PDB entry 4riy

View 4riy on RCSB PDB site
Description: Crystal structure of an EGFR/HER3 kinase domain heterodimer containing the cancer-associated HER3-E909G mutation
Class: transferase
Keywords: receptor tyrosine kinase, pseudokinase, kinase, ATP binding, membrane, transferase
Deposited on 2014-10-07, released 2014-12-10
The last revision prior to the SCOPe 2.07 freeze date was dated 2014-12-17, with a file datestamp of 2014-12-12.
Experiment type: XRAY
Resolution: 2.98 Å
R-factor: 0.221
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Receptor tyrosine-protein kinase erbB-3
    Species: Homo sapiens [TaxId:9606]
    Gene: ERBB3, HER3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P21860
      • engineered mutation (233)
    Domains in SCOPe 2.07: d4riya_
  • Chain 'B':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00533
      • engineered mutation (270)
    Domains in SCOPe 2.07: d4riyb_
  • Chain 'C':
    Compound: Receptor tyrosine-protein kinase erbB-3
    Species: Homo sapiens [TaxId:9606]
    Gene: ERBB3, HER3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P21860
      • engineered mutation (233)
    Domains in SCOPe 2.07: d4riyc_
  • Chain 'D':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00533
      • engineered mutation (270)
    Domains in SCOPe 2.07: d4riyd_
  • Heterogens: ANP, MG, ADP

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4riyA (A:)
    gagkvlarifketelrklkvlgsgvfgtvhkgvwipegesikipvcikviedksgrqsfq
    avtdhmlaigsldhahivrllglcpgsslqlvtqylplgslldhvrqhrgalgpqlllnw
    gvqiakgmyyleehgmvhrnlaarnvllkspsqvqvadfgvadllppddkqllyseaktp
    ikwmalesihfgkythqsdvwsygvtvwelmtfgaepyaglrlaevpdllekggrlaqpq
    ictidvymvmvkcwmidenirptfkelaneftrmardpprylvikresgpgiapgpephg
    ltnkkleevelepeldldldleaeed
    

    Sequence, based on observed residues (ATOM records): (download)
    >4riyA (A:)
    vlarifketelrklkvlgsgvfgtvhkgvwipegesikipvcikviedksgrqsfqavtd
    hmlaigsldhahivrllglcpgsslqlvtqylplgslldhvrqhrgalgpqlllnwgvqi
    akgmyyleehgmvhrnlaarnvllkspsqvqvadfgvadllpppikwmalesihfgkyth
    qsdvwsygvtvwelmtfgaepyaglrlaevpdllekggrlaqpqictidvymvmvkcwmi
    denirptfkelaneftrmardpprylvik
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >4riyB (B:)
    gamgllqerelvepltpsgeapnqallrilketefkkikvlgsgafgtvykglwipegek
    vkipvaikelreatspkankeildeayvmasvdnphvcrllgicltstvqlitqlmpfgc
    lldyvrehkdnigsqyllnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfg
    lakllgaeekeyhaeggkvpikwmalesilhriythqsdvwsygvtvwelmtfgskpydg
    ipaseissilekgerlpqppictidvymimrkcwmidadsrpkfreliiefskmardpqr
    ylviqgdermhlpsptdsnayraamdeedmddvvdadeylipqqg
    

    Sequence, based on observed residues (ATOM records): (download)
    >4riyB (B:)
    lvepltpsgeapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikel
    reatspkankeildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkd
    nigsqyllnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeek
    eyhavpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekge
    rlpqppictidvymimrkcwmidadsrpkfreliiefskmardpqrylviqgd
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >4riyC (C:)
    gagkvlarifketelrklkvlgsgvfgtvhkgvwipegesikipvcikviedksgrqsfq
    avtdhmlaigsldhahivrllglcpgsslqlvtqylplgslldhvrqhrgalgpqlllnw
    gvqiakgmyyleehgmvhrnlaarnvllkspsqvqvadfgvadllppddkqllyseaktp
    ikwmalesihfgkythqsdvwsygvtvwelmtfgaepyaglrlaevpdllekggrlaqpq
    ictidvymvmvkcwmidenirptfkelaneftrmardpprylvikresgpgiapgpephg
    ltnkkleevelepeldldldleaeed
    

    Sequence, based on observed residues (ATOM records): (download)
    >4riyC (C:)
    vlarifketelrklkvlgsgvfgtvhkgvwipegesikipvcikviesfqavtdhmlaig
    sldhahivrllglcpgsslqlvtqylplgslldhvrqhrgalgpqlllnwgvqiakgmyy
    leehgmvhrnlaarnvllkspsqvqvadfgvadllppddkqllyseaktpikwmalesih
    fgkythqsdvwsygvtvwelmtfgaepyaglrlaevpdllekggrlaqpqictidvymvm
    vkcwmidenirptfkelaneftrmardpprylvik
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >4riyD (D:)
    gamgllqerelvepltpsgeapnqallrilketefkkikvlgsgafgtvykglwipegek
    vkipvaikelreatspkankeildeayvmasvdnphvcrllgicltstvqlitqlmpfgc
    lldyvrehkdnigsqyllnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfg
    lakllgaeekeyhaeggkvpikwmalesilhriythqsdvwsygvtvwelmtfgskpydg
    ipaseissilekgerlpqppictidvymimrkcwmidadsrpkfreliiefskmardpqr
    ylviqgdermhlpsptdsnayraamdeedmddvvdadeylipqqg
    

    Sequence, based on observed residues (ATOM records): (download)
    >4riyD (D:)
    lvepltpsgeapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikel
    reatspkankeildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkd
    nigsqyllnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeek
    eyhaeggkvpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissil
    ekgerlpqppictidvymimrkcwmidadsrpkfreliiefskmardpqrylviqgd