfiddknhnkkllvirtkgtiagqyrvysee
ganksglawpsafkvqlqlpdnevaqisdyyprnsidtkeymstltygfngnvtgganvs
ightlkyvqpdfktilesptdkkvgwkvifnnmvnqnwgpydrdswnpvygnqlfmktrn
gsmkaadnfldpnkassllssgfspdfatvitmdrkaskqqtnidviyervrddyqlhwt
stnwkgtntkdkwidrsserykidwekeemtn

  • Chain 'B':
    No sequence available.

  • Chain 'H':
    No sequence available.

  • Chain 'K':
    No sequence available.

  • Chain 'L':
    No sequence available.

  • Chain 'M':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4u6vM (M:)
diqmtqspstlsasvgdrvtitcrasqsisswlawyqqkpgkapklliykasslesgvps
rfsgsgsgteftltisslqpddfatyyckqyadywtfgqgtkveikrtvaapsvfifpps
deqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstltl
skadyekhkvyacevthqglsspvtksfnrgec