PDB entry 4p3n

View 4p3n on RCSB PDB site
Description: Structural Basis for Full-Spectrum Inhibition of Threonyl-tRNA Synthetase by Borrelidin 1
Class: ligase/ligase inhibitor
Keywords: synthetase, inhibitor, LIGASE-LIGASE INHIBITOR complex
Deposited on 2014-03-09, released 2015-03-11
The last revision prior to the SCOPe 2.08 freeze date was dated 2019-12-25, with a file datestamp of 2019-12-20.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: N/A
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Threonine--tRNA ligase, cytoplasmic
    Species: Homo sapiens [TaxId:9606]
    Gene: TARS
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4p3na1, d4p3na2
  • Chain 'B':
    Compound: Threonine--tRNA ligase, cytoplasmic
    Species: Homo sapiens [TaxId:9606]
    Gene: TARS
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4p3nb1, d4p3nb2
  • Chain 'C':
    Compound: Threonine--tRNA ligase, cytoplasmic
    Species: Homo sapiens [TaxId:9606]
    Gene: TARS
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4p3nc1, d4p3nc2
  • Chain 'D':
    Compound: Threonine--tRNA ligase, cytoplasmic
    Species: Homo sapiens [TaxId:9606]
    Gene: TARS
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4p3nd1, d4p3nd2
  • Heterogens: 2CR, ZN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4p3nA (A:)
mgsshhhhhhssgdhrkigrdqelyffhelspgscfflpkgayiynaliefirseyrkrg
fqevvtpnifnsrlwmtsghwqhysenmfsfevekelfalkpmncpghclmfdhrprswr
elplrladfgvlhrnelsgaltgltrvrrfqqddahifcameqiedeikgcldflrtvys
vfgfsfklnlstrpekflgdievwdqaekqlenslnefgekwelnsgdgafygpkidiqi
kdaigryhqcatiqldfqlpirfnltyvshdgddkkrpvivhrailgsvermiailteny
ggkwpfwlsprqvmvvpvgptcdeyaqkvrqqfhdakfmadidldpgctlnkkirnaqla
qynfilvvgekekisgtvnirtrdnkvhgertisetierlqqlkefrskqaeeef

    Sequence, based on observed residues (ATOM records): (download) 
    >4p3nA (A:)
dhrkigrdqelyffhelspgscfflpkgayiynaliefirseyrkrgfqevvtpnifnsr
lwmtsghwqhysenmfsfevekelfalkpmncpghclmfdhrprswrelplrladfgvlh
rnelsgaltgltrvrrfqqddahifcameqiedeikgcldflrtvysvfgfsfklnlstr
pekflgdievwdqaekqlenslnefgekwelnsgdgafygpkidiqikdaigryhqcati
qldfqlpirfnltyvshdgddkkrpvivhrailgsvermiailtenyggkwpfwlsprqv
mvvpvgptcdeyaqkvrqqfhdakfmadidldpgctlnkkirnaqlaqynfilvvgekek
isgtvnirtrdnkvhgertisetierlqqlkefrskqaeeef

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4p3nB (B:)
mgsshhhhhhssgdhrkigrdqelyffhelspgscfflpkgayiynaliefirseyrkrg
fqevvtpnifnsrlwmtsghwqhysenmfsfevekelfalkpmncpghclmfdhrprswr
elplrladfgvlhrnelsgaltgltrvrrfqqddahifcameqiedeikgcldflrtvys
vfgfsfklnlstrpekflgdievwdqaekqlenslnefgekwelnsgdgafygpkidiqi
kdaigryhqcatiqldfqlpirfnltyvshdgddkkrpvivhrailgsvermiailteny
ggkwpfwlsprqvmvvpvgptcdeyaqkvrqqfhdakfmadidldpgctlnkkirnaqla
qynfilvvgekekisgtvnirtrdnkvhgertisetierlqqlkefrskqaeeef

    Sequence, based on observed residues (ATOM records): (download) 
    >4p3nB (B:)
dhrkigrdqelyffhelspgscfflpkgayiynaliefirseyrkrgfqevvtpnifnsr
lwmtsghwqhysenmfsfevekelfalkpmncpghclmfdhrprswrelplrladfgvlh
rnelsgaltgltrvrrfqqddahifcameqiedeikgcldflrtvysvfgfsfklnlstr
pekflgdievwdqaekqlenslnefgekwelnsgdgafygpkidiqikdaigryhqcati
qldfqlpirfnltyvshdgddkkrpvivhrailgsvermiailtenyggkwpfwlsprqv
mvvpvgptcdeyaqkvrqqfhdakfmadidldpgctlnkkirnaqlaqynfilvvgekek
isgtvnirtrdnkvhgertisetierlqqlkefrskqaeeef

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4p3nC (C:)
mgsshhhhhhssgdhrkigrdqelyffhelspgscfflpkgayiynaliefirseyrkrg
fqevvtpnifnsrlwmtsghwqhysenmfsfevekelfalkpmncpghclmfdhrprswr
elplrladfgvlhrnelsgaltgltrvrrfqqddahifcameqiedeikgcldflrtvys
vfgfsfklnlstrpekflgdievwdqaekqlenslnefgekwelnsgdgafygpkidiqi
kdaigryhqcatiqldfqlpirfnltyvshdgddkkrpvivhrailgsvermiailteny
ggkwpfwlsprqvmvvpvgptcdeyaqkvrqqfhdakfmadidldpgctlnkkirnaqla
qynfilvvgekekisgtvnirtrdnkvhgertisetierlqqlkefrskqaeeef

    Sequence, based on observed residues (ATOM records): (download) 
    >4p3nC (C:)
dhrkigrdqelyffhelspgscfflpkgayiynaliefirseyrkrgfqevvtpnifnsr
lwmtsghwqhysenmfsfevekelfalkpmncpghclmfdhrprswrelplrladfgvlh
rnelsgaltgltrvrrfqqddahifcameqiedeikgcldflrtvysvfgfsfklnlstr
pekflgdievwdqaekqlenslnefgekwelnsgdgafygpkidiqikdaigryhqcati
qldfqlpirfnltyvshdgddkkrpvivhrailgsvermiailtenyggkwpfwlsprqv
mvvpvgptcdeyaqkvrqqfhdakfmadidldpgctlnkkirnaqlaqynfilvvgekek
isgtvnirtrdnkvhgertisetierlqqlkefrskqaeeef

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4p3nD (D:)
mgsshhhhhhssgdhrkigrdqelyffhelspgscfflpkgayiynaliefirseyrkrg
fqevvtpnifnsrlwmtsghwqhysenmfsfevekelfalkpmncpghclmfdhrprswr
elplrladfgvlhrnelsgaltgltrvrrfqqddahifcameqiedeikgcldflrtvys
vfgfsfklnlstrpekflgdievwdqaekqlenslnefgekwelnsgdgafygpkidiqi
kdaigryhqcatiqldfqlpirfnltyvshdgddkkrpvivhrailgsvermiailteny
ggkwpfwlsprqvmvvpvgptcdeyaqkvrqqfhdakfmadidldpgctlnkkirnaqla
qynfilvvgekekisgtvnirtrdnkvhgertisetierlqqlkefrskqaeeef

    Sequence, based on observed residues (ATOM records): (download) 
    >4p3nD (D:)
dhrkigrdqelyffhelspgscfflpkgayiynaliefirseyrkrgfqevvtpnifnsr
lwmtsghwqhysenmfsfevekelfalkpmncpghclmfdhrprswrelplrladfgvlh
rnelsgaltgltrvrrfqqddahifcameqiedeikgcldflrtvysvfgfsfklnlstr
pekflgdievwdqaekqlenslnefgekwelnsgdgafygpkidiqikdaigryhqcati
qldfqlpirfnltyvshdgddkkrpvivhrailgsvermiailtenyggkwpfwlsprqv
mvvpvgptcdeyaqkvrqqfhdakfmadidldpgctlnkkirnaqlaqynfilvvgekek
isgtvnirtrdnkvhgertisetierlqqlkefrskqaeeef