PDB entry 4rql

View 4rql on RCSB PDB site
Description: Crystal structure of a human cytochrome P450 2B6 (Y226H/K262R) in complex with a monoterpene - sabinene
Class: oxidoreductase
Keywords: P450, cytochrome P450 2B6, monooxygenase, membrane protein, CYP2B6, endoplasmic reticulum, heme, iron, metal binding, microsome, OXIDOREDUCTASE
Deposited on 2014-11-03, released 2015-01-28
The last revision prior to the SCOPe 2.08 freeze date was dated 2015-03-11, with a file datestamp of 2015-03-06.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: N/A
AEROSPACI score: 0.29 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cytochrome P450 2B6
    Species: Homo sapiens [TaxId:9606]
    Gene: CYP2B6
    Database cross-references and differences (RAF-indexed):
    • Uniprot P20813 (Start-471)
      • engineered mutation (9)
      • engineered mutation (206)
      • engineered mutation (242)
      • expression tag (472)
    Domains in SCOPe 2.08: d4rqla1, d4rqla2
  • Chain 'B':
    Compound: Cytochrome P450 2B6
    Species: Homo sapiens [TaxId:9606]
    Gene: CYP2B6
    Database cross-references and differences (RAF-indexed):
    • Uniprot P20813 (Start-471)
      • engineered mutation (9)
      • engineered mutation (206)
      • engineered mutation (242)
      • expression tag (472)
    Domains in SCOPe 2.08: d4rqlb1, d4rqlb2
  • Heterogens: HEM, CM5, SNE, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4rqlA (A:)
makktsskgklppgprplpllgnllqmdrrgllksflrfrekygdvftvhlgprpvvmlc
gveairealvdkaeafsgrgkiamvdpffrgygvifangnrwkvlrrfsvttmrdfgmgk
rsveeriqeeaqclieelrkskgalmdptflfqsitaniicsivfgkrfhyqdqeflkml
nlfyqtfslissvfgqlfelfsgflkhfpgahrqvyknlqeinayighsvekhretldps
aprdlidtyllhmekeksnahsefshqnlnlntlslffagtettsttlrygfllmlkyph
vaervyreieqvigphrppelhdrakmpyteaviyeiqrfsdllpmgvphivtqhtsfrg
yiipkdtevflilstalhdphyfekpdafnpdhfldangalkkteafipfslgkriclge
giaraelflffttilqnfsmaspvapedidltpqecgvgkipptyqirflprhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4rqlA (A:)
gklppgprplpllgnllqmdrrgllksflrfrekygdvftvhlgprpvvmlcgveairea
lvdkaeafsgrgkiamvdpffrgygvifangnrwkvlrrfsvttmrdfgmgkrsveeriq
eeaqclieelrkskgalmdptflfqsitaniicsivfgkrfhyqdqeflkmlnlfyqtfs
lissvfgqlfelfsgflkhfpgahrqvyknlqeinayighsvekhretldpsaprdlidt
yllhmekeksnahsefshqnlnlntlslffagtettsttlrygfllmlkyphvaervyre
ieqvigphrppelhdrakmpyteaviyeiqrfsdllpmgvphivtqhtsfrgyiipkdte
vflilstalhdphyfekpdafnpdhfldangalkkteafipfslgkriclgegiaraelf
lffttilqnfsmaspvapedidltpqecgvgkipptyqirflprh

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4rqlB (B:)
makktsskgklppgprplpllgnllqmdrrgllksflrfrekygdvftvhlgprpvvmlc
gveairealvdkaeafsgrgkiamvdpffrgygvifangnrwkvlrrfsvttmrdfgmgk
rsveeriqeeaqclieelrkskgalmdptflfqsitaniicsivfgkrfhyqdqeflkml
nlfyqtfslissvfgqlfelfsgflkhfpgahrqvyknlqeinayighsvekhretldps
aprdlidtyllhmekeksnahsefshqnlnlntlslffagtettsttlrygfllmlkyph
vaervyreieqvigphrppelhdrakmpyteaviyeiqrfsdllpmgvphivtqhtsfrg
yiipkdtevflilstalhdphyfekpdafnpdhfldangalkkteafipfslgkriclge
giaraelflffttilqnfsmaspvapedidltpqecgvgkipptyqirflprhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4rqlB (B:)
gklppgprplpllgnllqmdrrgllksflrfrekygdvftvhlgprpvvmlcgveairea
lvdkaeafsgrgkiamvdpffrgygvifangnrwkvlrrfsvttmrdfgmgkrsveeriq
eeaqclieelrkskgalmdptflfqsitaniicsivfgkrfhyqdqeflkmlnlfyqtfs
lissvfgqlfelfsgflkhfpgahrqvyknlqeinayighsvekhretldpsaprdlidt
yllhmekeksnahsefshqnlnlntlslffagtettsttlrygfllmlkyphvaervyre
ieqvigphrppelhdrakmpyteaviyeiqrfsdllpmgvphivtqhtsfrgyiipkdte
vflilstalhdphyfekpdafnpdhfldangalkkteafipfslgkriclgegiaraelf
lffttilqnfsmaspvapedidltpqecgvgkipptyqirflprh