Lineage for d4riya_ (4riy A:)

  1. Root: SCOPe 2.07
  2. 2494617Class d: Alpha and beta proteins (a+b) [53931] (388 folds)
  3. 2542179Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2542180Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 2546221Family d.144.1.0: automated matches [191359] (1 protein)
    not a true family
  6. 2546222Protein automated matches [190417] (29 species)
    not a true protein
  7. 2546365Species Human (Homo sapiens) [TaxId:9606] [187294] (1137 PDB entries)
  8. 2547582Domain d4riya_: 4riy A: [261569]
    Other proteins in same PDB: d4riyb_, d4riyd_
    automated match to d3kexa_
    complexed with adp, anp, mg; mutant

Details for d4riya_

PDB Entry: 4riy (more details), 2.98 Å

PDB Description: Crystal structure of an EGFR/HER3 kinase domain heterodimer containing the cancer-associated HER3-E909G mutation
PDB Compounds: (A:) Receptor tyrosine-protein kinase erbB-3

SCOPe Domain Sequences for d4riya_:

Sequence, based on SEQRES records: (download)

>d4riya_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
vlarifketelrklkvlgsgvfgtvhkgvwipegesikipvcikviedksgrqsfqavtd
hmlaigsldhahivrllglcpgsslqlvtqylplgslldhvrqhrgalgpqlllnwgvqi
akgmyyleehgmvhrnlaarnvllkspsqvqvadfgvadllppddkqllyseaktpikwm
alesihfgkythqsdvwsygvtvwelmtfgaepyaglrlaevpdllekggrlaqpqicti
dvymvmvkcwmidenirptfkelaneftrmardpprylvik

Sequence, based on observed residues (ATOM records): (download)

>d4riya_ d.144.1.0 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
vlarifketelrklkvlgsgvfgtvhkgvwipegesikipvcikviedksgrqsfqavtd
hmlaigsldhahivrllglcpgsslqlvtqylplgslldhvrqhrgalgpqlllnwgvqi
akgmyyleehgmvhrnlaarnvllkspsqvqvadfgvadllpppikwmalesihfgkyth
qsdvwsygvtvwelmtfgaepyaglrlaevpdllekggrlaqpqictidvymvmvkcwmi
denirptfkelaneftrmardpprylvik

SCOPe Domain Coordinates for d4riya_:

Click to download the PDB-style file with coordinates for d4riya_.
(The format of our PDB-style files is described here.)

Timeline for d4riya_: