PDB entry 4riy

View 4riy on RCSB PDB site
Description: Crystal structure of an EGFR/HER3 kinase domain heterodimer containing the cancer-associated HER3-E909G mutation
Class: transferase
Keywords: receptor tyrosine kinase, pseudokinase, kinase, ATP binding, membrane, transferase
Deposited on 2014-10-07, released 2014-12-10
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-12-17, with a file datestamp of 2014-12-12.
Experiment type: XRAY
Resolution: 2.98 Å
R-factor: 0.221
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Receptor tyrosine-protein kinase erbB-3
    Species: Homo sapiens [TaxId:9606]
    Gene: ERBB3, HER3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P21860
      • engineered mutation (233)
    Domains in SCOPe 2.08: d4riya_
  • Chain 'B':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00533
      • engineered mutation (270)
    Domains in SCOPe 2.08: d4riyb_
  • Chain 'C':
    Compound: Receptor tyrosine-protein kinase erbB-3
    Species: Homo sapiens [TaxId:9606]
    Gene: ERBB3, HER3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P21860
      • engineered mutation (233)
    Domains in SCOPe 2.08: d4riyc_
  • Chain 'D':
    Compound: Epidermal growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: EGFR
    Database cross-references and differences (RAF-indexed):
    • Uniprot P00533
      • engineered mutation (270)
    Domains in SCOPe 2.08: d4riyd_
  • Heterogens: ANP, MG, ADP

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4riyA (A:)
gagkvlarifketelrklkvlgsgvfgtvhkgvwipegesikipvcikviedksgrqsfq
avtdhmlaigsldhahivrllglcpgsslqlvtqylplgslldhvrqhrgalgpqlllnw
gvqiakgmyyleehgmvhrnlaarnvllkspsqvqvadfgvadllppddkqllyseaktp
ikwmalesihfgkythqsdvwsygvtvwelmtfgaepyaglrlaevpdllekggrlaqpq
ictidvymvmvkcwmidenirptfkelaneftrmardpprylvikresgpgiapgpephg
ltnkkleevelepeldldldleaeed

    Sequence, based on observed residues (ATOM records): (download) 
    >4riyA (A:)
vlarifketelrklkvlgsgvfgtvhkgvwipegesikipvcikviedksgrqsfqavtd
hmlaigsldhahivrllglcpgsslqlvtqylplgslldhvrqhrgalgpqlllnwgvqi
akgmyyleehgmvhrnlaarnvllkspsqvqvadfgvadllpppikwmalesihfgkyth
qsdvwsygvtvwelmtfgaepyaglrlaevpdllekggrlaqpqictidvymvmvkcwmi
denirptfkelaneftrmardpprylvik

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4riyB (B:)
gamgllqerelvepltpsgeapnqallrilketefkkikvlgsgafgtvykglwipegek
vkipvaikelreatspkankeildeayvmasvdnphvcrllgicltstvqlitqlmpfgc
lldyvrehkdnigsqyllnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfg
lakllgaeekeyhaeggkvpikwmalesilhriythqsdvwsygvtvwelmtfgskpydg
ipaseissilekgerlpqppictidvymimrkcwmidadsrpkfreliiefskmardpqr
ylviqgdermhlpsptdsnayraamdeedmddvvdadeylipqqg

    Sequence, based on observed residues (ATOM records): (download) 
    >4riyB (B:)
lvepltpsgeapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikel
reatspkankeildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkd
nigsqyllnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeek
eyhavpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissilekge
rlpqppictidvymimrkcwmidadsrpkfreliiefskmardpqrylviqgd

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4riyC (C:)
gagkvlarifketelrklkvlgsgvfgtvhkgvwipegesikipvcikviedksgrqsfq
avtdhmlaigsldhahivrllglcpgsslqlvtqylplgslldhvrqhrgalgpqlllnw
gvqiakgmyyleehgmvhrnlaarnvllkspsqvqvadfgvadllppddkqllyseaktp
ikwmalesihfgkythqsdvwsygvtvwelmtfgaepyaglrlaevpdllekggrlaqpq
ictidvymvmvkcwmidenirptfkelaneftrmardpprylvikresgpgiapgpephg
ltnkkleevelepeldldldleaeed

    Sequence, based on observed residues (ATOM records): (download) 
    >4riyC (C:)
vlarifketelrklkvlgsgvfgtvhkgvwipegesikipvcikviesfqavtdhmlaig
sldhahivrllglcpgsslqlvtqylplgslldhvrqhrgalgpqlllnwgvqiakgmyy
leehgmvhrnlaarnvllkspsqvqvadfgvadllppddkqllyseaktpikwmalesih
fgkythqsdvwsygvtvwelmtfgaepyaglrlaevpdllekggrlaqpqictidvymvm
vkcwmidenirptfkelaneftrmardpprylvik

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4riyD (D:)
gamgllqerelvepltpsgeapnqallrilketefkkikvlgsgafgtvykglwipegek
vkipvaikelreatspkankeildeayvmasvdnphvcrllgicltstvqlitqlmpfgc
lldyvrehkdnigsqyllnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfg
lakllgaeekeyhaeggkvpikwmalesilhriythqsdvwsygvtvwelmtfgskpydg
ipaseissilekgerlpqppictidvymimrkcwmidadsrpkfreliiefskmardpqr
ylviqgdermhlpsptdsnayraamdeedmddvvdadeylipqqg

    Sequence, based on observed residues (ATOM records): (download) 
    >4riyD (D:)
lvepltpsgeapnqallrilketefkkikvlgsgafgtvykglwipegekvkipvaikel
reatspkankeildeayvmasvdnphvcrllgicltstvqlitqlmpfgclldyvrehkd
nigsqyllnwcvqiakgmnyledrrlvhrdlaarnvlvktpqhvkitdfglakllgaeek
eyhaeggkvpikwmalesilhriythqsdvwsygvtvwelmtfgskpydgipaseissil
ekgerlpqppictidvymimrkcwmidadsrpkfreliiefskmardpqrylviqgd